Linkage of the Pig Main Histocompatibility Complex and the J Blood Group System

Abstract

Linkage of the main histocompatibility complex (MHC) and the J blood group locus was demonstrated in pigs by means of segregation data in families of double back‐cross matings. A recombination frequency of 9.82% was estimated. No evidence of close association with the blood group systems A, B, D, E, F, G, H, I, K, L, M, N and O was found.

Serologically defined specificities of the pig main histocompatibility complex (SL‐A)

“…Transplantation studies showed that the SL-A complex is functionally distinct and is not identical with any blood group system. This was also confirmed by linkage studies in which independent segregation of SL-A on 13 erythrocyte loci was detected (Hruban et al, 1976). In these studies, however, linkage of SL-A and J erythrocyte locus was found, but still remained to confirm SL-A linkage to the C blood group locus, which seemed likely from the studies of Andresen & Bake: (1964), who detected linkage of J and C blood group markers.…”

“…1955). The same is valid for the SL-A and J blood group system in which the data were extended (Hruban et al, 1976). * x2 test comparison of the observed and the expected percentage.…”

“…Haplotypes were derived from the parental phenotypes and their segregation in the offspring. Double backcross (= test cross, GgTt X ggtt) families were used to detect SL-A linkage to the C erythrocyte locus and other single backcross (GgTt X Ttgg), double intercross (GgTt X GgTt) and double backcross (GgTt X ggtt) matings were used to supplement the data for linkage with the J blood group locus (Hruban et al, 1976). Linkage was detected by the 'lod score' method (Morton, 1955).…”

The halothane sensitivity locus and its linkage relationships

“…The report of loose linkage between the H locus and two other loci encoding red blood cell antigens -J and Chas led to speculation that the Hal linkage group might be on the same chromosome as the major histocompatibility complex (MHC) (Rasmusen, 1982). The C and J loci had previously been shown to be linked to each other and to the MHC ( S L A ) loci (Muir & Rasmusen, 1974;Hruban et al, 1976;Hradecky et al, 1982). The pig major histocompatibility complex has been mapped to chromosome 7 by in situ hybridization as well as by conventional linkage analysis between a chromosomal marker and the MHC (Geffrotin et al, 1984).…”