Linkage relationships among 20 genetic markers in cattle Evidence for linkage between two pairs of blood group systems: B‐Z and S‐F/V respectively

Georges, Michel; Lathrop, Mark; Bouquet, Y; Hilbert, Pascale; Marcotte, Anne; Schwers, A.; Roupain, J; Vassart, Gilbert; Hanset, R.

doi:10.1111/j.1365-2052.1990.tb03213.x

Cited by 18 publications

(10 citation statements)

References 19 publications

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“…Further, the detection of genes influencing quantitative traits such as fertility traits is now feasible with the availability of a large number of genetic markers covering the genomes of different species (cattle –Fries et al. 1989; Georges et al. 1990; Barendse et al.…”

Section: Resultsmentioning

confidence: 99%

Male Reproductive Traits and Their Relationship to Reproductive Traits in Their Female Progeny: A Systematic Review

Burns

Gazzola²,

Holroyd³

et al. 2011

Reprod Domestic Animals

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The overall objective of one of the major research programs in the Co-operative Research Centre (CRC) for Beef Genetic Technologies is to 'Improve female reproductive performance' in tropical, northern Australian beef cattle herds. To address this overall objective, a quantitative genetics project focused on investigation of male reproductive traits was designed and linked to three female reproduction-focussed projects, (i) discovery of genes associated with post-partum re-conception and age at puberty; (ii) expression of genes associated with post-partum re-conception; and (iii) early predictors of lifetime female reproductive performance. During the initial planning of this male reproductive traits project, the CRC Scientific Review Committee recommended that the research team investigate and evaluate potentially new, early-life (i.e able to be measured before 2 years of age) predictors of both male and female reproductive performance. To address this recommendation, the following was carried out: (i) criteria for selection of traditional and candidate traits were established; (ii) methodology for tabulation of potential traits/phenotypes that define male and female reproductive function was developed; and (iii) a systematic scientific review of early-life predictors of male and female fertility was prepared. This review concluded that although factors that might be useful in predicting male reproductive performance have been studied for many years, there was relatively little useful information available to meet the objectives of this review. It was also concluded that the direction of future research should be guided not only by previous research which was scarce, but also by speculative hypotheses arising from an understanding of the physiological, endocrinological and genetic processes active in reproduction. A small number of new traits were recommended in addition to traditional sperm morphology, sexual behaviour, anatomical structure and growth traits. Potential additional traits include measurement of gonadotrophin-releasing hormone-stimulated luteinizing hormone (GnRH-stimulated LH); inhibin; several seminal plasma proteins (osteopontin, spermadhesin and seminal plasma proteins BSP30 and phospholipase A(2) could be used in an index); 11β-hydroxysteriod dehydrogenase; and leptin. In addition, the potential also exists to screen animals for a number of genetic markers associated with age of puberty, follicular recruitment and ovulation rate and genes associated with bovine seminal plasma protein and testosterone production. Insulin-like growth factor-1 (IGF-1) measurements are included because of their association with growth parameters, and an additional analysis demonstrated associations with male and female reproductive traits. Some of these factors have been previously evaluated in small numbers of animals of various species under intensive management conditions. Therefore, there is a need to evaluate these factors in much larger numbers of beef cattle grazing semi-extensive tropical production syste...

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Section: Resultsmentioning

confidence: 99%

Male Reproductive Traits and Their Relationship to Reproductive Traits in Their Female Progeny: A Systematic Review

Burns

Gazzola²,

Holroyd³

et al. 2011

Reprod Domestic Animals

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“…The class IIb subregion of the bovine MHC used to be defined genetically by mapping DYA, DYB, DIB, DOB, and LMP2 15-30 cM centromeric to DR and DQ (Andersson et al, 1988;Georges et al, 1990). A probe shown to contain the class IIb gene DYA was physically localized to BTA 23q12 → q13 (Skow et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Initially, this separation became evident by a high recombination frequency of 15-30 cM which was observed between the DYA, DYB, DIB, DOB, and LMP2 genes on one side and the DR and DQ genes on the other (Andersson et al, 1988;Georges et al, 1990;Stone and Muggli-Cockett, 1993;Shalhevet et al, 1995;van Eijk et al, 1995). Recombination analysis has further established that the DR and DQ genes, in turn, are tightly linked to MHC class I and class III genes (Andersson et al, 1988;Grosz et al, 1992;van Eijk et al, 1995;Beever et al, 1996).…”

mentioning

confidence: 99%

Physical assignment of the bovine MHC class IIa and class IIb genes

Hess

Goldammer

Gelhaus

et al. 1999

Cytogenet Genome Res

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Screening of a bovine yeast artificial chromosome (YAC) library revealed two clones which contain most of the class II genes of the major histocompatibility complex (MHC) known to date. The YACs were mapped by fluorescence in situ hybridization (FISH) and characterized for the class II genes they contain. We found that the classic class II genes BoLA- DQA, -DQB, -DRA, and -DRB3 are located at BTA 23q21 and the non-classic class II genes DYA, DIB, LMP2, LMP7, TAP2, BoLA-DOB, -DMA, -DMB, and -DNA are located at BTA 23q12→q13. These two different mapping locations confirm and extend previous findings of a gross physical distance between classic and non-classic MHC class II genes in cattle.

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“…The gene organization within this region also appears to be conserved between humans and swine, although a somewhat different organization of MHC genes has been observed in cattle and rodents. The bovine class II genes appear to be organized in two subregions that are -17 cM apart (Andersson et al 1988;Georges et al 1990;van Eijk et al 1993), although the overall order of gene classes is not known. In addition, the mouse and rat MHC contain class I genes on either side of the class II gene series (Widera and Flavell 1985).…”

Section: Sla Complexmentioning

confidence: 99%

Directed integration of the physical and genetic linkage maps of swine chromosome 7 reveals that the SLA spans the centromere.

Smith¹,

Rohrer²,

Alexander³

et al. 1995

Genome Res.

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The first integrated physical and genetic linkage map encompassing the entire swine chromosome 7 (SSC7) reveals that the porcine MHC (SLA) spans the centromere. A SLA class !I antigen gene lies on the q arm, whereas class I and !!1 genes lie on the p arm, suggesting that the presence of a centromere within the SLA does not preclude a functional complex. The SLA appears smaller than other mammalian MHC, as the genetic distance across two class !, three class !1, and three class !!i SLA gene markers is only I.I cM. There are significant variations in recombination rates as a function of position along the chromosome, and the SLA lies in the region with the lowest rate. Furthermore, the directed integration approach used in this study was more efficient than previous efforts that emphasized the screening of large insert libraries for random microsatellites.Genetic maps of livestock species are currently being developed to provide a worldwide resource for mapping quantitative trait loci, comparative mapping in evolutionary studies, and mapping of pertinent loci in animal models of human disorders. These objectives require a framework of informative markers that can be genotyped economically. Integration of this framework with a cytogenetic map allows evaluation of coverage, genome size, and recombination rates along the chromosome, as well as establishing syntenic relationships among species. Two linkage maps of swine chromosome 7 (SSC7) have been reported, one that includes 11 Archibald et al. 1995) and one with 17 ) microsatellite markers. The two maps have only one marker in common, and both contain intervals >30 cM. The cytogenetic map includes only four relatively low resolution assignments of linked markers with -30% coverage (Ed-

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Linkage relationships among 20 genetic markers in cattle Evidence for linkage between two pairs of blood group systems: B‐Z and S‐F/V respectively

Cited by 18 publications

References 19 publications

Male Reproductive Traits and Their Relationship to Reproductive Traits in Their Female Progeny: A Systematic Review

Male Reproductive Traits and Their Relationship to Reproductive Traits in Their Female Progeny: A Systematic Review

Physical assignment of the bovine MHC class IIa and class IIb genes

Directed integration of the physical and genetic linkage maps of swine chromosome 7 reveals that the SLA spans the centromere.

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