Linkage analysis of resistance to Streptococcus iniae infection in Japanese flounder (Paralichthys olivaceus)

Okamoto, Hiroyuki; Yamada, Toshiyuki; Matuyama, Tomomasa; Sakai, Takamitsu; Fuji, Kanako; Sakamoto, Takashi; Okamoto, Nobuaki; Yoshida, Kazunori; Hatori, Keita; Araki, Kazuo; Okauchi, Masanori

doi:10.1016/j.aquaculture.2010.07.039

Cited by 24 publications

(10 citation statements)

References 18 publications

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“…As an important approach to identify the underlying genes of the quantitative traits and develop the DNA markers associated with traits, QTL mapping has been conducted in some fish species, including Atlantic salmon 8 , rainbow trout 9 , Japanese flounder 10 and Asian seabass 11 . Some of these studies were performed for growth, the most important traits in aquaculture.…”

Section: Discussionmentioning

confidence: 99%

A genome scan revealed significant associations of growth traits with a major QTL and GHR2 in tilapia

Liu

Sun

Xia

et al. 2014

Sci Rep

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Growth is an important trait in animal breeding. However, the genetic effects underpinning fish growth variability are still poorly understood. QTL mapping and analysis of candidate genes are effective methods to address this issue. We conducted a genome-wide QTL analysis for growth in tilapia. A total of 10, 7 and 8 significant QTLs were identified for body weight, total length and standard length at 140 dph, respectively. The majority of these QTLs were sex-specific. One major QTL for growth traits was identified in the sex-determining locus in LG1, explaining 71.7%, 67.2% and 64.9% of the phenotypic variation (PV) of body weight, total length and standard length, respectively. In addition, a candidate gene GHR2 in a QTL was significantly associated with body weight, explaining 13.1% of PV. Real-time qPCR revealed that different genotypes at the GHR2 locus influenced the IGF-1 expression level. The markers located in the major QTL for growth traits could be used in marker-assisted selection of tilapia. The associations between GHR2 variants and growth traits suggest that the GHR2 gene should be an important gene that explains the difference in growth among tilapia species.

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Section: Discussionmentioning

confidence: 99%

A genome scan revealed significant associations of growth traits with a major QTL and GHR2 in tilapia

Liu

Sun

Xia

et al. 2014

Sci Rep

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“…As a result, many quantitative traits have complex inheritance patterns, but some traits can be largely determined by a few QTL with additive effects (Lynch & Walsh ). Driven by the potential for increased genetic gain in traits of economic importance, genetic linkage mapping and QTL mapping for growth (Guo, Li, Wang & Kong ), disease resistance (Moen, Sonesson, Hayes, Lien, Munck & Meuwissen ; Ozaki, Okamoto, Yamada, Matuyama, Sakai, Fuji, Sakamoto, Okamoto, Yoshida, Hatori, Araki & Okauchi ), environmental impact (Cnaani, Hallerman, Ron, Weller, Indelman, Kashi & Gall ) and other desirable traits (Drew, Schwabl, Wheeler & Thorgaard ) have been frequently applied to various aquatic organisms. To date, there are only a few studies on QTL affecting growth‐related traits in crustaceans (Li, Dierens, Byrne, Miggiano, Lehnert, Preston & Lyons .…”

Section: Introductionmentioning

confidence: 99%

Identification of quantitative trait loci for growth-related traits in the swimming crabPortunus trituberculatus

Liu

et al. 2013

Aquac Res

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The swimming crab (Portunus trituberculatus) is an economically important species in Asian aquaculture. Implementing growth-related traits of P. trituberculatus into genetic breeding programmes is an ongoing effort. We used a previously published genetic linkage map of P. trituberculatus, containing 55 simple sequence repeat (SSR) markers and 172 amplified fragment length polymorphism (AFLP) techniques to map quantitative trait loci (QTL) for growth-related traits in a single full sibling F 2 family. Ten growth-related traits were measured for QTL mapping. Composite interval mapping identified 9 QTL on the female map and 16 on the male map. Individual QTL with additive effects explained 11-38% of the phenotypic variance for various traits using the female parent's map, and from 1% to 21% using the male parent's map. Two QTL explaining a large percentage of variation in body weight were detected on chromosome 17 on the female map, and on chromosome 16 on the male map, and contributed 38% and 18% of the phenotypic variance respectively. This is the first study to report the detection and positioning of major QTL affecting growth in a true crab species (Brachyura). The mapping of growth-related QTL in this study raises the possibility of improving the growth of P. trituberculatus through markerassisted selection.

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“…Tilapia [149], seabream [150], red porgy [151], trout [151], flounder [152], barramundi [153], rabbitfish [154], hybrid striped bass [155], yellowtail [156] and catfish [157] Streptococcus dysgalactiae…”

Section: Streptococcosismentioning

confidence: 99%

“…S. iniae is responsible for a disease outbreak that killed 75% of hybrid tilapias (Tilapia niloticaÂTilapia aurea) in a Texas fish farm in USA in the early 1990s [237]. S. iniae is also the causative agent of disease outbreaks in seabream [150], red porgy [151], trout [151], flounder [152], barramundi [153], rabbitfish [154], yellowtail [156] and catfish [157]. The most extensively studied S. iniae vaccines are bacterins [238,239].…”

Section: Haemorrhagic Septicaemiamentioning

confidence: 99%

Major bacterial diseases in aquaculture and their vaccine development.

Pridgeon¹,

Klesius²

2012

CABI Reviews

145

115

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Aquaculture is emerging as the fastest growing food-producing industry in the world because of the increasing demand for food fish consumption. However, the intensive culture of food fish has led to outbreaks of various bacterial diseases, resulting in annual economic losses to the aquaculture industry estimated at billions of dollars worldwide. Feeding infected fish with antibiotic-medicated food is a general practice but has led to antibiotic resistance development in bacterial pathogen, resulting in a higher dose requirement for effective control, a matter of increasing public concern. Therefore, alternatives to antibiotics that give similar or enhanced protection to aquatic animals are urgently needed. Various vaccines have been developed recently to combat bacterial diseases in aquaculture. The purpose of this review is to summarize the major bacterial pathogens in aquaculture and the development of vaccines as alternatives to antibiotics to protect aquatic animals from these bacterial diseases.

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Linkage analysis of resistance to Streptococcus iniae infection in Japanese flounder (Paralichthys olivaceus)

Cited by 24 publications

References 18 publications

A genome scan revealed significant associations of growth traits with a major QTL and GHR2 in tilapia

A genome scan revealed significant associations of growth traits with a major QTL and GHR2 in tilapia

Identification of quantitative trait loci for growth-related traits in the swimming crabPortunus trituberculatus

Major bacterial diseases in aquaculture and their vaccine development.

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