Linear T2 Hyperintensity along the Medial Margin of the Globus Pallidus in Patients with Machado-Joseph Disease and Parkinson Disease, and in Healthy Subjects

Shirai, Wakako; Ito, Shingo; Hattori, Takaaki

doi:10.3174/ajnr.a0705

Cited by 8 publications

(3 citation statements)

References 11 publications

(14 reference statements)

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“…[7] In this regard, it is important to remember that BGPTH may occur as part of the normal ageing process, especially after the age of 60 years, and it is rare in younger people. [8]…”

Section: Discussionmentioning

confidence: 99%

A sound sleep

Goswami¹,

Mondal²,

Basu³

et al. 2012

Indian Journal of Critical Care Medicine

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Benzodiazepine is a commonly encountered agent of poisoning, which is readily diagnosed by a pertinent history of drug ingestion and the clinical scenario. In the absence of a proper drug history, the diagnosis becomes challenging. Proper clinical assessment, urine assays and imaging play a very important role in reaching the diagnosis. We present a case of acute benzodiazepine poisoning without a history of drug intake. The key pointers toward diagnosis were an unarousable state with obstructive apnea. Magnetic resonance imaging (MRI) of the brain revealed peculiar symmetrical isolated globus pallidus T2 hyperintensity. We believe this to be the first report of isolated bilateral basal ganglia T2-weighted hyperintensity in MRI in the setting of acute benzodiazepine poisoning from India.

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“…[7] In this regard, it is important to remember that BGPTH may occur as part of the normal ageing process, especially after the age of 60 years, and it is rare in younger people. [8]…”

Section: Discussionmentioning

confidence: 99%

A sound sleep

Goswami¹,

Mondal²,

Basu³

et al. 2012

Indian Journal of Critical Care Medicine

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“… 1 This finding is not pathognomonic of MJD, although it has been described in subjects with other types of spinocerebellar ataxias and in healthy elderly people. 2 …”

Section: Figurementioning

confidence: 99%

T2-hyperintensity in the internal globus pallidus in Machado-Joseph disease

Meira,

Araruna,

Araujo

et al. 2023

Arq Neuropsiquiatr

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“…There have been several reports showing the usefulness of brain magnetic resonance imaging (MRI), and MJD patients have atrophy of the brain stem 13–20. Atrophy of the pontine tegmentum is important, but no practical method of detecting it has been fully assessed.…”

mentioning

confidence: 99%

Flattened facial colliculus on magnetic resonance imaging in Machado–Joseph disease

et al. 2012

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Atrophy of the pontine tegmentum and facial colliculus is a characteristic pathological feature of Machado-Joseph disease. We assessed whether this finding can be detected by conventional brain magnetic resonance imaging. A total of 17 patients with genetically confirmed Machado-Joseph disease, 15 disease controls (spinocerebellar ataxia type 6 and dentatorubral-pallidoluysian atrophy), and 17 normal subjects were examined using a 1.5-Tesla magnetic resonance imaging scanner. The widths of the facial colliculus, pontine tegmentum, and pontine base and the area of the fourth ventricle were measured on axial T2-weighted imaging. Pathological examination was performed in 9 Machado-Joseph disease patients. In addition, visual inspection of the facial colliculus was evaluated by receiver operating characteristic analysis. The width of the facial colliculus was significantly smaller in Machado-Joseph disease patients (0.37 ± 0.16 mm; mean ± standard deviation) than in normal subjects (0.73 ± 0.30 mm; P < .01), whereas the width of the pontine tegmentum was smaller in both Machado-Joseph disease (4.85 ± 0.58 mm) and dentatorubral-pallidoluysian atrophy (4.72 ± 0.59) patients than in normal subjects (6.35 ± 0.74 mm; P < .01). Visual evaluation of the facial colliculus showed sufficient area under the receiver operating characteristic curves to differentiate Machado-Joseph disease from dentatorubral-pallidoluysian atrophy (0.78) and spinocerebellar ataxia type 6 (0.87). Pathological evaluation showed significant atrophy of the facial colliculus in all Machado-Joseph disease patients. Atrophy of the facial colliculus is a feasible magnetic resonance imaging finding for diagnosing Machado-Joseph disease, and it is easily found as a flattening of the fourth ventricular floor.

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Linear T2 Hyperintensity along the Medial Margin of the Globus Pallidus in Patients with Machado-Joseph Disease and Parkinson Disease, and in Healthy Subjects

Cited by 8 publications

References 11 publications

A sound sleep

A sound sleep

T2-hyperintensity in the internal globus pallidus in Machado-Joseph disease

Flattened facial colliculus on magnetic resonance imaging in Machado–Joseph disease

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