Linezolid@MOF-74 as a host–guest system with antimicrobial activity

Abstract

Linezolid (LNZ) is a new-generation synthetic molecule for the antibacterial treatment of severe infections, particularly in infective cases where the bacterial resistance to first-choice drugs is caused by gram-positive pathogens....

Copper(ii)-MOFs for bio-applications

“…Also in recent years, the combination of antibacterial agents or drugs housed in copper-based MOFs have been reported as drug delivery systems due to their favorable biodegradation characteristics in the presence of biological fluids. 112,113 The objective of this combination is to generate multiple mechanisms of antimicrobial action. 95 In 2022, Ramos et al 112 proposed a MOF-74(Cu) system with housed linezolid, and the system effect reported a statistically significant decrease in the minimum inhibitory concentration (MIC) reported for this drug, for which only 0.112 mg of linezolid was required for total inhibition of S. aureus.…”

“…112,113 The objective of this combination is to generate multiple mechanisms of antimicrobial action. 95 In 2022, Ramos et al 112 proposed a MOF-74(Cu) system with housed linezolid, and the system effect reported a statistically significant decrease in the minimum inhibitory concentration (MIC) reported for this drug, for which only 0.112 mg of linezolid was required for total inhibition of S. aureus. In addition, it was reported that MOF-74(Cu) as a study control also causes an inhibition effect on the growth of this bacterial strain; however, Liu in the same year, proposed this same MOF-74 but bimetallic (Mg-Cu), which shows excellent results of the evaluated antibacterial activity.…”

Copper release by MOF-74(Cu): a novel pharmacological alternative to diseases with deficiency of a vital oligoelement

“…29,30 Such apparent disadvantage has been recently explored in potential clinical applications, since the degradation of MOF-74(Mg), under physiological conditions, gradually released Mg(II) metal centers. 31,32 MOF-74 (DOT) ligand was also reported as a non-toxic compound. 33 This work inspired us to investigate the gradual decomposition of MOF-74(Cu) under a physiological environment.…”