Linfoma intravascular pulmonar detectado mediante FDG PET-TC a propósito de un caso

Kohan, Andrés; Paganini, Lisandro; Biedak, P.; Arma, J.I.; Dalurzo, Mercedes; Garcia-Monaco, Ricardo

doi:10.1016/j.remn.2012.11.002

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…PET-CT has been used for making the initial diagnosis, staging, and assessment of effectiveness of treatments for IVLBCL because these patients usually show high uptake of 18-FDG in involved organs [3,17,18]. A few case reports have found PET-CT helpful in making a diagnosis of IVLBCL by identifying appropriate target sites for lung biopsy when other imaging modalities have failed to detect any abnormalities [3,18]. When PET-CT showed lesions in the peripheral parts of both lower lung fields after 2 random TBLBs had failed to achieve a diagnosis, we decided to obtain a lung biopsy with support of VATS, and this finally confirmed the suspected diagnosis of IVLBCL.…”

Section: Discussionmentioning

confidence: 99%

Intravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies

et al. 2019

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Patient: Female, 75 Final Diagnosis: Intravascular lerge B-cell lymphoma Symptoms: Dyspnea Medication: — Clinical Procedure: — Specialty: Hematology Objective: Rare disease Background: Intravascular large B-cell lymphoma (IVLBCL) is characteristically diagnosed by histological examination of biopsies of bone marrow or randomly harvested skin specimens in the absence of any diagnostic abnormalities on imaging studies, including computed tomography (CT). In particular, diagnosis of IVLBCL with pulmonary manifestations is challenging, because even in patients with severe respiratory failure, there are rarely abnormalities on standard imaging studies. Case Report: A 75-year-old female presented with fatigue, weight loss, and high fever with chills for 3 months. Blood examinations on her initial visit to her primary physician showed high concentrations of C-reactive protein, lactate dehydrogenase, and soluble interleukin-2 receptor. There were no abnormalities on imaging studies. She was subsequently admitted to our hospital because of development of dyspnea over time (4 months after symptom onset). Although she was suspected of having IVLBCL, repeated biopsies from bone marrow, skin, liver, and lung did not result in a diagnosis. Finally, a lung biopsy obtained by video-associated thoracic surgery (VATS) from the right lung base, where fluorine-18 fluorodeoxyglucose positron emission tomography had shown high uptake, resulted in a definite diagnosis of IVLBCL. Conclusions: Highly invasive procedures such as thoracoscopic lung resection may be required to diagnose IVLBCL with pulmonary manifestations which can cause severe respiratory failure in the absence of any abnormalities on standard imaging studies.

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Section: Discussionmentioning

confidence: 99%

Intravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies

et al. 2019

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“…Furthermore, there were 13 previous case reports of pulmonary IVLBCL with FDG-PET/CT ( Table 2 ) ( 10 - 12 , 14 , 29 , 37 , 39 , 43 , 50 ). These reports suggested that 18 F-FDG PET-CT scanning may facilitate suspicion of IVLBCL with pulmonary involvement, even in the absence of radiological findings ( 11 , 12 , 14 , 42 ).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Intravascular Large B-cell Lymphoma (IVLBCL) Disguised as an Asthma Exacerbation in a Patient with Asthma

et al. 2017

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A 62-year-old man with asthma presented with a 1-month history of wheezing and exertional dyspnea. Although the wheezing symptoms disappeared after systemic corticosteroid therapy, the exertional dyspnea and hypoxemia did not improve. A diagnosis of intravascular large B-cell lymphoma (IVLBCL) with pulmonary involvement was suspected because of the increased serum lactic dehydrogenase (LDH) and soluble interleukin-2 receptor (sIL-2R) level, increased alveolar-arterial oxygen difference (AaDO2), decreased pulmonary diffusing capacity for carbon monoxide (DLCO) and scintigraphic, computed tomography (CT) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT findings. The patient was diagnosed as having IVLBCL with pulmonary involvement based on a pathological analysis of a random skin biopsy and a transbronchial lung biopsy. IVLBCL should be considered in patients with symptoms of asthma that are refractory to corticosteroid treatment.

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Analysis of clinicopathological features and prognostic factors of non‑Hodgkin's intravascular large B‑cell lymphoma

Liu

Zhou

et al. 2020

Oncol Lett

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Non-Hodgkin's intravascular large B-cell lymphoma is a highly invasive extranodal lymphoma. The proliferating tumor cells invade the small vessels and capillaries of different organs. The clinical symptoms are atypical, there is lack of specificity, and the molecular and biological behaviors are not clear, thus, the present study aimed to improve the current understanding of non-Hodgkin's intravascular large B-cell lymphoma (IVL) and provide an accurate basis for clinical treatment and prognosis, by retrospectively analyzing and summarizing the clinicopathological features, immunohistochemical findings and molecular characteristics of 17 patients with IVL. The Kaplan-Meier method and log rank test were implemented to determine survival outcomes. Fisher's exact test was used to determine the association between clinicopathological features and the expression levels of Ki-67, c-Myc, B-cell lymphoma 6 (Bcl-6) and B-cell lymphoma 2 (Bcl-2), while multivariate Cox regression analysis was performed to identify the independent risk factors that affect the survival rates of patients with IVL. P<0.05 was considered to indicate a statistically significant difference. Among the 17 patients with IVL, 13 cases (76.47%) occurred in the adrenal gland and four cases (23.53%) occurred on the skin demonstrated positive IgH gene rearrangement. FISH analysis indicated that cleavage of the c-Myc gene was closely associated with sex, hypertension status and tumor size, while cleavage of the Bcl-6 gene was closely associated with tumor size parameters. Overall, the results suggest that the Ki-67 proliferation index is an independent risk factor for the prognosis (survival time) of patients with IVL.

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Linfoma intravascular pulmonar detectado mediante FDG PET-TC a propósito de un caso

Cited by 3 publications

References 9 publications

Intravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies

Intravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies

Pulmonary Intravascular Large B-cell Lymphoma (IVLBCL) Disguised as an Asthma Exacerbation in a Patient with Asthma

Analysis of clinicopathological features and prognostic factors of non‑Hodgkin's intravascular large B‑cell lymphoma

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