Linking Nonalcoholic Fatty Liver Disease to Hepatocellular Carcinoma:                     From Bedside to Bench and Back

Yılmaz, Yusuf; Çolak, Yaşar; Kurt, Ramazan; Şenateş, Ebubekir; Eren, Fatih

doi:10.1177/030089161309900102

Cited by 11 publications

(6 citation statements)

References 83 publications

(92 reference statements)

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“…In accordance with these findings, there is a large body of evidence showing that regular exercise reduces the risk of life-style related diseases [29], [32], [5], [56], [65], increases mean life-span [12] and, significantly increases the quality of life, especially in the elderly [18], [9]. It is important to note that the effects of exercise are systemic and complex [44].…”

Section: Introductionmentioning

confidence: 73%

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

et al. 2017

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It is debated whether exercise-induced ROS production is obligatory to cause adaptive response. It is also claimed that antioxidant treatment could eliminate the adaptive response, which appears to be systemic and reportedly reduces the incidence of a wide range of diseases. Here we suggest that if the antioxidant treatment occurs before the physiological function-ROS dose-response curve reaches peak level, the antioxidants can attenuate function. On the other hand, if the antioxidant treatment takes place after the summit of the bell-shaped dose response curve, antioxidant treatment would have beneficial effects on function. We suggest that the effects of antioxidant treatment are dependent on the intensity of exercise, since the adaptive response, which is multi pathway dependent, is strongly influenced by exercise intensity. It is further suggested that levels of ROS concentration are associated with peak physiological function and can be extended by physical fitness level and this could be the basis for exercise pre-conditioning. Physical inactivity, aging or pathological disorders increase the sensitivity to oxidative stress by altering the bell-shaped dose response curve.

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Section: Introductionmentioning

confidence: 73%

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

et al. 2017

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“…Adipose tissues can also express angiogenic factors such as vascular endothelial growth factor, which is an important process in HCC growth. Insulin resistance is involved in cell growth, proliferation, and death [30].…”

Section: Discussionmentioning

confidence: 99%

Statin can reduce the risk of hepatocellular carcinoma among patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis

Zhang

Liu

et al. 2023

European Journal of Gastroenterology &Amp; Hepatology

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Currently, nonalcoholic fatty liver disease (NAFLD) is the main cause of chronic liver disease and liver-related mortality worldwide. Hepatocellular carcinoma (HCC) is a fatal complication in patients with NAFLD. However, whether statins can reduce the risk of HCC in patients with NAFLD remains controversial. We aimed to determine the relationship between statin use and HCC occurrence among patients with NAFLD. We independently retrieved related studies from PubMed, EMBASE, Cochrane Library, Web of Science, and ClinicalTrial.gov (from 1 January 2000 to 27 February 2022). The main outcome was the development of HCC. A fixed-effects model was used to merge odds ratio (OR) in the meta-analysis. Five studies involving 684 363 patients were included. The results of the meta-analysis suggested a significantly lower risk of HCC among statin users with NAFLD [OR = 0.59; 95% confidence interval (CI), 0.39-0.89; I 2 = 87.90%]. Additionally, a lower risk of HCC was observed among patients with NAFLD aged less than 65 years (OR = 0.59; 95% CI, 0.46-0.77; I 2 = 20.50%). Statins can reduce the risk of HCC in patients aged less than 65 years with NAFLD.

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“…Adiponectin and leptin have evolved as crucial signals in many obesity-related pathologies including (NAFLD) [38][39][40]. Adiponectin regulates the metabolism of blood glucose and hepatic fatty acid, and is decreased in NAFLD that might be critically involved in the pro-inflammatory state associated with obesity and related disorders, overproduction of leptin, a rather pro-inflammatory mediator, is considered of equal relevance [41,42]. An imbalanced adipokine profile in obesity consecutively contributes to metabolic inflammation in NAFLD, which is also associated with a substantial risk for developing HCC in the non-cirrhotic stage of disease [43,44].…”

Section: Adipokinesmentioning

confidence: 99%

Novel Mechanism of Nonalcoholic Lipid Accumulation Promoting Malignant Transformation of Hepatocytes

Yao¹,

Zheng²,

Wang³

et al. 2018

Neoplasm

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The incidence of hepatocellular carcinoma (HCC) is steadily increasing in worldwide, which has been a public concern significantly associated with diabetes and non-alcoholic fatty liver disease (NAFLD) is an emerging risk factor with increasing prevalence nowadays, with gradually instead of HBV and HCV, aflatoxin, or alcohol liver disease as major etiological factors. The deeply worrisome aspects of these high risk factors are their large spread in population. Systemic and genetic mechanisms involved in malignant transformation of liver cells as well as useful biomarkers at early stage of HCC are being investigated. However, the exact mechanisms from NAFLD to HCC still remain to be explored. In this paper, some advances of liver lipid accumulation were summarized on the relationship between NAFLD and hepatocytes malignant transformation.

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Linking Nonalcoholic Fatty Liver Disease to Hepatocellular Carcinoma: From Bedside to Bench and Back

Abstract: Traditional therapeutic approaches in NAFLD including metformin and statins may theoretically reduce the risk of HCC by acting on common pathophysiological pathways shared by NAFLD and HCC.

Cited by 11 publications

References 83 publications

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

Statin can reduce the risk of hepatocellular carcinoma among patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis

Novel Mechanism of Nonalcoholic Lipid Accumulation Promoting Malignant Transformation of Hepatocytes

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