Linguistic production and syntactic comprehension in schizophrenia and bipolar disorder

Perlini, Cinzia; Marini, Andrea; Garzitto, Marco; Isola, Miriam; Cerruti, Stefania; Marinelli, Veronica; Rambaldelli, Gianluca; Ferro, Adele; Tomelleri, Luisa; Dusi, Nicola; Bellani, Marcella; Tansella, Michele; Fabbro, Franco; Brambilla, Paolo

doi:10.1111/j.1600-0447.2012.01864.x

Cited by 62 publications

(59 citation statements)

References 66 publications

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“…These findings confirm that inter-hemispheric connectivity is hindered in both the disorders [7], representing a common neural underpinning of major psychoses [35][75][76]. The corpus callosum is known to play a fundamental role by modulating inter-hemispheric communication and cognitive processes [77][78]. In particular, the anterior callosal fibers connect the bilateral frontal cortices including the cortices associated with several cognitive domains such as memory, attention, and executive functions [78].…”

Section: Discussionsupporting

confidence: 62%

“…In particular, the anterior callosal fibers connect the bilateral frontal cortices including the cortices associated with several cognitive domains such as memory, attention, and executive functions [78]. The integrity of the corpus callosum is therefore crucial for sustained attention, context processing and language, which are frequently impaired in BD and SCZ [68][77][79]. …”

Section: Discussionmentioning

confidence: 99%

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Similar white matter changes in schizophrenia and bipolar disorder: A tract-based spatial statistics study

et al. 2017

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Several strands of evidence reported a significant overlapping, in terms of clinical symptoms, epidemiology and treatment response, between the two major psychotic disorders—Schizophrenia (SCZ) and Bipolar Disorder (BD). Nevertheless, the shared neurobiological correlates of these two disorders are far from conclusive. This study aims toward a better understanding of possible common microstructural brain alterations in SCZ and BD. Magnetic Resonance Diffusion data of 33 patients with BD, 19 with SCZ and 35 healthy controls were acquired. Diffusion indexes were calculated, then analyzed using Tract-Based Spatial Statistics (TBSS). We tested correlations with clinical and psychological variables. In both patient groups mean diffusion (MD), volume ratio (VR) and radial diffusivity (RD) showed a significant increase, while fractional anisotropy (FA) and mode (MO) decreased compared to the healthy group. Changes in diffusion were located, for both diseases, in the fronto-temporal and callosal networks. Finally, no significant differences were identified between patient groups, and a significant correlations between length of disease and FA and VR within the corpus callosum, corona radiata and thalamic radiation were observed in bipolar disorder. To our knowledge, this is the first study applying TBSS on all the DTI indexes at the same time in both patient groups showing that they share similar impairments in microstructural connectivity, with particular regards to fronto-temporal and callosal communication, which are likely to worsen over time. Such features may represent neural common underpinnings characterizing major psychoses and confirm the central role of white matter pathology in schizophrenia and bipolar disorder.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Similar white matter changes in schizophrenia and bipolar disorder: A tract-based spatial statistics study

et al. 2017

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“…Indeed, it has been consistently reported that psychosis is a trans-diagnostic dimension between in SZ and BD [62]. Both disorders share extensive similarities in terms of biological, clinical, genetic and neurocognitive factors, suggesting a continuous distribution of symptoms among the two disorders [62,63,64,65,66,67,68]. …”

Section: Discussionmentioning

confidence: 99%

The metabolic basis of cognitive insight in psychosis: A positron emission tomography study

et al. 2017

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The purpose of this study was to investigate the relationship between cognitive insight and cerebral metabolism in patients suffering from psychosis. The Beck Cognitive Insight Scale (BCIS) was administered to 63 patients with psychosis undergoing Positron Emission Tomography investigation. The sample was divided into two groups considering the BCIS score. Data were analyzed using Statistical Parametric Mapping. Results: patients with low insight, compared to those with high insight, showed decreased metabolism in the right fusiform gyrus, left precuneus, superior temporal gyrus and insula bilaterally, as well as increased metabolism in the left orbito-frontal gyrus (all p<0.005). Our results suggest that reduced posterior (occipito-temporo-insulo-parietal) and increased anterior (orbitofrontal) cerebral metabolism may sustain low cognitive insight in psychosis.

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“…Perlini et al . () investigated the per cent of global coherence errors produced during picture description by 30 individuals with schizophrenia, 30 individuals with bipolar disorder and control participants. They found significantly more global coherence errors among individuals with schizophrenia (9.3%) when compared with the healthy controls (4.2%).…”

Section: Resultsmentioning

confidence: 99%

Global coherence during discourse production in adults: a review of the literature

Ellis

Henderson

Wright

et al. 2016

Intl J Lang & Comm Disor

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Linguistic production and syntactic comprehension in schizophrenia and bipolar disorder

Abstract: Linguistic deficits have been detected in both groups of patients, being, however, more severe and generalized in schizophrenia than in bipolar disorder. Such results help us in improving our understanding of the potential psychopathological overlapping between these disorders.

Cited by 62 publications

References 66 publications

Similar white matter changes in schizophrenia and bipolar disorder: A tract-based spatial statistics study

Similar white matter changes in schizophrenia and bipolar disorder: A tract-based spatial statistics study

The metabolic basis of cognitive insight in psychosis: A positron emission tomography study

Global coherence during discourse production in adults: a review of the literature

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