Linkage Disequilibrium Between TNF-α-308 G/A Promoter and Histocompatibility Leukocyte Antigen Alleles in Han-Nationality Lung Transplant Recipients From Eastern China

Mu, Hui-Jun; Ji, Zhang; Xie, Ping; Chen, Jingyu; Zhang, Bin

doi:10.6002/ect.2012.0099

Cited by 4 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tumor necrosis factor alpha ( TNFα )-308 G/A (rs1800629) A allele was previously reported to be positively associated with migraine in Asians (34). This allele, located on chromosome 6, is also linked with the haplotype HLA-A*33 - HLA-B*58 in Chinese (35,36). It is possible that the rs1800629 risk allele, instead of HLA-A*33:03 - HLA-B*58:01 - HLA-C*03:02 , is the causal variant.…”

Section: Discussionmentioning

confidence: 99%

HLA class I alleles are associated with clinic-based migraine and increased risks of chronic migraine and medication overuse

Huang¹,

Chen

Huang³

et al. 2020

Cephalalgia

View full text Add to dashboard Cite

Objective We aimed to evaluate associations of human leukocyte antigen variants with migraine or headache in hospital and population-based settings. Methods The case-control study population, aged 30–70, included 605 clinic-based migraine patients in a medical center and 8449 population-based participants in Taiwan Biobank (TWB). Clinic-based cases were ascertained by neurologists. Participants in Taiwan Biobank were interviewed by a structured questionnaire including headache and migraine history; among them, 2394 had headache or migraine history while 6055 were free of headache and served as controls. All subjects were genotyped by Axiom Genome-Wide Single Nucleotide Polymorphism Arrays and imputed for eight classical human leukocyte antigen genes. Human leukocyte antigen frequencies were compared between clinic-based and self-reported patients and controls. We utilized likelihood ratio tests to examine human leukocyte antigen-disease associations and logistic regressions to estimate the effect of human leukocyte antigen alleles on migraine. Results Human leukocyte antigen -B and C showed significant associations with clinic-based migraine ( q-value < 0.05). Human leukocyte antigen -B*39:01, human leukocyte antigen -B*51:01, human leukocyte antigen -B*58:01 and human leukocyte antigen -C*03:02 were significantly associated with migraine, with age and sex-adjusted odds ratios (95% CIs) of 1.80 (1.28–2.53), 1.50 (1.15–1.97), 1.36 (1.14–1.62) and 1.36 (1.14–1.62), correspondingly. Clinic-based migraineurs carrying human leukocyte antigen -B*58:01 or human leukocyte antigen -C*03:02 had 1.63 (1.11–2.39) -fold likelihood to have chronic migraine with medication-overuse headache compared to episodic migraine. However, no human leukocyte antigen genes were associated with self-reported headache or migraine in the community. Conclusions Human leukocyte antigen class I genetic variants are positively associated with risk of clinic-based migraine but not self-reported migraine or headache and may contribute to migraine chronification and medication overuse.

show abstract

Section: Discussionmentioning

confidence: 99%