Linkage between Particulate Matter Properties and Lung Function in Schoolchildren: A Panel Study in Southern China

Hu, Qiansheng; Ma, Xiaonan; Yue, Dingli; Dai, Jiajia; Zhao, Lu; Zhang, Dan; Ciren, Deji; Lin, Jianqing; You, Boning; Zhai, Yueyang; Yuan, Luan; Lin, Weiwei

doi:10.1021/acs.est.9b07463

Cited by 16 publications

(6 citation statements)

References 44 publications

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“…For example, exposure to sulfate, ammonium, EC, and/or OC fractions of PM 2.5 was adversely associated with pediatric emergency department visits for asthma and wheezing [22], and upper respiratory infections [23] among children in the United States. A panel study in Southern China also reported an association between OC and lung function decline in healthy school children [24]. Our previous study in the same city (Isahaya only) for adults with asthma showed consistent ndings that severe respiratory decline was associated with increased sulfate and OC fractions of PM 2.5 [7].…”

Section: Discussionsupporting

confidence: 52%

“…A major strength of this study was that we obtained a large number of daily PEF measurements over three years in the spring, while most previous panel studies investigating the associations with PM 2.5 exposures have been designed to collect lung function measurements over multiple days or a few months [24,[29][30][31][32]. The large number of PEF measurements in our study could increase the statistical power to detect a smaller effect size for the exposure-response associations among children with asthma, who are one of the most vulnerable populations to air pollution exposure.…”

Section: Discussionmentioning

confidence: 99%

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Respiratory function declines in children with asthma associated with chemical species of fine particulate matter (PM2.5) in Nagasaki, Japan

Kim

Park

et al. 2021

Preprint

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Background The differential effects of PM2.5 fractions on children’s lung function remain inconclusive. This study aimed to examine whether lung function in asthmatic children was associated with increased PM2.5 fractions in urban areas in Nagasaki prefecture, Japan, where the air pollution level is relatively low but influenced by transboundary air pollution. Methods We conducted a multiyear panel study of 73 asthmatic children (boys, 60.3%; mean age, 8.2 years) spanning spring 2014–2016 in two cities. We collected self-measured peak expiratory flow (PEF) twice a day and daily time-series data for PM2.5 total mass and its chemical species. We fitted a linear mixed effects model to examine short-term associations between PEF and PM2.5, adjusting for individual and time-varying confounders. A generalized linear mixed effects model was also used to estimate the association for worsening asthma defined by severe PEF decline. Back-trajectory and cluster analyses were used to investigate the long-range transboundary PM2.5 in the study areas. Results We found that morning PEFs were adversely associated with higher levels of sulfate (-1.61 L/min; 95% CI: -3.07, -0.15) in Nagasaki city and organic carbon (OC) (-1.02 L/min; 95% CI: -1.94, -0.09) in Isahaya city, per interquartile range (IQR) increase at lag1. In addition, we observed consistent findings for worsening asthma, with higher odds of severe PEF decline in the morning for sulfate (odds ratio (OR) = 2.31; 95% CI: 1.12, 4.77) and ammonium (OR = 1.73; 95% CI: 1.06, 2.84) in Nagasaki city and OC (OR = 1.51; 95% CI: 1.06, 2.15) in Isahaya city, per IQR increase at lag1. The significant chemical species were higher on days that could be largely attributed to the path of Northeast China origin (for sulfate and ammonium) or both the same path and local sources (for OC) than by other clusters. Conclusions This study provides evidence of the differential effects of PM2.5 fractions on lung function among asthmatic children in urban areas, where the Japanese national standards of air quality have been nearly met. Continuous efforts to promote mitigation actions and public awareness of hazardous transboundary air pollution are needed to protect susceptible children with asthma.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Respiratory function declines in children with asthma associated with chemical species of fine particulate matter (PM2.5) in Nagasaki, Japan

Kim

Park

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…For example, exposure to sulfate, ammonium, EC, and/or OC fractions of PM 2.5 was adversely associated with pediatric emergency department visits for asthma and wheezing [ 22 ], and upper respiratory infections [ 23 ] among children in the United States. A panel study in Southern China also reported an association between OC and lung function decline in healthy school children [ 24 ]. Our previous study in the same city (Isahaya only) for adults with asthma showed consistent findings that severe respiratory decline was associated with increased sulfate and OC fractions of PM 2.5 [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…A major strength of this study was that we obtained a large number of daily PEF measurements over three years in the spring, while most previous panel studies investigating the associations with PM 2.5 exposures have been designed to collect lung function measurements over multiple days or a few months [ 24 , 29 – 32 ]. The large number of PEF measurements in our study could increase the statistical power to detect a smaller effect size for the exposure-response associations among children with asthma, who are one of the most vulnerable populations to air pollution exposure.…”

Section: Discussionmentioning

confidence: 99%

Respiratory function declines in children with asthma associated with chemical species of fine particulate matter (PM2.5) in Nagasaki, Japan

Kim

Park

et al. 2021

Environ Health

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Background The differential effects of PM2.5 fractions on children’s lung function remain inconclusive. This study aimed to examine whether lung function in asthmatic children was associated with increased PM2.5 fractions in urban areas in Nagasaki prefecture, Japan, where the air pollution level is relatively low but influenced by transboundary air pollution. Methods We conducted a multiyear panel study of 73 asthmatic children (boys, 60.3%; mean age, 8.2 years) spanning spring 2014–2016 in two cities. We collected self-measured peak expiratory flow (PEF) twice a day and daily time-series data for PM2.5 total mass and its chemical species. We fitted a linear mixed effects model to examine short-term associations between PEF and PM2.5, adjusting for individual and time-varying confounders. A generalized linear mixed effects model was also used to estimate the association for worsening asthma defined by severe PEF decline. Back-trajectory and cluster analyses were used to investigate the long-range transboundary PM2.5 in the study areas. Results We found that morning PEFs were adversely associated with higher levels of sulfate (− 1.61 L/min; 95% CI: − 3.07, − 0.15) in Nagasaki city and organic carbon (OC) (− 1.02 L/min; 95% CI: − 1.94, − 0.09) in Isahaya city, per interquartile range (IQR) increase at lag1. In addition, we observed consistent findings for worsening asthma, with higher odds of severe PEF decline in the morning for sulfate (odds ratio (OR) = 2.31; 95% CI: 1.12, 4.77) and ammonium (OR = 1.73; 95% CI: 1.06, 2.84) in Nagasaki city and OC (OR = 1.51; 95% CI: 1.06, 2.15) in Isahaya city, per IQR increase at lag1. The significant chemical species were higher on days that could be largely attributed to the path of Northeast China origin (for sulfate and ammonium) or both the same path and local sources (for OC) than by other clusters. Conclusions This study provides evidence of the differential effects of PM2.5 fractions on lung function among asthmatic children in urban areas, where the Japanese national standards of air quality have been nearly met. Continuous efforts to promote mitigation actions and public awareness of hazardous transboundary air pollution are needed to protect susceptible children with asthma.

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“…Particulate matter with an aerodynamic diameter of 2.5 μm or less (PM 2.5 ) is one of the most harmful pollutants to lung health. Recently, several studies have shown that air pollution adversely affects lung function in children, adolescents, and adults ( 10 , 13 – 15 ). Furthermore, there is growing epidemiological evidence that long-term exposure to air pollution, especially PM 2.5 and nitrogen dioxide (NO 2 ), in healthy people or in people with certain chronic lung diseases, is associated with lower forced lung capacity (FVC) and forced expiratory volume in 1 s (FEV1) ( 11 , 12 , 16 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

Association of high PM2.5 levels with short-term and medium-term lung function recovery in patients with pulmonary lobectomy

Liu

Xiao

Huang

et al. 2022

Front. Public Health

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The association between exposure to ambient fine particulate matter with an aerodynamic diameter of ≤ 2.5 μm (PM2.5) and short- and medium-term lung function recovery (LFR) in patients undergoing lobectomy remains uncertain. This study investigated the associations between PM2.5 concentrations and LFR in adult patients (n = 526) who underwent video-assisted thoracoscopic (VATS) lobectomy in Guangzhou, China between January 2018 and June 2021. All patients underwent at least two spirometry tests. Environmental PM2.5 concentrations in the same period were collected from the nearest monitoring station. A multiple linear regression (MLR) model was employed to investigate the associations between changes in PM2.5 concentrations and LFR in patients who underwent lobectomy after adjusting for potential confounders. We assessed short- and medium-term LFR in patients who underwent lobectomy. The three- and 6-month average PM2.5 concentrations in each patient's residential area were divided into regional mild pollution (PM2.5 <25 μg/m3), moderate pollution (25 μg/m3 ≤ PM2.5 <35 μg/m3), and severe pollution (35 μg/m3 ≤ PM2.5) periods. The MLR model confirmed that PM2.5 was an independent risk factor affecting short-term forced lung capacity (FVC), forced expiratory volume in 1 s (FEV1), and maximum expiratory flow at 50% vital capacity (MEF50) recovery (adjusted P = 0.041, 0.014, 0.016, respectively). The MLR model confirmed that PM2.5 was an independent risk factor affecting medium-term MEF50 recovery (adjusted P = 0.046). Compared with the moderate and severe pollution periods, the short- and medium-term LFR (FVC, FEV1, MEF50) of patients in the mild pollution period were faster and better (P < 0.001, P < 0.001, P < 0.001, P = 0.048, P = 0.010, P = 0.013, respectively). Thus, exposure to high PM2.5 levels was associated with significantly reduced speed and degree of short- and medium-term LFR in patients who underwent lobectomy.

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Linkage between Particulate Matter Properties and Lung Function in Schoolchildren: A Panel Study in Southern China

Cited by 16 publications

References 44 publications

Respiratory function declines in children with asthma associated with chemical species of fine particulate matter (PM2.5) in Nagasaki, Japan

Respiratory function declines in children with asthma associated with chemical species of fine particulate matter (PM2.5) in Nagasaki, Japan

Respiratory function declines in children with asthma associated with chemical species of fine particulate matter (PM2.5) in Nagasaki, Japan

Association of high PM2.5 levels with short-term and medium-term lung function recovery in patients with pulmonary lobectomy

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