Lingonberry polyphenols: Potential SARS‐CoV‐2 inhibitors as nutraceutical tools?

Pärnänen, Pirjo; Lähteenmäki, Hanna; Räisänen, Ismo T.; Tervahartiala, Taina; Sorsa, Timo

doi:10.14814/phy2.14741

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Microbial proteases may modify these glycoproteins and cause pathogen entry. Lingonberry polyphenols show several antiviral mechanisms in vitro [54].…”

Section: Discussionmentioning

confidence: 99%

Effects of Fermented Lingonberry Juice Mouthwash on Salivary Parameters—A One-Year Prospective Human Intervention Study

et al. 2022

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A one-year prospective human intervention study was performed to examine the effects of fermented lingonberry juice (FLJ), used as a mouthwash for six months, on salivary parameters. A total of 25 adult participants used 10 mL of FLJ as mouthwash 30 s daily for 6 months in addition to their normal oral homecare routines. Standard oral examinations and gathering of samples were performed at the beginning of the study and after six months and one year. Resting and stimulated saliva secretion rates, resting saliva pH, and stimulated saliva buffering capacity were determined. A questionnaire of participants’ subjective sensations of mouth dryness was also recorded at each timepoint. Fermented lingonberry juice mouthwash had positive effect to all five salivary parameters and were, according to the omnibus test, statistically significant during the study period. Analysis of the subjective dry mouth sensation questionnaires revealed that symptoms of xerostomia decreased due to the use of FLJ. This study revealed that the once-a-day use of FLJ mouthwash had a beneficial, increasing effect on salivary flow rates, buffering capacity, and salivary pH. FLJ thus can be safely used as an adjunctive and beneficial therapy in oral homecare, protecting teeth and oral mucosa, including periodontium, and also relieving dry mouth symptoms.

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“…Microbial proteases may modify these glycoproteins and cause pathogen entry. Lingonberry polyphenols show several antiviral mechanisms in vitro [54].…”

Section: Discussionmentioning

confidence: 99%

Effects of Fermented Lingonberry Juice Mouthwash on Salivary Parameters—A One-Year Prospective Human Intervention Study

et al. 2022

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“…Several antimicrobial mechanisms of polyphenols have been proposed [36][37][38]. Lingonberry polyphenols have also been proposed to act as antivirals [39], and in this regard, lingonberries have been shown to possess in vitro antiviral activity [40]. Other studies have also reported lingonberry's antibacterial and antifungal activities: inhibition of growth of Candida, S. mutans, Porphyromonas gingivalis, Fusobacterium nucleatum, S. aureus, Salmonella enterica sv Typhimurium, S. epidermidis, P. gingivalis, P. intermedia, antiaggregation of S. mutans with Fusobacterium nucleatum or Actinomyces naeslundii, anti-adhesiveness of Neisseria meningitidis or oral streptococci in biofilm formation, and binding activity of Streptococcus pneumoniae, Streptococcus agalactiae and Streptococcus suis to berries and juices [36,[41][42][43][44][45][46][47][48][49][50][51][52].…”

Section: In Vitro Antimicrobial Studiesmentioning

confidence: 99%

Lingonberries—General and Oral Effects on the Microbiome and Inflammation

et al. 2021

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Lingonberry (Vaccinium vitis ideae L.) is a low-bush wild plant found in the northern hemisphere. The berries are used in traditional medicine in Finland to treat oral yeast infections. General and oral effects of lingonberries on the microbiome and inflammation are reviewed. A brief introduction to oral microbiome symbiosis and dysbiosis, innate and adaptive immunity and inflammation are included, and special features in microbe/host interactions in the oral environment are considered. In vitro anticancer, antimicrobial, antioxidant, anti-inflammatory, and in vivo mouse and human studies are included, focusing on the symbiotic effect of lingonberries on oral and general health.

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aMMP-8 point-of-care - diagnostic methods and treatment modalities in periodontitis and peri-implantitis

Lähteenmäki,

Pätilä,

Pärnänen

et al. 2023

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Lingonberry polyphenols: Potential SARS‐CoV‐2 inhibitors as nutraceutical tools?

Abstract: Proposed pathway of the effect of lingonberry polyphenols on oral microbial (viral) load reduction and consequent beneficial local and systemic (respiratory tract) anti‐inflammatory and antimicrobial/antiviral effects.

Cited by 3 publications

References 10 publications

Effects of Fermented Lingonberry Juice Mouthwash on Salivary Parameters—A One-Year Prospective Human Intervention Study

Effects of Fermented Lingonberry Juice Mouthwash on Salivary Parameters—A One-Year Prospective Human Intervention Study

Lingonberries—General and Oral Effects on the Microbiome and Inflammation

aMMP-8 point-of-care - diagnostic methods and treatment modalities in periodontitis and peri-implantitis

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