Link between single nucleotide polymorphism of rs266729 and rs2241766 in the ADIPOQ gene and gestational diabetes in an Iranian population

Nezamzadeh, Fatemeh; Esmailkhani, Aylin; Edalati, Elahe; Hosseini, Seyedeh Saeedeh; Ghasemi, Ahmad; Bialvaei, Abed Zahedi; Taheri, Keyvan

doi:10.1016/j.genrep.2018.11.009

“…The G allele was associated with GDM in studies conducted in 130 Chinese women, 22 411 Polish women, 24 and 562 Iranian women. 54 In contrast to these findings, Beltcheva et al reported that the C allele was associated with GDM in a Bulgarian population. 23 Discrepancies between these studies may be due to BMI, stage of pregnancy, sample size and ethnicity, which are critical limitations of GDM associated genetic studies.…”

Section: Discussionmentioning

confidence: 85%

No Association Between ADIPOQ or MTHFR Polymorphisms and Gestational Diabetes Mellitus in South African Women

Dias¹,

Adam²,

Rheeder³

2021

DMSO

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Purpose Gestational diabetes mellitus (GDM) is a growing public health concern. GDM affects approximately 14% of pregnancies globally, and without effective treatment, is associated with short- and long-term complications in mother and child. Lower serum adiponectin (ADIPOQ) concentrations and aberrant DNA methylation have been reported during GDM. The aim of this study was to investigate the association between the ADIPOQ −11377C>G and −11391G>A, and methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphisms and GDM in a population of black South African women. Materials and Methods DNA was isolated from the peripheral blood of 447 pregnant women with (n=116) or without (n=331) GDM, where after ADIPOQ (rs266729 and rs17300539) and MTHFR (rs1801133) polymorphisms were genotyped using TaqMan Quantitative Real-Time PCR analysis. Results Women with GDM had a higher body mass index (p=0.012), were more insulin resistant (p<0.001) and had lower adiponectin levels (p=0.013) compared to pregnant women with normoglycemia. Genotypic, dominant and recessive genetic models showed no association between ADIPOQ rs266729 and rs17300539 and MTHFR rs1801133 polymorphisms and GDM. Intriguingly, the risk G allele of ADIPOQ rs266729 was associated with higher fasting glucose and insulin concentrations, while the T allele in MTHFR rs1801133 was associated with higher fasting insulin concentrations only. Conclusion ADIPOQ rs266729 and rs17300539 and MTHFR rs1801133 polymorphisms are not associated with GDM in a population of black South African women. These findings suggest that these single nucleotide polymorphisms (SNPs) do not individually increase GDM risk in the African population. However, the role of these SNPs in possible gene-gene or gene-environment interactions remain to be established.

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“…al. on Iranians refuted these results, concluding that T allele was the risk factor for GDM [12]. Contrary, other studies conducted on Arabs [13] and Bulgarians [14] were unable to nd any correlation between T45G SNP and GDM.…”

Section: Introductionmentioning

confidence: 86%

“…Reports with regards to the correlation of other genetic polymorphisms with GDM also vary among various population groups. Particularly, association studies about rs266729 of ADIPOQ gene have shown variable results as to whether G allele is a risk factor for GDM [12][15] or it can actually confer protection against the condition [14]. Previous studies about rs10811661 of CDKN2A/2B gene and GDM also indicated irregularities as other studies have established correlation [20] [21], while one study failed to identify any signi cant ndings [22].…”

Section: Introductionmentioning

confidence: 99%

ADIPOQ gene (T45G and G276T) single nucleotide polymorphisms and their association with gestational diabetes mellitus in a Filipino population

Fernandez

¹

,

Pineda-Cortel

²

2023

Preprint

1

0

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Several studies have associated the presence of ADIPOQ gene polymorphisms with insulin resistance, adiponectin levels, and metabolic diseases such as diabetes, although with varying degrees of correlation depending on ethnicity. Here we aim to identify individual’s susceptibility to gestational diabetes mellitus (GDM) in the presence of T45G and G276T single nucleotide polymorphisms (SNPs) within the ADIPOQ gene among Filipino pregnant women. A total of 285 pregnant women (95 GDM cases and 190 controls) were included in this study. Two ADIPOQ gene polymorphisms were genotyped using TaqMan assay. Results of SNP genotyping showed no significant differences in the frequencies of TT, TG and GG genotypes of T45G SNP between the GDM and control group [p = 1.0000, 0.6179, 0.5797; OR (95%CI) = 1.030 (0.582–1.874), 1.135 (0.683–1.828), 0.833 (0.481–1.420)]. Similarly, the frequencies of GG, GT, and TT genotypes of G276T SNP were comparable in both groups [p = 0.8002, 1.0000, 0.3466; OR (95%CI) = 1.090 (0.654–1.785), 1.022 (0.616–1.665), 0.433 (0.092–1.698)]. Moreover, although adiponectin levels were significantly decreased in GDM group (p = 0.0196) and have shown substantial negative correlations with FBS, 1-hour OGTT, 2-hour OGTT, and HOMA-IR (p < 0.05), they were not significantly different according to genotypes of T45G and G276T polymorphisms both in GDM and control group. Our results suggest that neither of the two ADIPOQ gene polymorphisms influence adiponectin levels and development of GDM in a Filipino population.

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“…Variations in the results of genetic association studies have been identified depending on population being studied. Although individual studies on Malaysian [ 8 ], Chinese [ 9 ], Iranian [ 10 ], and Han [ 11 ] populations have consistently correlated G allele and TG/GG genotype of T45G SNP of ADIPOQ gene with higher risk of GDM, findings in the recent study by Nezamzadeh, et al on Iranians refuted these results, concluding that T allele was the risk factor for GDM [ 12 ]. Contrary, other studies conducted on Arabs [ 13 ] and Bulgarians [ 14 ] were unable to find any correlation between T45G SNP and GDM.…”

Section: Introductionmentioning

confidence: 99%

“…Reports with regards to the correlation of other genetic polymorphisms with GDM also vary among various population groups. Particularly, association studies about rs266729 of ADIPOQ gene have shown variable results as to whether G allele is a risk factor for GDM [ 12 , 15 ] or it can actually confer protection against the condition [ 14 ]. Previous studies about rs10811661 of CDKN2A/2B gene and GDM also indicated irregularities as other studies have established correlation [ 20 , 21 ], while one study failed to identify any significant findings [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

ADIPOQ gene (T45G and G276T) single nucleotide polymorphisms and their association with gestational diabetes mellitus in a Filipino population

Fernandez,

Pineda-Cortel

2023

BMC Endocr Disord

0

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Several studies have associated the presence of ADIPOQ gene polymorphisms with insulin resistance, adiponectin levels, and metabolic diseases such as diabetes, although with varying degrees of correlation depending on ethnicity. Here we aim to identify individual’s susceptibility to gestational diabetes mellitus (GDM) in the presence of T45G and G276T single nucleotide polymorphisms (SNPs) within the ADIPOQ gene among Filipino pregnant women. A total of 285 pregnant women (95 GDM cases and 190 controls) were included in this study. Two ADIPOQ gene polymorphisms were genotyped using TaqMan assay. Results of SNP genotyping showed no significant differences in the frequencies of TT, TG and GG genotypes of T45G SNP between the GDM and control group [p = 1.0000, 0.6179, 0.5797; OR (95%CI) = 1.030 (0.582–1.874), 1.135 (0.683–1.828), 0.833 (0.481–1.420)]. Similarly, the frequencies of GG, GT, and TT genotypes of G276T SNP were comparable in both groups [p = 0.8002, 1.0000, 0.3466; OR (95%CI) = 1.090 (0.654–1.785), 1.022 (0.616–1.665), 0.433 (0.092–1.698)]. Moreover, although adiponectin levels were significantly decreased in GDM group (p = 0.0196) and have shown substantial negative correlations with FBS, 1-hour OGTT, 2-hour OGTT, and HOMA-IR (p < 0.05), they were not significantly different according to genotypes of T45G and G276T polymorphisms both in GDM and control group. Our results suggest that neither of the two ADIPOQ gene polymorphisms influence adiponectin levels and development of GDM in a Filipino population.

show abstract

Link between single nucleotide polymorphism of rs266729 and rs2241766 in the ADIPOQ gene and gestational diabetes in an Iranian population

Cited by 7 publications

References 29 publications

No Association Between ADIPOQ or MTHFR Polymorphisms and Gestational Diabetes Mellitus in South African Women

No Association Between ADIPOQ or MTHFR Polymorphisms and Gestational Diabetes Mellitus in South African Women

ADIPOQ gene (T45G and G276T) single nucleotide polymorphisms and their association with gestational diabetes mellitus in a Filipino population

ADIPOQ gene (T45G and G276T) single nucleotide polymorphisms and their association with gestational diabetes mellitus in a Filipino population

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