Linear Type Azo-Containing Polyurethanes for Colon-Specific Drug Delivery

Mahkam, Mehrdad; Assadi, M. G.; Zahedifar, R.; Ramesh, M.; Davaran, Soodabeh

doi:10.1177/0883911504041602

Cited by 22 publications

(16 citation statements)

References 24 publications

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“…It is expected that at tumor pH, the doxorubicin-loaded nanoparticles made of Fe 3 O 4 -PLGA-PEG can show enhanced cytotoxicity compared with that at normal pH. [70][71][72][73][74] In this paper, higher and faster doxorubicin release was observed for Fe 3 O 4 -PLGA-PEG 4000 nanoparticles than for Fe 3 O 4 -PLGA-PEG 3000 and Fe 3 O 4 -PLGA-PEG 2000 at 12 hours. This difference could be to the presence of PEG 4000 in the PLGA chains.…”

Section: Discussionmentioning

confidence: 88%

Preparation and in vitro evaluation of doxorubicin-loaded Fe3O4 magnetic nanoparticles modified with biocompatible copolymers

Akbarzadeh

Mikaeili²,

Zarghami³

et al. 2012

IJN

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Background Superparamagnetic iron oxide nanoparticles are attractive materials that have been widely used in medicine for drug delivery, diagnostic imaging, and therapeutic applications. In our study, superparamagnetic iron oxide nanoparticles and the anticancer drug, doxorubicin hydrochloride, were encapsulated into poly (D, L-lactic-co-glycolic acid) poly (ethylene glycol) (PLGA-PEG) nanoparticles for local treatment. The magnetic properties conferred by superparamagnetic iron oxide nanoparticles could help to maintain the nanoparticles in the joint with an external magnet. Methods A series of PLGA:PEG triblock copolymers were synthesized by ring-opening polymerization of D, L-lactide and glycolide with different molecular weights of polyethylene glycol (PEG 2000 , PEG 3000 , and PEG 4000 ) as an initiator. The bulk properties of these copolymers were characterized using 1 H nuclear magnetic resonance spectroscopy, gel permeation chromatography, Fourier transform infrared spectroscopy, and differential scanning calorimetry. In addition, the resulting particles were characterized by x-ray powder diffraction, scanning electron microscopy, and vibrating sample magnetometry. Results The doxorubicin encapsulation amount was reduced for PLGA:PEG 2000 and PLGA:PEG 3000 triblock copolymers, but increased to a great extent for PLGA:PEG 4000 triblock copolymer. This is due to the increased water uptake capacity of the blended triblock copolymer, which encapsulated more doxorubicin molecules into a swollen copolymer matrix. The drug encapsulation efficiency achieved for Fe 3 O 4 magnetic nanoparticles modified with PLGA:PEG 2000 , PLGA:PEG 3000 , and PLGA:PEG 4000 copolymers was 69.5%, 73%, and 78%, respectively, and the release kinetics were controlled. The in vitro cytotoxicity test showed that the Fe 3 O 4 -PLGA:PEG 4000 magnetic nanoparticles had no cytotoxicity and were biocompatible. Conclusion There is potential for use of these nanoparticles for biomedical application. Future work includes in vivo investigation of the targeting capability and effectiveness of these nanoparticles in the treatment of lung cancer.

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Section: Discussionmentioning

confidence: 88%

Preparation and in vitro evaluation of doxorubicin-loaded Fe3O4 magnetic nanoparticles modified with biocompatible copolymers

Akbarzadeh

Mikaeili²,

Zarghami³

et al. 2012

IJN

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“…Only a handful of studies have reported the successful use of polyurethanes in drug delivery applications, and their favorable results support further examination of this approach [28][29][30][31][32][33]. Our peptide-based urethane possesses the versatility of commercial polyurethane systems, but lacks the toxicity associated with commercial urethane degradation products.…”

Section: Introductionmentioning

confidence: 71%

LDI–glycerol polyurethane implants exhibit controlled release of DB-67 and anti-tumor activity in vitro against malignant gliomas

et al. 2008

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“…The colon is known to be a reductive medium in which azo groups can be cleaved with formation of the corresponding amines. The metabolic reduction of azo compounds is considered as an important detoxification route [22,24]. Various prodrugs (sulfasalazine, ipsalazine, balsalazine and olsalazine) have been developed that are aimed to deliver 5-amino salicylic acid (5-ASA) for localized chemotherapy of IBD [25].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of new cross-linked terpolymer systems containing silyl group

et al. 2006

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A series of acrylic terpolymers containing silyl pendant groups was prepared by free radical cross-linking copolymerization. Me 3 Si, Et 3 Si and t-BuMe 2 Si together with cubane-1, 4-dicarboxylic acid (CDA) were covalently linked with 2-hydroxyethyl methacrylate (HEMA). The silyl-linked HEMA are abbreviated as TMSiEMA, TESiEMA and TBSiEMA respectively. Cubane-1, 4-dicarboxylic acid (CDA) linked to two HEMA group is the cross-linking agent (CA). Free radical cross-linking terpolymerization of the methyl methacrylate (MMA) and methacrylic acid (MAA) with two different molar ratios of organosilyl monomers and CA was carried out at 60-70 • C. The compositions of the cross-linked three-dimensional polymers were determined by FT-IR spectroscopy. The glass transition temperature (Tg) of the network polymers was determined calorimetrically. The Tg of network terpolymers increases with increasing of cross-linking degree. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). The gels swelled more in SIF than in SGF. The swelling behaviour of the copolymers was dependent on the content of MAA groups and caused a decrease in gel swelling in pH 1 or an increase in gel swelling in pH 7.4. Based on the great difference in swelling ratio at pH 1 and 7.4 for P-1, P-6 and P-10 appear to be good candidates for colon-specific drug delivery.

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Linear Type Azo-Containing Polyurethanes for Colon-Specific Drug Delivery

Cited by 22 publications

References 24 publications

Preparation and in vitro evaluation of doxorubicin-loaded Fe3O4 magnetic nanoparticles modified with biocompatible copolymers

Preparation and in vitro evaluation of doxorubicin-loaded Fe3O4 magnetic nanoparticles modified with biocompatible copolymers

LDI–glycerol polyurethane implants exhibit controlled release of DB-67 and anti-tumor activity in vitro against malignant gliomas

Synthesis and characterization of new cross-linked terpolymer systems containing silyl group

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