Linkage of prion protein and scrapie incubation time genes

Carlson, George A.; Kingsbury, David T.; Goodman, Patricia A.; Coleman, Sherrie; Marshall, Susan T.; DeArmond, Stephen J.; Westaway, David; Prusiner, Stanley B.

doi:10.1016/0092-8674(86)90875-5

Cited by 386 publications

(204 citation statements)

References 29 publications

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“…This suggests that the C57BL/6J genes which code for a long incubation period are dominant over those of NZW/Sea and A/JJms which code for a short incubation. This finding is in keeping with data in reports on human familial cases of CJD (Masters et al, 1981) and host genotypes related to the scrapie incubation period (Dickinson & Meikle, 1971;Kingsbury et al, 1983;Carlson et al, 1986). However, the mean length of incubation period for NZW/Sea × B10.…”

Section: × C57bl/6j)supporting

confidence: 72%

“…However, in our studies on the relationship between incubation period and H-2 haplotypes, there was no positive correlation. It should be stressed that the H-2 complex has no apparent influence on the incubation period of CJD, as noted with scrapie in mice (Bruce & Dickinson, 1985;Carlson et al, 1986).…”

Section: × C57bl/6j)mentioning

confidence: 99%

“…The q allele at the D subregion of H-2 coded for shorter incubation periods whereas the d allele coded for longer ones. Thirdly, a single gene, Prn-i (prion 0000-8757 © 1989 SGM s. MOHRI AND J. TATEISHI incubation), with a profound effect on the incubation period of scruple was identified in mice after injection of the Chandler scrapie agent (Carlson et al, 1986). A study on the correlation between the murine prion protein sequence and length of scrapie incubation period suggested that the Prn-i gene was linked to or congruent with the murine prion protein gene (Prn-p) which encoded the prion protein.…”

Section: Introductionmentioning

confidence: 99%

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Host Genetic Control of Incubation Periods of Creutzfeldt-Jakob Disease in Mice

Mohri

Tateishi

1989

Journal of General Virology

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SUMMARYHost genetic control of the incubation period of Creutzfeldt-Jakob disease (CJD) was studied using various inbred strains of mice, including B10 congenic strains. Various incubation periods were found in mice injected either intracerebrally or intraperitoneally with the Fukuoka 1 strain of the CJD agent; NZW/Sea and A/JJms had the shortest, and BI0.AKM/OIa and C57BL/6J the longest, incubation periods. Length of the CJD incubation period did not correlate with the genetic markers tested, i.e. the murine major histocompatibility (H-2) complex (which has previously been reported to be linked to a gene influencing CJD incubation period in mice), coat colour or sex genes. In NZW/Sea × C57BL/6J F 1 hybrid mice the CJD incubation periods were similar to that of the parent with the longest incubation period. Incubation periods of the backcross progeny from F1 and NZW/Sea were intermediate between those of the parental mice and had a unimodal distribution pattern. A similar observation was made on the progeny of the A/JJms x C57BL/6J mating. On the other hand, the length of incubation period for the NZW/Sea x B10. AKM/Ola F1 hybrid fell between those for the two parents and the NZW/Sea x A/JJms F~ hybrid had a significantly longer incubation period than those of the two parents. These results suggest that polygenes probably control the length of the CJD incubation period in mice.

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Section: × C57bl/6j)supporting

confidence: 72%

Section: × C57bl/6j)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Host Genetic Control of Incubation Periods of Creutzfeldt-Jakob Disease in Mice

Mohri

Tateishi

1989

Journal of General Virology

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“…Recent reports have shown that a close linkage exists between the gene for PrP and a gene controlling scrapie incubation period in I/LnJ mice (Carlson et al, 1986) and in VM mice (Hunter et al, 1987). The incubation period gene has been designated Prn-i (Carlson et al, 1986) and is analogous to the Sinc gene described earlier (Dickinson et al, 1968). It has been suggested that this gene may determine both PrP genotype and incubation period (Carlson et al, 1986;Hunter et al, 1987).…”

mentioning

confidence: 99%

“…Some investigators have suggested that proteinase K-resistant, aggregated PrP 27-30 is the scrapie agent (Bolton et al, 1982;Prusiner, 1982). Recent reports have shown that a close linkage exists between the gene for PrP and a gene controlling scrapie incubation period in I/LnJ mice (Carlson et al, 1986) and in VM mice (Hunter et al, 1987). The incubation period gene has been designated Prn-i (Carlson et al, 1986) and is analogous to the Sinc gene described earlier (Dickinson et al, 1968).…”

mentioning

confidence: 99%