LINGO-1 shRNA Loaded by Pluronic F-127 Promotes Functional Recovery After Ventral Root Avulsion

Localised delivery of quercetin by thermo-sensitive PLGA-PEG-PLGA hydrogels for the treatment of brachial plexus avulsion

“…In addition, the data from the blank PLGA-PEG-PLGA hydrogel group showed improvement compared with the control group, but not in a statistically significant way. In our previous BPA experiment, the hydrogel could fill the tissue gap and reduce scar tissues at the junction of spinal cord and peripheral nerves, providing a better channel for axonal growth, indicating that the hydrogel has a certain auxiliary effect in the treatment of BPA [11,45]. Although our results show the promising potential of gel and quercetin application in brachial plexus avulsion therapy, the molecular mechanisms governing quercetin's regulation of functional recovery after BPA have not been fully investigated.…”

PLGA-PEG-PLGA hydrogel with NEP1-40 promotes the functional recovery of brachial plexus root avulsion in adult rats

“…BPA can (i) cause nerve tissue defects, lead to an irregular cavity at the junction area between the spinal cord and the brachial plexus, (ii) subsequently inducing the excessive build-up of scar tissue, and, (iii) finally, impact the penetration of axons ( Carlstedt, 2008 ; Meng et al, 2019 , 2020 ). Therefore, the use of appropriate filling materials with a drug load may be employed to promote nerve regeneration ( Baazil et al, 2015 ; Ding et al, 2019 ). Poly (D, L-lactide-co-glycolide)-poly (ethylene glycol)-poly (D, L-lactide-co-glycolide) (PLGA-PEG-PLGA) is a temperature-sensitive hydrogel that has a wide range of applications in drug delivery owing to its good biocompatibility and safety.…”

“…Poly (D, L-lactide-co-glycolide)-poly (ethylene glycol)-poly (D, L-lactide-co-glycolide) (PLGA-PEG-PLGA) is a temperature-sensitive hydrogel that has a wide range of applications in drug delivery owing to its good biocompatibility and safety. The fluidity and gel-forming properties of PLGA-PEG-PLGA allow it to effectively fill in tissue defects and sustain the delivery of drugs to the site of injury ( Ding et al, 2019 ; Zhang et al, 2014 ). Further, studies have reported that combinations of PLGA-PEG-PLGA hydrogel with drugs can be more efficacious than drugs alone ( Ding et al, 2019 ; Huang et al, 2020 ).…”

“…The fluidity and gel-forming properties of PLGA-PEG-PLGA allow it to effectively fill in tissue defects and sustain the delivery of drugs to the site of injury ( Ding et al, 2019 ; Zhang et al, 2014 ). Further, studies have reported that combinations of PLGA-PEG-PLGA hydrogel with drugs can be more efficacious than drugs alone ( Ding et al, 2019 ; Huang et al, 2020 ). Because treatment with drugs alone, if it is intravenous injection, after the metabolism of the various organs of the body, the actual dose of the drug reaching the injured site is very small, and it cannot even meet the needs of the injured site for treatment.…”

Peer Review #1 of "PLGA-PEG-PLGA hydrogel with NEP1-40 promotes the functional recovery of brachial plexus root avulsion in adult rats (v0.1)"

“…BPA can (i) cause nerve tissue defects, lead to an irregular cavity at the junction area between the spinal cord and the brachial plexus, (ii) subsequently inducing the excessive buildup of scar tissue, and, (iii) finally, impact the penetration of axons (Carlstedt 2008;Meng et al 2019;Meng et al 2020). Therefore, the use of appropriate filling materials with a drug load may be employed to promote nerve regeneration (Baazil et al 2015;Ding et al 2019). Poly (D, Llactide-co-glycolide)-poly (ethylene glycol)-poly (D, L-lactide-co-glycolide) (PLGA-PEG-PLGA) is a temperature-sensitive hydrogel that has a wide range of applications in drug delivery owing to its good biocompatibility and safety.…”