Lingual Squamous Cell Carcinoma in Two Horses

Morrison, Megan; Groover, Erin S.; Schumacher, John; Newton, Joseph C.; Pereira, Mariano Mora

doi:10.1016/j.jevs.2019.05.022

Cited by 6 publications

(6 citation statements)

References 9 publications

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“…Similar to humans, PV infection and chronic inflammation are risk factors for development of genital precursor lesions and SCCs 4,11,30 . Reported cases of equine HSCCs are limited 15‐17,28,31,32 . Up to 100% of genital SCCs and precursor lesions and approximately 20% of HSCCs are associated with EcPV2 9,11,12,15,20 .…”

Section: Discussionmentioning

confidence: 99%

Equine papillomavirus type 2‐associated, carcinomatous lesions of the penis and laryngopharynx of an elderly Icelandic horse gelding

Lale¹,

Geyer²,

Jindra³

et al. 2022

Vet Record Case Reports

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A 28‐year‐old Icelandic horse gelding was presented with a laryngopharyngeal squamous cell carcinoma. The gelding had been treated for penile carcinoma in situ with a partial phallectomy 2 years earlier. Polymerase chain reaction of tumour DNA and subsequent amplicon sequencing revealed that the equine papillomavirus type 2 E6 oncogene sequences of both lesions were identical. There is strong evidence that equine papillomavirus type 2 is causally associated with genital squamous cell carcinomas and precancerous lesions. Recent reports indicate that equine papillomavirus type 2 might also play an active role in the pathogenesis of approximately 20% of equine squamous cell carcinomas in the oronasal, pharyngeal and laryngeal regions. To the authors’ knowledge, this is the first report of a horse consecutively developing a penile carcinoma in situ and a laryngopharyngeal squamous cell carcinoma that were apparently induced by the same equine papillomavirus type 2 variant. Possible equine papillomavirus type 2 infection pathways in this horse and the importance of early detection of lesions are discussed in this context.

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Section: Discussionmentioning

confidence: 99%

Equine papillomavirus type 2‐associated, carcinomatous lesions of the penis and laryngopharynx of an elderly Icelandic horse gelding

Lale¹,

Geyer²,

Jindra³

et al. 2022

Vet Record Case Reports

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“…There is little information about the survival time of head and neck SCC in horses. A case report described an 18 year-old American Saddlebred stallion with a SCC at the base of the tongue who received palliative radiation therapy and after initial clinical improvement was euthanized 7 weeks after (24). In another case report, partial excision of the incisive bone was performed in a 27-year-old Arabian stallion with a large oral SCC and showed no gross evidence of recurrence or metastasis 5 months later (6).…”

Section: Degree Of Keratinizationmentioning

confidence: 99%

Computed Tomographic and Histopathological Characteristics of 13 Equine and 10 Feline Oral and Sinonasal Squamous Cell Carcinomas

2020

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Squamous cell carcinoma (SCC) is the most common equine sinonasal and feline oral tumour. This study aimed to describe the computed tomographic and histopathological characteristics of equine and feline SCC. Thirteen horses and 10 cats that had been histopathologically diagnosed with oral or sinonasal SCC and had undergone computed tomography (CT) of the head were retrospectively included in the study. CT characteristics of the mass and involved structures were noted. Histological examinations were evaluated according to a human malignancy grading system for oral SCC, which considered four grades of increasing aggressiveness. In horses, the masses were at the levels of the paranasal sinuses (n = 8), mandible (n = 3), tongue (n = 1), and nasal cavity (n = 1). In cats, the masses were at the levels of the maxilla (n = 4), mandible (n = 3), tongue (n = 1), and buccal region (n = 1) and were diffusely distributed (facial and cranial bones; n = 1). Masses in the equine paranasal sinuses showed only mild, solid/laminar, periosteal reactions with variable cortical destruction. However, maxillary lesions in cats showed severe cortical destruction and irregular, amorphous/pumice stone-like, periosteal reactions. CT revealed different SCC phenotypes that were unrelated to the histological grade. For morphologic parameters of the tumour cell population, a variability for the degree of keratinization and number of mitotic cells was noted in horses and cats. Concerning the tumour-host relationship a marked, extensive and deep invasion into the bone in the majority of horses and cats was seen. Most cases in both the horses and cats were categorized as histological grade III (n = 8); four horses and one cat were categorized as grade IV, and one horse and one cat were categorized as grade II. In this study, we examined the diagnostic images and corresponding applied human histopathological grading of SCC to further elucidate the correlations between pathology and oral and sinonasal SCC imaging in horses and cats.

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“…This type of tumor in dogs has been reported in several organs, such as the cranium, cornea, rostral nasal septum, and oral cavity, while it has also occurred cutaneously (Dos Anjos et al, 2019;Simčič et al, 2020;Łojszczyk et al, 2021). Furthermore, SCC has been reported in other species, including cats, horses, and chinchillas (Thomson, 2007;Morrison et al, 2019;Szabo et al, 2019). The predisposing factors that cause SCC include exposure to ultraviolet light, contact with chemical carcinogens, chronic inflammation, and viral infection (Munday et al, 2017;Łojszczyk et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Recurrent Squamous Cell Carcinoma of the Submandibular Region after Surgery in a Dog: A Case Report

Lorsirigool¹,

Sudjaroen²,

Kulnides³

2021

WVJ

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Squamous cell carcinoma (SCC) is a malignant tumor that has been reported in several organs of different dog breeds. An 8-year-old Shih Tzu, an intact male dog, came to an animal clinic in the Thonburi area, Bangkok Province, Thailand, and a mass of 4.5 × 4.5 cm (width × length) by size was found at the submandibular area. Surgical excision to remove the mass and subsequent histological examination identified the mass as SCC. After conducting the surgery and follow-up, the mass was recurrent at the same location after 33 days and a dog died. Therefore, one of the possible reasons for the death of the dog could be SCC metastasis.

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Lingual Squamous Cell Carcinoma in Two Horses

Cited by 6 publications

References 9 publications

Equine papillomavirus type 2‐associated, carcinomatous lesions of the penis and laryngopharynx of an elderly Icelandic horse gelding

Equine papillomavirus type 2‐associated, carcinomatous lesions of the penis and laryngopharynx of an elderly Icelandic horse gelding

Computed Tomographic and Histopathological Characteristics of 13 Equine and 10 Feline Oral and Sinonasal Squamous Cell Carcinomas

Recurrent Squamous Cell Carcinoma of the Submandibular Region after Surgery in a Dog: A Case Report

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