Linking bone cells, aging, and oxidative stress: Osteoblasts, osteoclasts, osteocytes, and bone marrow cells

Ardura, Juan A.; Álvarez-Carrión, Luis; Gortázar, Arancha R.; Alonso, V.

doi:10.1016/b978-0-12-818698-5.00006-7

Cited by 4 publications

(9 citation statements)

References 54 publications

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“…These deficiencies contribute to the development of male osteoporosis owing to the central role of these sex hormones (mainly estrogen) in male bone homeostasis and maintaining a balanced reactive oxygen species (ROS) level through decreasing oxidative stress [55,56]. Moreover, oxidative stress can trigger the proliferation of hematopoietic stem cells (HSCs) and MSCs [57] while boosting osteoclast differentiation [9] and diverting MSCs differentiation towards the adipogenic lineage [58].…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress occurs when the production of reactive oxygen/nitrogen species overrides the level of antioxidants, increasing the susceptibility for osteoporosis. GC can boost the generation of these reactive species, distorting bone remodeling and creating an imbalance between osteoclast and osteoblast, leading to osteoporosis [7,9]. Furthermore, oxidative stress can induce the apoptosis of osteoblasts and osteocytes while activating preosteoclasts differentiation.…”

Section: Introductionmentioning

confidence: 99%

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Phoenix dactilyfera L. Pits Extract Restored Bone Homeostasis in Glucocorticoid-Induced Osteoporotic Animal Model through the Antioxidant Effect and Wnt5a Non-Canonical Signaling

et al. 2022

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Oxidative stress associated with long-term glucocorticoids administration is a route through which secondary osteoporosis can be developed. The therapeutic potential of Phoenix dactilyfera L. pits is offered by their balanced, valuable and diverse phytochemical composition providing protective potential against oxidative reactions, making it a good candidate to treat glucocorticoid-induced osteoporosis (GIO). This study evaluates the possible anti-osteoporotic effect of date pit extract (DPE) against dexamethasone (DEXA)-induced osteoporosis. Male rats were allocated into three control groups, which received saline, low and high doses of DPE (150 and 300 mg/kg/day), respectively. Osteoporosis-induced groups that received DEXA (1 mg/kg/day) were divided into DEXA only, DPE (2 doses) + DEXA, and ipriflavone + DEXA. Femoral bone minerals density and bone mineral content, bone oxidative stress markers, Wnt signaling, osteoblast and osteoclast differentiation markers, and femur histopathology were evaluated. DPE defeated the oxidative stress, resulting in ameliorative changes in Wnt signaling. DPE significantly reduced the adipogenicity and abolished the osteoclastogenic markers (RANKL/OPG ratio, ACP, TRAP) while enhancing the osteogenic differentiation markers (Runx2, Osx, COL1A1, OCN). In Conclusion DPE restored the balanced proliferation and differentiation of osteoclasts and osteoblasts precursors. DPE can be considered a promising remedy for GIO, especially at a low dose that had more potency.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phoenix dactilyfera L. Pits Extract Restored Bone Homeostasis in Glucocorticoid-Induced Osteoporotic Animal Model through the Antioxidant Effect and Wnt5a Non-Canonical Signaling

et al. 2022

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“…Oxidative stress-induced apoptosis of osteoblasts plays an important role in the pathological process of osteoporosis. 3 Therefore, reducing the ROS level in osteoblasts could be an important means to prevent osteoporosis. As shown in Figure 4A, H 2 O 2 treatment significantly increased ROS levels in MC3T3-E1 cells (P < 0.05).…”

Section: Mass Spectroscopy Analysis Of the F3−15 Fractionmentioning

confidence: 99%

“…In recent years, with the presence of an aging society, research on methods to prevent and mitigate ROS-induced osteoporosis or other related bone metabolic disorders has been increasingly investigated. 3 One effective method is the supplementation of antioxidants. 8 Bioactive peptides are commonly employed in research investigations involving anti-inflammatory, antioxidant, and antiallergic effects, because of their diversity of sources, ease of absorption, safety, and nontoxicity.…”

Section: ■ Introductionmentioning

confidence: 99%

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Novel Peptides from Sturgeon Ovarian Protein Hydrolysates Prevent Oxidative Stress-Induced Dysfunction in Osteoblast Cells: Purification, Identification, and Characterization

Gao,

Zhu,

Zhang

et al. 2024

J. Agric. Food Chem.

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This study aimed to explore antioxidant peptides derived from sturgeon (Acipenser schrenckii) ovaries that exhibit antiosteoporotic effects in oxidative-induced MC3T3-E1 cells. The F3−15 component obtained from sturgeon ovarian protein hydrolysates (SOPHs) via gel filtration and RP-HPLC significantly increased the cell survival rate (from 49.38 ± 2.88 to 76.26 ± 2.09%). Two putative antioxidant-acting peptides, FDWDRL (FL6) and FEGPPFKF (FF8), were screened from the F3−15 faction via liquid chromatography−tandem mass spectrometry (LC−MS/MS) and through prediction by computer simulations. Molecular docking results indicated that the possible antioxidant mechanisms of FL6 and FF8 involved blocking the active site of human myeloperoxidase (hMPO). The in vitro tests showed that FL6 and FF8 were equally adept at reducing intracellular ROS levels, increasing the activity of antioxidant enzymes, and protecting cells from oxidative injuries by inhibiting the mitogen-activated protein kinase (MAPK) pathway and activating the phosphoinositide-3 kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3β (GSK-3β) signaling pathway. Moreover, both peptides could increase differentiation and mineralization abilities in oxidatively damaged MC3T3-E1 cells. Furthermore, FF8 exhibited high resistance to pepsin and trypsin, showcasing potential for practical applications.

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Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects

et al. 2023

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In this review, we explore the application of novel biomaterial-based therapies specifically targeted towards craniofacial bone defects. The repair and regeneration of critical sized bone defects in the craniofacial region requires the use of bioactive materials to stabilize and expedite the healing process. However, the existing clinical approaches face challenges in effectively treating complex craniofacial bone defects, including issues such as oxidative stress, inflammation, and soft tissue loss. Given that a significant portion of individuals affected by traumatic bone defects in the craniofacial area belong to the aging population, there is an urgent need for innovative biomaterials to address the declining rate of new bone formation associated with age-related changes in the skeletal system. This article emphasizes the importance of semiconductor industry-derived materials as a potential solution to combat oxidative stress and address the challenges associated with aging bone. Furthermore, we discuss various material and autologous treatment approaches, as well as in vitro and in vivo models used to investigate new therapeutic strategies in the context of craniofacial bone repair. By focusing on these aspects, we aim to shed light on the potential of advanced biomaterials to overcome the limitations of current treatments and pave the way for more effective and efficient therapeutic interventions for craniofacial bone defects.

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Linking bone cells, aging, and oxidative stress: Osteoblasts, osteoclasts, osteocytes, and bone marrow cells

Cited by 4 publications

References 54 publications

Phoenix dactilyfera L. Pits Extract Restored Bone Homeostasis in Glucocorticoid-Induced Osteoporotic Animal Model through the Antioxidant Effect and Wnt5a Non-Canonical Signaling

Phoenix dactilyfera L. Pits Extract Restored Bone Homeostasis in Glucocorticoid-Induced Osteoporotic Animal Model through the Antioxidant Effect and Wnt5a Non-Canonical Signaling

Novel Peptides from Sturgeon Ovarian Protein Hydrolysates Prevent Oxidative Stress-Induced Dysfunction in Osteoblast Cells: Purification, Identification, and Characterization

Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects

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