Linking sources to early effects by profiling urine metabolome of residents living near oil refineries and coal-fired power plants

Emission-related Heavy Metal Associated with Oxidative Stress in Children: Effect of Antioxidant Intake

“…In previous study conducted in this study area, it found that teenagers and elders who lived in the high exposure areas were with significantly higher levels of urinary oxidative stress markers [6].…”

“…For the petrochemical-related metal exposure, the present study indicated that the study subjects lived in the areas nearby were with significantly higher urinary metal levels except only for Cu with the reverse result (Table 1), and there were limited research revealed the internal metal exposure dose in young children like the present study. In addition, our previous studies investigated the obviously elevated urinary metal levels in all of the residents with different age groups including elders, adults, and teenagers [6,32]. And, we further conducted the distance-to-source analysis and it revealed that the increased concentrations of most urinary heavy metals in study subjects were associated with the decreased distance from the plant, with the only exception of Cu (data not shown).…”

“…For ambient air, the contents of many metals in PM 10 samples were higher during the downwind season in the two townships nearby the complex [31], and the obviously increasing ambient concentrations of vanadium (V) was found in the closer areas of the complex [32]. For internal exposure biomarkers, urinary V and As levels displayed a concentration gradient in accordance with the distance-to-source gradient of V and As exposure [32], and the significant association between proximity to the petrochemical complex and heavy metals and oxidative stress biomarkers was found in teenagers and elders [6,33].…”

“…Industrial exposure to heavy metals has consistently been found to be associated with increased oxidative stress of the populations living in areas of high exposure [3,4,5]. And, epidemiological studies have linked proximity to industries to oxidative stress and related diseases [6,7,8].…”

Nuclear magnetic resonance‐ and mass spectrometry‐based metabolomics to study maleic acid toxicity from repeated dose exposure in rats

“…We recently found the Figure S1 presented in the supplemental materials of our paper (Wu et al, ) may not be the most representative chromatogram generated from the analysis of four oxidative stress biomarkers (8‐NO 2 Gua, 8‐OHdG, HNE‐MA and 8‐isoPGF 2α ) from rat urine samples collected from repeated exposure to maleic acid in this study. The figure was put in the method section intended to demonstrate the feasibility of our analytical platform, which was cited and had been applied in previous research (Chen, Yuan, Shie, Wu, & Chan, ; Wu, Chen, Peng, Cheng, & Wu, ). Upon combing through our experimental raw data, this replacement chromatogram is more appropriate to include in the supplemental materials of this paper.…”