Linkage study of the glucagon receptor gene with type 2 diabetes mellitus in Italians

Gragnoli, Claudia; Milord, Edrice; Habener, Joel F.

doi:10.1016/j.metabol.2005.01.022

Cited by 13 publications

(9 citation statements)

References 12 publications

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“…Environmental and genetic factors play important roles in the mechanisms involved in the development of T2DM ( Bid et al, 2009 ). Studies on genes inducing susceptibility to T2DM have been carried out by various groups in different populations ( Almawi et al, 2006 , Gragnoli et al, 2005 , Grarup et al, 2007 , Herder et al, 2008 , Leak et al, 2008 , Tong et al, 2009 ).…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin D and vitamin D receptor gene polymorphisms with chronic inflammation, insulin resistance and metabolic syndrome components in type 2 diabetic Egyptian patients

Mackawy

Badawi

2014

Meta Gene

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BackgroundTo date the published data concerning the possible interplay between vitamin D (VitD) and Vit D receptor (VDR) gene polymorphism with the immune/inflammatory mediators in type 2 diabetes mellitus (DM) is insufficient. Some of the immune non-classical actions of vitamin D may point to its role in the pathogenesis of type 2 DM through down-regulation of cytokines (IL-6). Although there is evidence to support a relationship among vitamin D status, chronic inflammation and insulin resistance, the underlying mechanism requires further exploration. We aimed to investigate the role of vitamin D in chronic inflammation and insulin resistance in type 2 DM. Moreover, to examine the association of VDR gene polymorphisms [VDR 2228570 C > T (FokI); VDR 1544410 A > G (BsmI)] with the components of metabolic syndrome (MetSyn) in type 2 diabetic Egyptian patients .Subjects and methodsA total of 190 subjects were enrolled in this study, 60 controls and 130 type 2 diabetic patients (Group II). Group II was subdivided into 63 patients without MetSyn (subgroup IIa) and 67 patients with MetSyn (subgroup IIb). Genetic analysis for VDR gene polymorphisms was done in all subjects. VitD and IL-6 plasma levels were estimated.ResultsThe TT genotype for the VDR FokI was significantly more frequent in subgroup IIb than in subgroup IIa and controls (X2 = 6.83, P = 0.03 and X2 = 16.592, P = 0.000) respectively. The T allele was more frequent in the MetSyn group as compared to diabetics without MetSyn (p = 0.001), odds ratio (OR) and 95% CI for the T allele of C > T (FokI) = 2.30 (1.37–3.86). We did not detect any significant difference in VDR BsmI genotypes between patients and control groups (P = 0.947). FokI VDR was significantly associated with the lipid profile parameters, VitD and IL-6 plasma levels in subgroup IIa and associated with HOMA-IR, insulin, VitD, IL-6 levels, waist circumference (WC) and body mass index (BMI) in subgroup IIb while BsmI VDR variant was associated only with VitD values in both subgroups.ConclusionThe present study suggests an interaction between VDR polymorphisms and important components of MetSyn, VitD and pro-inflammatory cytokines (IL-6). FokI VDR polymorphisms may be linked to mild inflammation and insulin resistance and might represent a genetic determinant for developing MetSyn in type 2 diabetic Egyptian patients. The challenge is determining the mechanisms of VitD action for recommendation of VitD supplementation that reduces the risks of MetSyn, insulin resistance and progression to type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Association of vitamin D and vitamin D receptor gene polymorphisms with chronic inflammation, insulin resistance and metabolic syndrome components in type 2 diabetic Egyptian patients

Mackawy

Badawi

2014

Meta Gene

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“…[1][2][3][4][5][6][7][8][9] An association study of candidate genes, viz., fatty acid binding protein 2 (FABP2), uncoupling protein type 1 gene (UCP1), protein phosphatase type 1 (PP1G), β3 adrenergic receptor (β3AR), VDR, was carried out on T2DM patients in a migrant Indian population as well by Boullus-Sanchis et al [10] Genome-wide association studies have led to the identiÞ cation of several single nucleotide polymorphisms in genes such as CDKAL1, CDKN2B, HHEX/IDE, IGF2BP2, KCNJ11, SLC30A8, TCF2, TCF7L2 and WFS1. [11] Several genes were studied but only a handful showed conÞ rmed association, such as resistin, alpha-endosulfine, calpain10, peroxisome proliferators-activated receptor-gamma 2 (PPARγ-2), abundant transcript 1 gene (apM1), TCF7L2, insulin-like growth factor-binding protein 5 (IGFBP5), to name a few.…”

Section: Subject Selectionmentioning

confidence: 99%

Vitamin D receptor (FokI, BsmI and TaqI) gene polymorphisms and type 2 diabetes mellitus : A North Indian study

Bid¹,

Konwar²,

Aggarwal

et al. 2009

Indian J Med Sci

119

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“…To date, few genetic studies have been performed in late‐ and early‐onset T2D in Italians (Gragnoli et al, 1997, 2001, 2005a,b; Milord and Gragnoli, 2006; Milord and Gragnoli, 2007; Gragnoli and Cronsell, 2007a,b,c). Therefore, it is important to genotype Italian T2D patients to delineate the genetic components of T2D in the Italian population offering knowledge on the chromosomal pool and genes contributing to disease onset.…”

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confidence: 99%

Squamous cell carcinoma of the nasal vestibule 1993–2002: A nationwide retrospective study from DAHANCA

et al. 2009

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Linkage study of the glucagon receptor gene with type 2 diabetes mellitus in Italians

Cited by 13 publications

References 12 publications

Association of vitamin D and vitamin D receptor gene polymorphisms with chronic inflammation, insulin resistance and metabolic syndrome components in type 2 diabetic Egyptian patients

Association of vitamin D and vitamin D receptor gene polymorphisms with chronic inflammation, insulin resistance and metabolic syndrome components in type 2 diabetic Egyptian patients

Vitamin D receptor (FokI, BsmI and TaqI) gene polymorphisms and type 2 diabetes mellitus : A North Indian study

Squamous cell carcinoma of the nasal vestibule 1993–2002: A nationwide retrospective study from DAHANCA

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