Linezolid-associated optic neuropathy in a patient with ocular sarcoidosis

Kiuchi, Katsuji; Miyashiro, Miki; Kitagawa, Chiemi; Wada, Shinpei

doi:10.1007/s10384-009-0678-3

Cited by 10 publications

(3 citation statements)

References 17 publications

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“…Eighteen patients across twelve case reports were reviewed and data was collected on linezolid dose and length of treatment as well as time to visual recovery. 1 , 2 , 4 , 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 Recovery was typically described in case reports as an improvement in visual function to an acceptable level, usually assessed by visual acuity, visual fields, color vision or improvement in OCT-RNFL edema. It was not uncommon to have evidence of permanent damage, despite subjective return of visual function.…”

Section: Discussionmentioning

confidence: 99%

Linezolid toxic optic neuropathy: A case report and review of visual prognosis

Toolan,

Fondriest,

Keenan

et al. 2023

American Journal of Ophthalmology Case Reports

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Section: Discussionmentioning

confidence: 99%

Linezolid toxic optic neuropathy: A case report and review of visual prognosis

Toolan,

Fondriest,

Keenan

et al. 2023

American Journal of Ophthalmology Case Reports

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“…There have been many reports describing the use of steroid pulse therapy for sarcoidosis, including cardiac sarcoidosis [12,13], neurosarcoidosis [14], and pulmonary sarcoidosis [15,16]. With respect to ocular sarcoidosis, a few previous reports described the use of steroid pulse therapy for panuveitis [17] or optic neuropathy [18], yet to the best of our knowledge, there are no previously published reports on choroidal granuloma. However, Knickelbein et al [19] reported a refractory patient with a large choroidal granuloma, panuveitis, and optic disc edema being treated with high-dose intravenous steroid therapy.…”

Section: Discussionmentioning

confidence: 99%

A Case of Large Sarcoid Choroidal Granuloma Treated with Steroid Pulse Therapy

Kobayashi¹,

Takai²,

Sato³

et al. 2020

Case Rep Ophthalmol

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Purpose: To report a case of large sarcoid choroidal granuloma that was successfully treated with steroid pulse therapy. Case Report: A 38-year-old man presented with the primary complaint of decreased visual acuity (VA) in his left eye. Upon examination, a large white protruding lesion of 10 × 8 papilla diameter in size was observed in the macular region, and slightly temporal to it, in the patient's left eye. Whole-body contrast-enhanced computed tomography performed for differential diagnosis detected numerous enlarged lymph nodes throughout the body, including the bilateral hilar regions. Sarcoidosis was diagnosed by biopsy of the right cervical lymph nodes showing noncaseating epithelioid cell granuloma. The fundus lesion was found to be a choroidal granuloma caused by sarcoidosis, and steroid pulse therapy was started. The granuloma was considerably decreased, and the VA in the left eye improved to 0.7 after 2 months. Conclusion: Steroid pulse therapy was found to be effective as an initial treatment for a large sarcoid choroidal granuloma.

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“…Data from [5,9–11,15–23,32,34,39 ▪ ,40 ▪ ,41–57,58 ▪ ,59–66]. MRSA, methicillin-resistant staphylococcus aureus; TB, tuberculosis.…”

Section: Characteristics Of Linezolid-associated Optic Neuropathymentioning

confidence: 99%

Linezolid optic neuropathy

Miller,

Cao,

McClelland

et al. 2023

Current Opinion in Ophthalmology

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Purpose of review In this article, we reviewed 67 reported cases of linezolid optic neuropathy and describe the common characteristics and expectations for recovery with an emphasis on recent findings in the literature. Recent findings Linezolid classically causes a reversible, duration-dependent optic neuropathy. However, in our review, we found only 66.7% of patients recovered complete visual function. Vision loss most commonly affected visual acuity followed by visual field and color vision. We also found patients taking higher doses of linezolid experienced full recovery less often, suggesting a dose-dependent component of linezolid optic neuropathy. Linezolid use has increased in frequency and duration, especially in the treatment of drug-resistant tuberculosis, and data indicate that these patients experience lower rates of complete vision recovery compared with patients taking linezolid for other indications. Summary Linezolid is an effective medication for treating drug-resistant infections; however, it may result in optic neuropathy. It is reasonable for patients on linezolid to undergo screening examinations, especially those on higher doses or for prolonged duration of therapy.

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Linezolid-associated optic neuropathy in a patient with ocular sarcoidosis

Abstract: Our findings demonstrate that it is important for ophthalmologists as well as physicians and orthopedists to consider the possibility of optic neuropathy caused by long-term use of linezolid.

Cited by 10 publications

References 17 publications

Linezolid toxic optic neuropathy: A case report and review of visual prognosis

Linezolid toxic optic neuropathy: A case report and review of visual prognosis

A Case of Large Sarcoid Choroidal Granuloma Treated with Steroid Pulse Therapy

Linezolid optic neuropathy

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