Linezolid resistant Staphylococcus aureus

Gandham, Pavani

doi:10.5455/2320-6012.ijrms20141103

Cited by 3 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the contrary, in the third world countries, reported resistance rates to linezolid have been steadily rising up (Meka and Gold, 2004). In India linezolid resistance ranged between 2-20% % (Gandham, 2014), and in Pakistan it ranged 35 and 48.1% (Azhar, et al, 2017;Wali et al, 2022).…”

Section: Discussionmentioning

confidence: 96%

Antibiotic resistance and β-lactamase production and biofilm formation by MRSA Isolated from Dakahlia Governorate, Egypt

Elsawy,

Shohayeb,

El-Banna

et al. 2023

Delta University Scientific Journal

View full text Add to dashboard Cite

Methicillin-resistant Staphylococcus aureus (MRSA) causes a wide range of infections in humans. These infections include pneumonia, abscesses, osteomyelitis, endocarditis, phlebitis, mastitis, and meningitis. This study aimed to investigate MRSA prevalence among patients, outpatients, and health care workers (HCWs) at tertiary university hospitals in Mansoura, Dakahlia. The strains were collected from different sources (puss, blood, eye, urine, HCWs) and PCR was used to detect mecA. The isolates were investigated for their susceptibility to different antibiotic classes and their ability to produce β-lactamases and biofilms. Out of the 200 S. aureus strains, 103 (51.5%) were MRSA. The prevalence of MRSA among inpatients, outpatients, and HCWs was 43.5%, 46.0%, and 61.7%, respectively. MRSA isolates were tested for their susceptibility to 15 antibiotics. More than 50% of the MRSA isolates were resistant to eight antibiotics. Less than 10% of the isolates were resistant to amikacin, ciprofloxacin and lomefloxacin. Alarming resistance levels for vancomycin (23.30%) and linezolid (56.31%) were observed. MRSA strains were multidrug-resistant (MDR) and were resistant to 4-13 antibiotic classes. All MRSA strains were biofilm producers. The strong, moderate and weak biofilm producers were 23.30%, 49.51% and 27.18%, respectively. The percentages of β-lactamase production by inpatients, outpatients, and HCWs were 90%, 95.7%, and 96%, respectively. We may conclude that MRSA isolates are prevalent in outpatients, inpatients, and HCWs in university tertiary hospitals at Mansoura. All MRSA were MDR-resistant and biofilms and most of them were β-lactamase producers. Therefore, infection control procedures must be urgently implemented.

show abstract

Section: Discussionmentioning

confidence: 96%

Antibiotic resistance and β-lactamase production and biofilm formation by MRSA Isolated from Dakahlia Governorate, Egypt

Elsawy,

Shohayeb,

El-Banna

et al. 2023

Delta University Scientific Journal

View full text Add to dashboard Cite

show abstract

“…[8][9] In view of rising prevalence of MRSA and Methicillin resistant coagulase negative Staphylococcus, FDA approved Linezolid as the first antibiotic for use from the oxazolidinone class which acts by inhibition of protein synthesis. 10 Currently, emergence of linezolid resistant Staphylococcus species has been reported worldwide and is a cause of major concern. 11 The main mechanism of resistance is via the mutations in the V domain of the 23S rRNA.…”

Section: Introductionmentioning

confidence: 99%

Emerging Antimicrobial Resistance in Staphylococcus and Spectrum of Oral Oxazolidinone Linezolid in Multidrug Resistant Staphylococcus in a Tertiary Care Hospital

Chopra¹,

Sidhu²,

Oberoi³

et al. 2019

IJCMR

View full text Add to dashboard Cite

Introduction: Staphylococcus species is an asymptomatic colonizer which has exhibited increasing resistance to various antimicrobial agents in the recent times. Although, the organism was naturally susceptible to all the antimicrobial agents, it has acquired multi drug resistance via various mechanisms. In view of rising prevalence antimicrobial resistance, this study was undertaken to study the prevalence of methicillin resistance and the emergence of linezolid resistance amongst the Staphylococcal isolates obtained from various clinical samples in a tertiary care hospital. Material and Methods: This study was conducted from July 2017 to December 2018 in a tertiary care hospital. Clinical specimens were processed, and Staphylococcal isolates were identified using standard microbiological techniques. Antimicrobial resistance pattern of all the Staphylococcal isolates was determined and interpreted as per the latest CLSI guidelines. Results: A total of 989 Staphylococcal isolates were obtained amongst which 498 (49.44%) were found to be methicillin resistant. Highest antimicrobial resistance was observed to beta lactam antibiotics followed by azithromycin and fluoroquinolones. 26 (2.628%) strains of Staphylococcal species were found to be resistant to linezolid while they retained sensitivity to Vancomycin. Conclusion: The emergence of drug resistance in various microorganisms has been a cause of global concern. Rising trend of resistance has been observed to methicillin and linezolid especially in indoor patients of the Intensive care units. This study highlights the high prevalence of Methicillin resistance in both Staphylococcus aureus and Coagulase negative Staphylococcus species in a tertiary care hospital in Amritsar, India. Although, linezolid resistance is emerging at a slow pace, adequate measures must be undertaken to preserve the therapeutic armoury.

show abstract

Detection of high levels of resistance to linezolid and vancomycin in Staphylococcus aureus

Azhar

Rasool

Haque

et al. 2017

Journal of Medical Microbiology

View full text Add to dashboard Cite

Both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) are rapidly overcoming the current array of drugs. One hundred and fifty isolates from a hospital were studied for resistance towards linezolid and vancomycin. Fifty-four (36.0 %) isolates were MRSA. Both MRSA and MSSA showed high resistance towards linezolid when using the disc diffusion method, with the figures being 48.1 and 29.2 %, respectively. The figures for the E-test were 46.3 and 27.0 %, respectively. The vancomycin resistance was remarkable in MRSA (14.8 %), but relatively low in MSSA (3.1 %). The E-test results were 13.0 and 4.16 %, respectively. The cfr gene was detected in 78 % of linezolid-resistant isolates and the vanA operon was detected in 74 % of vancomycin-resistant isolates. This level of resistance against linezolid and vancomycin is unprecedented. These results are alarming and highlight the threat of non-treatable S. aureus strains.

show abstract

Linezolid resistant Staphylococcus aureus

Cited by 3 publications

References 20 publications

Antibiotic resistance and β-lactamase production and biofilm formation by MRSA Isolated from Dakahlia Governorate, Egypt

Antibiotic resistance and β-lactamase production and biofilm formation by MRSA Isolated from Dakahlia Governorate, Egypt

Emerging Antimicrobial Resistance in Staphylococcus and Spectrum of Oral Oxazolidinone Linezolid in Multidrug Resistant Staphylococcus in a Tertiary Care Hospital

Detection of high levels of resistance to linezolid and vancomycin in Staphylococcus aureus

Contact Info

Product

Resources

About