Linkage of the Cholesteryl Ester Transfer Protein (
            <i>CETP</i>
            ) Gene to LDL Particle Size

Talmud, Philippa J.; Edwards, Karen L.; Turner, Christopher J.; Newman, Beth; Palmen, Jutta; Humphries, Steve E.; Austin, Melissa A.

doi:10.1161/01.cir.101.21.2461

Cited by 60 publications

(21 citation statements)

References 47 publications

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“…Increased levels of sdLDL are highly atherogenic and increase the risk of CVD. A linkage of CETP locus to LDL particle size has been previously reported [34]. The I405V polymorphism has been reported to be associated with LDL size [7].…”

Section: Discussionmentioning

confidence: 91%

Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study

Todur

Ashavaid

2012

Ind J Clin Biochem

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There is an increasing interest to understand the molecular basis of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) subfractions and their association with coronary artery disease (CAD). The formation of these subfractions is greatly influenced by hepatic lipase (HL) and cholesteryl ester transfer protein (CETP) enzymes. To identify genetic markers influencing LDL and HDL subfractions and their role in CAD we performed a case-control genetic association study on 117 healthy controls and 119 angiographically verified CAD patients. Biochemical analysis was performed using standard assays. HDL-C and LDL-C subfractions were estimated using precipitation methods. Genotyping of C-514T (rs1800588) in the LIPC gene for HL and I405V (rs5882) in the CETP gene was done using PCR-based restriction enzyme analysis and sequencing. Both the polymorphisms were not associated with CAD. The C-514T was associated with increased HDL 3 -C levels in controls (P = 0.049). The I405V polymorphism was found to be associated with low levels of small dense, LDL (P = 0.038). A multiple regression analysis showed that the effects were dependent on gender and triglyceride levels. We conclude that these polymorphisms are not associated with CAD but are important determinants of HDL-C and small dense LDL particles in our population.

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Section: Discussionmentioning

confidence: 91%

Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study

Todur

Ashavaid

2012

Ind J Clin Biochem

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“…It has been demonstrated that cholesteryl ester transfer protein (CETP) is also an important determinant of LDL particle size 25,26) . In addition, lipoprotein lipase (LPL) activity and hepatic lipase activity have been shown to contribute to the formation of sd-LDL particles and could well represent significant determinants of LDL-peak particle diameter (LDL-PPD) in FH 27) .…”

Section: Discussionmentioning

confidence: 99%

Effects of Statin on Small Dense Low-Density Lipoprotein Cholesterol and Remnant-Like Particle Cholesterol in Heterozygous Familial Hypercholesterolemia

Nozue

Michishita

Ito

et al. 2008

JAT

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Aim:The effects of statin on small dense low-density lipoprotein cholesterol (sd-LDL-C) and remnant-like particle cholesterol (RLP-C) levels in heterozygous familial hypercholesterolemia (FH) have not been examined. This study aimed to clarify the effects of statin on sd-LDL-C and RLP-C levels in heterozygous FH. Methods: Seventeen patients with heterozygous FH were randomly assigned to 2 mg/day pitavastatin or 10 mg/day atorvastatin. At baseline and 12 weeks after treatment with statin, we measured sd-LDL-C and RLP-C levels.

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“…Cholesteryl ester transfer protein (CETP) plays a major role in the remodeling of lipoprotein particles by mediating the transfer of cholesteryl ester from HDL to apolipoprotein B (apoB)-containing lipoproteins in exchange for triglycerides, and several lines of evidence support the notion that CETP is linked to LDL size heterogeneity (4). Small, dense LDL particles have been associated with CAD in a number of studies (5)(6)(7).…”

mentioning

confidence: 99%

Relationship between cholesteryl ester transfer protein and LDL heterogeneity in familial hypercholesterolemia

Hogue

Lamarche

Gaudet³

et al. 2004

Journal of Lipid Research

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Small, dense LDL particles have been associated with an increased risk of coronary artery disease, and cholesteryl ester transfer protein (CETP) has been suggested to play a role in LDL particle remodeling. We examined the relationship between LDL heterogeneity and plasma CETP mass in familial hypercholesterolemia (FH). LDL particles were characterized by polyacrylamide gradient gel electrophoresis in a total of 259 FH heterozygotes and 208 nonFH controls. CETP mass was measured by enzyme-linked immunosorbent assay in a subgroup of 240 participants, which included 120 FH patients matched with 120 controls. As compared with controls, FH subjects had an 11% higher CETP mass. Moreover, LDL-peak particle diameter (LDL-PPD) was significantly smaller in FH heterozygotes than in controls (258.1 ؎ 4.8 vs. 259.2 ؎ 4.1 Å; P ‫؍‬ 0.01) after adjustment for covariates. There was also an inverse relationship between LDL-PPD and CETP mass ( R ‫؍‬ ؊ 0.15; P ‫؍‬ 0.02), and this relationship was abolished by adjustment for the FH/control status, indicating that LDL-PPD changes in FH are mediated, at least in part, by an increase in plasma CETP mass concentrations. These results suggest that increased plasma CETP mass concentrations could lead to significant LDL particle remodeling in FH heterozygotes and could contribute to the pathogenesis of atherosclerosis. -Hogue, J-C., B. Lamarche, D. Gaudet, M. Larivière, A. J. Tremblay, J. Bergeron, I. Lemieux, J-P. Després, C. Gagné, and P. Couture. Relationship between cholesteryl ester transfer protein and LDL heterogeneity in familial hypercholesterolemia.

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Linkage of the Cholesteryl Ester Transfer Protein ( CETP ) Gene to LDL Particle Size

Cited by 60 publications

References 47 publications

Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study

Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study

Effects of Statin on Small Dense Low-Density Lipoprotein Cholesterol and Remnant-Like Particle Cholesterol in Heterozygous Familial Hypercholesterolemia

Relationship between cholesteryl ester transfer protein and LDL heterogeneity in familial hypercholesterolemia

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