Linezolid-Associated Posterior Reversible Leuco-encephalopathy Syndrome in a Patient with Disseminated Tuberculosis

Abstract

Neurological side-effects of linezolid manifesting as a posterior reversible leuco-encephalopathy syndrome (PRES) is rare. Early identification of this offending drug might reverse this catastrophic event. We report a 45-year-old female, who was diagnosed as a case of disseminated tuberculosis and was treated with antitubercular drugs (ATT), but later developed ATT-induced hepatitis. She was then put on modified ATT (moxifloxacin, terizidone, and linezolid). In the next two days she developed an altered sensorium. Brain imaging was suggestive of PRES. Linezolid was withdrawn, following which she showed an excellent clinical and radiological recovery.

Posterior reversible encephalopathy syndrome associated with antibiotic therapy: a case report and systematic review

“…After duplicate removal, 187 articles were screened. Title and abstract screening led to the selection of 24 articles for full read, which brought us to a final number of 11 articles fulfilling the inclusion criteria and reporting one case each (Supplementary Table 1) [10][11][12][16][17][18][19][20][21][22][23]. Full data on literature case reports (n = 11) and on our case are summarized in Table 1 and detailed in Supplementary Table 1.…”