Linear Streaks of the Equator in the Presumed Ocular Histoplasmosis Syndrome

Multifocal Choroiditis and Panuveitis Presenting With Progressive Equatorial Linear Streaks

“…Fountain and Schlaegel found that about 5% of POHS cases have such lesions and termed this feature as the "fourth sign" of POHS. 1 Multifocal choroiditis and panuveitis is one of the most common white dot syndromes. Nozik and Dorsch 4 described two cases of bilateral anterior uveitis in children associated with chorioretinopathy consisting of scattered, polygonal, and "swordlike depigmented lesions" primarily involving the RPE, Bruch membrane, and/or the choriocapillaris.…”

“…1 The etiology of these lesions has been previously disputed, with histoplasmosis and autoinflammatory uveitis implicated.…”

“…Such lesions have been previously described and debated as the "fourth sign" of the presumed ocular histoplasmosis syndrome (POHS). 1,2 The clinical differential of these lesions includes multifocal choroiditis and panuveitis (MCP) and West Nile virus (WNV). With recent advancements in imaging technology, we can understand more about these particular lesions.…”

Ocular histoplasmosis-like syndrome: a report from a nonendemic area

“…Curvilinear streaks of chorioretinal scars have also been described (3) . POHS affects young healthy adults between the second and fifth decades of life with no gender predilection (4)(5) .…”

Simultaneous presentation of multifocal choroiditis and acute zonal occult outer retinopathy in one eye

“…Fountain and Schlaegel1 noted that peripheral curvilinear streaks composed of chorioretinal scars can be a fourth sign of POHS (figure 1). The convexity of these curvilinear streaks is typically orientated towards the optic nerve unlike the pigmented demarcation line in rhegmatogenous retinal detachment that is usually oriented towards the ora serrata.…”