2024
DOI: 10.1101/2024.05.17.594711
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Linking single-cell transcriptomes with secretion using secretion-encoded single-cell sequencing (SEC-seq)

Justin Langerman,
Sevana Baghdasarian,
Rene Yu-Hong Cheng
et al.

Abstract: Cells secrete numerous proteins and other biomolecules into their surroundings to achieve critical functions - from communicating with other cells to blocking the activity of pathogens. Secretion of cytokines, growth factors, extracellular vesicles, and even recombinant biologic drugs defines the therapeutic potency of many cell therapies. However, gene expression states that drive specific secretory phenotypes are largely unknown. We provide a protocol that enables linking the Secretion amount of a target pro… Show more

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