The chapter aims to explore the relationships among transformational, empowering, transactional leadership, entrepreneurial orientation, and knowledge sharing. Additionally, it investigates the role of entrepreneurial orientation as a mediator between these leadership styles and knowledge sharing. The study was conducted using data collected from employees at EgyptAir, with 481 valid responses. The analysis employed partial least squares structural equation modeling (PLS-SEM). The results revealed a positive association between transformational, empowering, and transactional leadership, entrepreneurial orientation, and knowledge sharing. Furthermore, the results indicated that entrepreneurial orientation partially mediates the relationship between transformational, empowering, and transactional leadership and knowledge sharing. The study offers practical recommendations for managers in the tourism and hospitality industry, particularly in the context of airlines, to enhance entrepreneurial orientation and knowledge sharing through different leadership styles.