Linear Scale-Up of Ultrafiltration of High Viscosity Process Streams

Daniels, Christopher C.; Perreault, Mark; Gierl, B; Yegneswaran, P; Gayton, Marshal; Serway, David; Lee, Ann; Rozembersky, John; Pujar, Narahari S.

doi:10.1201/9781420016024.ch19

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“…The regenerated cellulose ultrafiltration membranes of molecular weight cut-off (MWCO) 100 kDa (PLCHK) and 300 kDa (PLCMK) were obtained in the Pellicon-2 ™ Mini format (EMD Millipore, Billerica, MA). Membranes were 1000 cm 2 in area and incorporated suspended screens in the retentate channel (V screen), recommended for feed solutions containing suspended solids or having a high viscosity [ 18 ]. The membranes were charge modified following the procedure of Riordan et al [ 19 ] as in our previous work [ 14 , 20 ].…”

Section: Methodsmentioning

confidence: 99%

Milk Protein Concentration Using Negatively Charged Ultrafiltration Membranes

Arunkumar

Etzel

2018

Foods

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In this work, milk protein concentrate (MPC) was made using wide-pore negatively charged ultrafiltration membranes. The charged membranes were used for a six-fold volume concentration of skim milk and subsequent diafiltration to mimic the industrial MPC process. The charged 100 kDa membranes had at least a four-fold higher permeate flux at the same protein recovery as unmodified 30 kDa membranes, which are currently used in the dairy industry to make MPC. By placing a negative charge on the surface of an ultrafiltration membrane, the negatively charged proteins were rejected by electrostatic repulsion and not simply size-based sieving. Mass balance models of concentration and diafiltration were developed and the calculations matched the experimental observations. This is the first study to use wide-pore charged tangential-flow membranes for MPC manufacturing. Additionally, a unique mass balance model was applied, which accurately predicted experimental results.

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