Linkage Relations of JK, CO, KEL and IGK with Each Other and with AHCY

Linkage analysis has been carried out in six German families with autosomal dominantly inherited myotonia congenita (Thomsen's disease) using five chromosome 19 markers known to be linked to the gene for myotonic dystrophy (DM). Two of the markers, APOC1 and APOC2, are tightly linked to DM. Close linkage between these markers and myotonia congenita (MC) has been excluded to a distance of 9 cM (z = -2.158). These data support the clinical suggestion that MC and DM are non-allelic disorders.

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Myotonia congenita (Thomsen's disease) excluded from the region of the myotonic dystrophy locus on chromosome 19

Koch

Harley

Sarfarazi

et al. 1989

Hum Genet

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Comparative map for mice and humans

Nadeau

Davisson²,

Doolittle³

et al. 1991

Mammalian Genome

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Comparative map for mice and humans

et al. 1992

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Linkage Relations of JK, CO, KEL and IGK with Each Other and with AHCY

Abstract: Linkage analyses of locus pairs involving IGK, JK, CO, KEL and AHCY resulted in altogether negative lod scores, thereby dwindling the reported linkage relations.

Cited by 3 publications

References 3 publications

Myotonia congenita (Thomsen's disease) excluded from the region of the myotonic dystrophy locus on chromosome 19

Myotonia congenita (Thomsen's disease) excluded from the region of the myotonic dystrophy locus on chromosome 19

Comparative map for mice and humans

Comparative map for mice and humans

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