Lingual Frenulum Phenotypes in Brazilian Infants With Congenital Zika Syndrome

Fonteles, Cristiane Sá Roriz; Ribeiro, Erlane Marques; Santos, Marinisi Sales Aragão; Leite, Rebeka Ferreira Pequeno; Assunção, Gabryela Sales; Monteiro, André Jalles; Pessoa, André Luiz Santos; Giacheti, Célia Maria; Kerbage, Sáile Cavalcante Kerbage; Ribeiro, Thyciana Rodrigues; Cavalcanti, Luciano Pamplona de Góes

doi:10.1177/1055665618766999

Cited by 14 publications

(30 citation statements)

References 34 publications

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“…Published in 2017, a study conducted by medical geneticists and pediatric neurologists observed the absence of lingual frenulum in 4 (36.36%) out of 11 infants with the congenital Zika syndrome 19 . Conversely, a study conducted by SLPs reported that in a total of 54 infants with the congenital Zika syndrome, lingual frenulum visibility required a specific maneuver to retract the tongue in 20 (37%), since it was covered by mucous tissue 20 . The authors suggested the terminology "absent lingual frenulum" used by Del Campo et al 19 be replaced for "submucous lingual frenulum" 20 .…”

Section: Resultsmentioning

confidence: 98%

“…Thus, posterior lingual frenulum is an anatomical variation that may be present in both healthy infants 8 and infants with syndromes 20 . The special maneuver consisting of elevating and pushing the tongue back simultaneously is efficient, easy, and does not require any device for lingual frenulum assessment.…”

Section: Resultsmentioning

confidence: 99%

“…However, Fonteles et al reported that the absence of lingual frenulum was not observed in Brazilian infants with congenital Zika syndrome. Many of those newborns had submucosal frenulum, what could be misinterpreted as absent frenulum 20 .…”

Section: Introductionmentioning

confidence: 99%

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Posterior lingual frenulum in infants: occurrence and maneuver for visual inspection

Martinelli

Marchesan²,

Berretin-Felix

2018

Rev. CEFAC

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Purpose: to verify the occurrence of posterior or submucosal lingual frenulum and evaluate the efficiency of a special maneuver for its visual inspection. Methods: an experimental study including 1,715 healthy infants, in which prematurity, perinatal complications, craniofacial anomalies neurological disorders, and visible genetic syndromes were the exclusion criteria. A clinical examination was performed by means of a maneuver that consisted in rising the lateral margins of the tongue to visualize the anatomical characteristics of the lingual frenulum. In some of the infants, a special maneuver was performed to assist visualization of posterior lingual frenulum, since its visualization was not possible. The maneuver consisted in two simultaneous actions: elevating and pushing the tongue back. Results: 558 infants (32.54%), out of the 1,715 had posterior frenulum, which required the special maneuver that consisted in both elevating and pushing the tongue back, simultaneously. Conclusion: the occurrence of posterior lingual frenulum was high and the special maneuver consisted in elevating and pushing the tongue back proved to be efficient to visualize the posterior lingual frenulum.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

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Posterior lingual frenulum in infants: occurrence and maneuver for visual inspection

Martinelli

Marchesan²,

Berretin-Felix

2018

Rev. CEFAC

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“…Specificity. Although some outcomes, such as lingual phenotype 177 or neurogenic bladder 276 , have been hypothesised as a specific phenotype for congenital ZIKV infection, no additional evidence was identified that certain congenital adverse findings are specific for congenital ZIKV infection.…”

Section: Resultsmentioning

confidence: 99%

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

et al. 2019

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Background: The Zika virus (ZIKV) caused a large outbreak in the Americas leading to the declaration of a Public Health Emergency of International Concern in February 2016. A causal relation between infection and adverse congenital outcomes such as microcephaly was declared by the World Health Organization (WHO) informed by a systematic review structured according to a framework of ten dimensions of causality, based on the work of Bradford Hill. Subsequently, the evidence has continued to accumulate, which we incorporate in regular updates of the original work, rendering it a living systematic review. Methods: We present an update of our living systematic review on the causal relation between ZIKV infection and adverse congenital outcomes and between ZIKV and GBS for four dimensions of causality: strength of association, dose-response, specificity, and consistency. We assess the evidence published between January 18, 2017 and July 1, 2019. Results: We found that the strength of association between ZIKV infection and adverse outcomes from case-control studies differs according to whether exposure to ZIKV is assessed in the mother (OR 3.8, 95% CI: 1.7-8.7, I2=19.8%) or the foetus/infant (OR 37.4, 95% CI: 11.0-127.1, I2=0%). In cohort studies, the risk of congenital abnormalities was 3.5 times higher after ZIKV infection (95% CI: 0.9-13.5, I2=0%). The strength of association between ZIKV infection and GBS was higher in studies that enrolled controls from hospital (OR: 55.8, 95% CI: 17.2-181.7, I2=0%) than in studies that enrolled controls at random from the same community or household (OR: 2.0, 95% CI: 0.8-5.4, I2=74.6%). In case-control studies, selection of controls from hospitals could have biased results. Conclusions: The conclusions that ZIKV infection causes adverse congenital outcomes and GBS are reinforced with the evidence published between January 18, 2017 and July 1, 2019.

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“…The authors observed that all children had some form of dental manifestation, of which the most common were increased salivation, irritability, and gingival pruritus. Fonteles et al [17] evaluated the lingual frenulum of 54 children with CZS in Pernambuco and observed that many children had a posteriorly positioned lingual frenulum and, in some cases, the frenulum was hidden behind a mucous curtain.…”

Section: Dental Characteristics Of Czsmentioning

confidence: 99%

Dental care for children with Congenital Zika Syndrome

Siqueira¹,

Marinho²,

Santos

et al. 2020

RGO, Rev. Gaúch. Odontol.

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There was a large increase in the number of newborns with microcephaly in Brazil between 2015 and 2017, mainly in the Northeast. This increase was associated with intrauterine Zika virus infection, which causes a congenital syndrome characterized by neurological, musculoskeletal, and sensory abnormalities. Despite the great worldwide repercussion, few studies about oral conditions in children with the syndrome have been published. This work aims to propose a guide for the dental care of these individuals on the basis of a literature review. Children with congenital Zika syndrome have a number of systemic comorbidities that affect their oral health and can compromise dental care. To date, no clinical protocol has been established for the dental care of children with congenital Zika syndrome. This is a pioneering study of great importance to orient dental professionals and promote the dental health of these children.

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Lingual Frenulum Phenotypes in Brazilian Infants With Congenital Zika Syndrome

Abstract: Children with CZS showed predominance of a posterior lingual frenula covered by an overlapping curtain-like mucous membrane.

Cited by 14 publications

References 34 publications

Posterior lingual frenulum in infants: occurrence and maneuver for visual inspection

Posterior lingual frenulum in infants: occurrence and maneuver for visual inspection

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

Dental care for children with Congenital Zika Syndrome

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