Link between ACE I/D gene polymorphism and dyslipidemia in diabetic nephropathy: A case-control study from Hyderabad, India

Mahwish, Umme Najiya; Ponnaluri, Kamakshi Chaithri; Heera, Babi; Alavala, Satish Reddy; Devi, Kusuma; Raju, Sree Bhushan; Latha, G Suman; Jahan, Parveen

doi:10.4103/ijn.ijn_244_18

Cited by 11 publications

(6 citation statements)

References 30 publications

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“…Furthermore, we found a positive correlation between serum ACE level and HA1C was found (R= 0.232, p= 0.028) with negative correlation between ACE level and HDL (R= -0.305, p= 0.003). This supports the hypothesis that ACE activity has a role in insulin resistance and dyslipidemia [24,25] .…”

Section: Discussionsupporting

confidence: 87%

“…This conclusion is consistent with that of a research by Al-Saikhan et al [26] which found that diabetes patients had a statistically signi cant greater frequency of the DD genotypes than the healthy control group. In addition, Mahwish et al [25] study found that the DD genotype was statistically signi cantly more prevalent in the group of diabetic patients with nephropathy, with the DD genotypes conferring a 2.6-fold (95% CI=1.76-6.12; p=0.019) greater risk of progression to DN.…”

Section: Discussionmentioning

confidence: 96%

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Association between Angiotensin Converting Enzyme Gene I/D and Promoter Polymorphisms and Diabetic Nephropathy in Type2 Diabetic Patients in Ismailia, Egypt

Hassan,

Tolba,

Leheta

et al. 2023

Preprint

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BACKGROUND: There is mounting evidence that the chronic activation of renal and systemic ACE, which results in the production of Angiotensin II, is a critical step in the pathogenesis of DN. Chronic ACE activation causes an increase in intraglomerular pressure, tissue damage, pro-inflammatory effects, and promotes fibrosis. AIM: The purpose of this study was to determine if ACE polymorphisms (I/D rs4646994 and promoter SNP, rs4292) and ACE level were related to the DN development in T2DM patients in the Egyptian community. PATIENTS AND METHODS: This study is designed as a case control study which enrolled 90 subjects divided into three groups: 30 diabetic patients without DN, 30 diabetic patients with DN and 30 healthy individuals as control group. We measured for each patient the following: serum creatinine, eGFR, ACR, lipid prolife, HbA1C, as well as serum ACE level. Genotyping of ACE I/D and promoter SNP, rs4292, polymorphisms in ACE gene were performed using conventional PCR assays. RESULTS: The laboratory data analysis revealed that the only variables across the trial groups that indicated a significant statistical difference were serum creatinine, eGFR, ACR, HDL-C, LDL-C, and HbA1c. Total cholesterol and triglycerides did not. Between the study groups, there was a substantial statistical difference in the level of serum ACE. In our population, the genotype and allele frequencies of the ACE I/D gene polymorphism varied considerably between research groups, suggesting that it may be a risk factor for DN. In comparison to individuals of the wild type (II), the (DD) genotype considerably raised the probability of progression to T2DM by about six times and of progression to DN by about ten folds. This study found that the ACE promoter rs4292 (C/T) polymorphism is a risk factor for developing DN. The (TT) genotype is associated with increased susceptibility to DN as it was higher in diabetic patients with nephropathy than the two other study groups. However, there was no statistically significant difference in the study variables among different genotypes subgroups. CONCLUSION:According to our research, the mutant alleles (T) of the ACE promoter rs4292 (C/T) polymorphism and the ACE I/D rs4646994 polymorphism may both be risk factors for DN in the Egyptian population.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 96%

Association between Angiotensin Converting Enzyme Gene I/D and Promoter Polymorphisms and Diabetic Nephropathy in Type2 Diabetic Patients in Ismailia, Egypt

Hassan,

Tolba,

Leheta

et al. 2023

Preprint

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“…45 TG and TC were both independent risk factors for DN. 46,47 A network Mendelian randomization study showed a positive correlation between TG and CHD. 48…”

Section: Dovepressmentioning

confidence: 99%

<p>Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus</p>

Shi¹,

Niu²,

Wu³

et al. 2020

RMHP

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The study aimed to identify diseases that exhibit significant differences between hyperuricaemia (HUA) and non-hyperuricaemia (NHUA) groups and analyse the risk factors for HUA based on the related diseases in type 2 diabetes mellitus (T2DM). Methods: A total of 3264 T2DM patients were investigated from 2013 to 2017 in the Jinyang and Sanlin communities by obtaining basic data from the electronic medical record system (EMRS). From September 2018 to July 2019, 3000 patients (264 patients were missing during follow-up) were investigated with questionnaires, physical examinations and biochemical index tests. After removing missing values, 2899 patients were divided into HUA and NHUA groups. The chi-square test was used to identify diseases with differences. Using Lasso analysis and logistic regression analysis, risk factors for HUA based on the related diseases were obtained. The C-index, receiver operating characteristic (ROC) curve and calibration plot were used to validate the discrimination and accuracy of the factors. Results: The chi-square test showed that there were significant differences in coronary heart disease (CHD) and diabetic nephropathy (DN) between the HUA group and the NHUA group. Through Lasso regression, glycosylated haemoglobin A1c (HbA1c), triglyceride (TG), blood urea nitrogen (BUN) and serum creatinine (SCR) were screened in the CHD group. Body mass index (BMI), HbA1c, total cholesterol (TC), TG, BUN, SCR and urine microalbumin (UMA) were screened in the DN group. The P-value of all the variables was less than 0.05. Through the C-index, calibration, and ROC curve analyses, these risk factors had medium accuracy. Conclusion: HUA was significantly related to CHD and DN. The level of UA was correlated with HbA1c, TG, BUN, and SCR based on CHD. The level of UA was associated with BMI, HbA1c, TC, TG, BUN, SCR, and UMA based on DN.

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“…Various genetic variants and environmental factors are involved in the etiology of DKD. However, the exact mechanism regarding the pathophysiology of DKD remains unclear [7]. Clinical and epidemiological studies have shown that there is a family history of DKD in various ethnic groups, suggesting that genetic factors play a key role in developing the disease [8,9].…”

Section: Introductionmentioning

confidence: 99%

Role of engulfment and cell motility 1 (ELMO1) gene polymorphism in development of diabetic kidney disease

Omar

Zewain

Ghonaim

et al. 2021

Egypt J Med Hum Genet

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Background Diabetic kidney disease (DKD) is a progressive kidney disease that affects diabetic patients irrespective of glycemic state or hypertension. Therefore, early detection of DKD is of critical importance. Many genome-wide association studies have identified the engulfment and cell motility 1 (ELMO1) gene as a genetic marker linked to DKD. This study aimed to investigate the association between ELMO1 rs741301 gene polymorphism and the development of DKD among Egyptian patients with type 2 diabetes mellitus (T2DM). Allele and genotype frequencies were investigated in 304 subjects by real-time PCR allelic discrimination assay: 100 DKD patients, 102 diabetic patients without DKD, and 102 healthy controls. Results GG genotype of ELMO1 (rs741301) SNP and its allele frequencies were significantly high in all diabetic patients. GG genotype had an odds ratio (OR) of 6.095 and 95% confidence interval (CI) of 2.456–15.125, p < 0.001, while the frequent allele G had an OR of 2.366 and 95% CI of 1.450–3.859, p = 0.001. No significant difference was observed between T2DM without DKD and DKD. Conclusion Our results could not establish an association between the ELMO1 rs741301 variant and the progression of DKD.

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Link between ACE I/D gene polymorphism and dyslipidemia in diabetic nephropathy: A case-control study from Hyderabad, India

Cited by 11 publications

References 30 publications

Association between Angiotensin Converting Enzyme Gene I/D and Promoter Polymorphisms and Diabetic Nephropathy in Type2 Diabetic Patients in Ismailia, Egypt

Association between Angiotensin Converting Enzyme Gene I/D and Promoter Polymorphisms and Diabetic Nephropathy in Type2 Diabetic Patients in Ismailia, Egypt

<p>Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus</p>

Role of engulfment and cell motility 1 (ELMO1) gene polymorphism in development of diabetic kidney disease

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