Linking Education to Action: A Program to Increase Research Participation Among African American Women

Breitkopf, Carmen Radecki; Williams, Karen Patricia; Ridgeway, Jennifer L.; Parker, Monica W.; Strong-Simmons, Alice; Hayes, Sharonne N.; Halyard, Michele Y.

doi:10.1089/jwh.2017.6791

Cited by 8 publications

(13 citation statements)

References 35 publications

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“…It is well documented that NHB women are more likely to be diagnosed with TNBC and are most likely to die from breast cancer compared to all other ethnic groups 2,4,12,15,16 . However, NHB women are underrepresented in breast cancer research studies 17,18 , including studies investigating the breast microbiome. Our study is the first to show differences in the breast tissue microbiota between NHB and NHW women.…”

Section: Discussionmentioning

confidence: 99%

Distinct microbial communities that differ by race, stage, or breast-tumor subtype in breast tissues of non-Hispanic Black and non-Hispanic White women

Smith

Pierre

Makowski

et al. 2019

Sci Rep

111

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Growing evidence highlights an association between an imbalance in the composition and abundance of bacteria in the breast tissue (referred as microbial dysbiosis) and breast cancer in women. However, studies on the breast tissue microbiome have not been conducted in non-Hispanic Black (NHB) women. We investigated normal and breast cancer tissue microbiota from NHB and non-Hispanic White (NHW) women to identify distinct microbial signatures by race, stage, or tumor subtype. Using 16S rRNA gene sequencing, we observed that phylum Proteobacteria was most abundant in normal (n = 8), normal adjacent to tumor (normal pairs, n = 11), and breast tumors from NHB and NHW women (n = 64), with fewer Firmicutes, Bacteroidetes, and Actinobacteria. Breast tissues from NHB women had a higher abundance of genus Ralstonia compared to NHW tumors, which could explain a portion of the breast cancer racial disparities. Analysis of tumor subtype revealed enrichment of family Streptococcaceae in TNBC. A higher abundance of genus Bosea (phylum Proteobacteria) increased with stage. This is the first study to identify racial differences in the breast tissue microbiota between NHB and NHW women. Further studies on the breast cancer microbiome are necessary to help us understand risk, underlying mechanisms, and identify potential microbial targets.

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Section: Discussionmentioning

confidence: 99%

Distinct microbial communities that differ by race, stage, or breast-tumor subtype in breast tissues of non-Hispanic Black and non-Hispanic White women

Smith

Pierre

Makowski

et al. 2019

Sci Rep

111

View full text Add to dashboard Cite

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“…However, CBA focus on broad methods for recruitment and less on message content. Existing studies also have reported on the use of educational materials and seminars to improve African American recruitment (Skinner et al, 2008; Halverson and Ross, 2012; Rodriguez et al, 2016; Radecki Breitkopf et al, 2018). Studies found pre-post increases in knowledge about genomic studies, more favorable attitudes (Patel et al, 2018) and less negative affect (Kiviniemi et al, 2013) after receiving an educational intervention.…”

Section: Introductionmentioning

confidence: 99%

A Review of African Americans’ Beliefs and Attitudes About Genomic Studies: Opportunities for Message Design

et al. 2019

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Precision Medicine, the practice of targeting prevention and therapies according to an individual’s lifestyle, environment or genetics, holds promise to improve population health outcomes. Within precision medicine, pharmacogenomics (PGX) uses an individual’s genome to determine drug response and dosing to tailor therapy. Most PGX studies have been conducted in European populations, but African Americans have greater genetic variation when compared with most populations. Failure to include African Americans in PGX studies may lead to increased health disparities. PGX studies focused on patients of African American descent are needed to identify relevant population specific genetic predictors of drug responses. Recruitment is one barrier to African American participation in PGX. Addressing recruitment challenges is a significant, yet potentially low-cost solution to improve patient accrual and retention. Limited literature exists about African American participation in PGX research, but studies have explored barriers and facilitators among African American participation in genomic studies more broadly. This paper synthesizes the existing literature and extrapolates these findings to PGX studies, with a particular focus on opportunities for message design. Findings from this review can provide guidance for future PGX study recruitment.

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“… 3 , 4 Despite this underrepresentation, previous studies have shown that AAs have an interest to participate in a variety of medical research studies beyond traditional clinical trials including medical record review, interview, and biobank/genetic studies. 5 , 6 The failure to create a more racially diverse research cohort perpetuates existing health and healthcare disparities which disproportionately affect AAs.…”

Section: Introductionmentioning

confidence: 99%

Overcoming Historical Barriers: Enhancing Positive Perceptions of Medical Research Among African Americans Through a Conference-Based Workshop

et al. 2021

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Background African Americans (AAs) and other racial/ethnic minority groups continue to be underrepresented in medical research and clinical trials. Failure to create more racially diverse research cohorts can exacerbate existing health disparities among these groups. Objective To investigate best practices and strategies for enhancing participation of AAs in medical research among attendees of a preconference Institute at a faith-based public health conference. Design Qualitative study using semi-structured interviews. Participants A total of 21 out of 29 attendees (90% AA) of the Institute (72% response rate). Approach A culturally tailored preconference Institute was held at the 2017 Healthy Churches 2020 National Conference. The Institute was led by AA researchers focused on underrepresentation of AAs in medical research. Semi-structured interviews were conducted 1-year post-Institute (n=21) and were audio-recorded, transcribed verbatim, and reviewed using thematic analysis. Key Results The majority of attendees reported that they were more likely to participate in medical research after attending the Institute (75%). Salient learning points reported by attendees demonstrated attainment of the Institute objectives. Key themes emerged describing barriers preventing AAs from participating in medical research including fear/lack of trust, lack of information on research projects, and not being approached to participate. Key themes regarding facilitators for participation in medical research by AAs were clear communication of study objectives and research benefits along with trust in researchers. Conclusions Attendees’ perceptions of participation in medical research were largely positive following their attendance at a conference-based Institute aimed to address the underrepresentation of AAs in medical research. Our culturally tailored approach to disseminating knowledge of the research process could extend to other national conferences prioritizing AAs and other racial/ethnic minority populations to improve research participation.

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Linking Education to Action: A Program to Increase Research Participation Among African American Women

Abstract: An online education-to-action program targeting professional African American women improved knowledge, perceptions of ethics, and intent to participate in biomedical research.

Cited by 8 publications

References 35 publications

Distinct microbial communities that differ by race, stage, or breast-tumor subtype in breast tissues of non-Hispanic Black and non-Hispanic White women

Distinct microbial communities that differ by race, stage, or breast-tumor subtype in breast tissues of non-Hispanic Black and non-Hispanic White women

A Review of African Americans’ Beliefs and Attitudes About Genomic Studies: Opportunities for Message Design

Overcoming Historical Barriers: Enhancing Positive Perceptions of Medical Research Among African Americans Through a Conference-Based Workshop

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