Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Polysaccharides Suppressed Adipogenesis and Stimulated Lipolysis in HPA-v and 3T3-L1 Adipocytes

Bu, Su; Zheng, Huihua; Yuan, Chunying; Tian, Zhenle; Xu, Chunhua; Zhao, Linguo; Zhu, Ximeng; Chen, Hui

doi:10.1615/intjmedmushrooms.2020035861

Cited by 5 publications

(3 citation statements)

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“…The interaction between PPARγ and C/EBPα positively regulates adipocyte differentiation [84] . Compound 6 was found to inhibit cellular differentiation by reducing protein expression and mRNA transcription of PPARγ and C/EBPα, thereby decreasing cellular lipid accumulation [85] . Ganoderma lucidum polysaccharides could also inhibit adipocyte differentiation, which in turn inhibits lipid accumulation in 3T3-L1 adipocytes, promotes lipolysis, and regulates body lipolysis [86] .…”

Section: Modulation Of Pparγ Signaling Pathwaymentioning

confidence: 99%

The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

Hao,

Peng,

Guan

et al. 2024

Food &Amp; Medicine Homology

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Hyperlipidemia is a kind of lipid metabolism disease, whose pathogenesis is complex and diverse, mainly related to abnormal glucose and lipid metabolism, as well as insulin resistance and other characteristics. Because of their low toxic and side effects along with clear medicinal effects, the food and medicinal homological resources are widely used in the regulation of blood lipids in recent years. The State Administration for Market Regulation website and various databases have been searched for the use of food and medicinal homological materials in functional food products, the categories and frequency in food and medicinal homological resources, the lipid-lowering active ingredients and their mechanisms. The results showed that 53 kinds of food and medicinal homological resources were used to regulate blood lipids, of which Crataegus pinnatifida Bge., Cassia obtusifolia L., Nelumbo nucifera Gaertn., Morus alba L. and Pueraria lobata (Willd.) Ohwi were used most frequently. The main active ingredients are triterpenes and their glycosides, flavonoids, alkaloids and polysaccharides, etc., they regulated blood lipid levels and cholesterol metabolism by activating AMPK and PPARγ.

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Section: Modulation Of Pparγ Signaling Pathwaymentioning

confidence: 99%

The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

Hao,

Peng,

Guan

et al. 2024

Food &Amp; Medicine Homology

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show abstract

“…By stimulating AMPK phosphorylation, GLP promotes the phosphorylation of its downstream target ACC1, down-regulates adipocyte differentiation transcription factors PPARγ, C/ EBP-α, SREBPlc, some adipocyte genes ACC1, PLIN1, FASN and activated lipolysis gene HSL to inhibit fat formation and enhance lipolysis in adipocytes. This suggests that GLP has a good anti-fat effect and has the potential to be developed into anti-obesity products [44] . GLP activates cytokine-like and chemokine-like functions of human tissue stem cells/progenitors by regulating CAM expression and biological activity.…”

Section: Other Cellsmentioning

confidence: 99%

Pharmacological Effects and Related Mechanisms of Ganoderma Lucidum Polysaccharides at the Cellular Level

Zhang,

Song,

Zhao

et al. 2024

HSET

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Ganoderma lucidum polysaccharides are the primary active constituents of Ganoderma lucidum. Existing researches indicate that they possess multiple pharmacological effects and benefits, including anti-tumor, antioxidant, anti-aging, hypoglycemic, and immune-modulating properties. Studies on the cellular impact of Ganoderma polysaccharides have predominantly focused on various cell types, including malignant tumor cells, immune cells, cardiac myocytes, neurons, hepatocytes, and fibroblasts. In this paper, we review and summarize recent literature primarily related to these pharmacological effects at the cellular level and their underlying mechanisms. Our aim is to provide insights and references for the deep clinical development and utilization of Ganoderma lucidum polysaccharides.

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“…In China, the edible and medicinal fungi known commonly as mushroom, Ganoderma lucidum have been proven efficient in adipogenesis, lipolysis, and adipocyte being/browning. In HPA-v and 3T3-L1, the medicinal herb Ganoderma lucidum inhibits adipogenesis and promotes lipolysis [126]. In 3T3-L1 adipocytes, the concentrated extract of Prunus mume fruit inhibits adipogenesis and induces beijing, or browning [127].…”

Section: Common Naturally Occurring Biotherapies Used In the Preventi...mentioning

confidence: 99%

The heterogeneity of diabetes, a silent pandemic: the essence of one health approach and precision medicine in the fight against diabetes

Marshall¹,

Bu²

2023

Preprint

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Life is supported by metabolism, a vital physiological activity. It guarantees enough energy available to power every cellular activity. The primary cellular substrate, glucose, is where the majority of the energy needed by the cell to support all other life activities and the growth of living creatures is derived. The quality of life is greatly impacted by any disease or flaw that alters the metabolism of glucose. There is no known cure for the metabolic illness known as diabetes. As diabetes is so varied, the only effective treatments would be based on precision medicine and a molecular strategy. This review covers a wide range of topics, including the ability to recognize the various forms of diabetes, the anthropogenic and genetic influence of the cause of diabetes, the severity of the various forms of diabetes, its potential existential risk, the disease burden, and clinical methods for diagnosing them. The most recent research goes on to recommend ways to ameliorate the disease, including diet-based management, biotherapies, and other individual lifestyle choices. Futuristic therapy using molecular biology approach was suggested. Recent research found a direct correlation between an individual's lifestyle and the rate of gene mutation in diabetes. There is an existential risk associated with the sickness as the rate of the spread of the disease among population globally is faster than the world's population growth rate. It is possible to think of diabetes as a silent pandemic.

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Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Polysaccharides Suppressed Adipogenesis and Stimulated Lipolysis in HPA-v and 3T3-L1 Adipocytes

Cited by 5 publications

References 0 publications

The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

Pharmacological Effects and Related Mechanisms of Ganoderma Lucidum Polysaccharides at the Cellular Level

The heterogeneity of diabetes, a silent pandemic: the essence of one health approach and precision medicine in the fight against diabetes

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