Linking vitamin B12 and a trembling disorder

Green, Ralph; Christine, Chadwick W.

doi:10.1038/s41422-019-0166-3

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…These measurements in CSF support our prior work showing that lower serum B12 levels predict greater declines in ambulatory capacity in the DATATOP study . Further study of B12 and tHcy should be performed in contemporary PD cohorts and should also explore the relationship of B12 level with markers of LRRK2 kinase activity …”

Section: Discussionsupporting

confidence: 83%

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Relationship of Cerebrospinal Fluid Vitamin B12 Status Markers With Parkinson's Disease Progression

et al. 2020

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Section: Discussionsupporting

confidence: 83%

“…1 Further study of B12 and tHcy should be performed in contemporary PD cohorts and should also explore the relationship of B12 level with markers of LRRK2 kinase activity. 4,26…”

Section: Discussionmentioning

confidence: 99%

Relationship of Cerebrospinal Fluid Vitamin B12 Status Markers With Parkinson's Disease Progression

et al. 2020

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“…Mutations in LRRK2 account for about 5% of hereditary PD [18] and the most common variant (G2019S) has been established to increase LRRK2 activity [19,20]. Since Schaffner and colleagues found that higher levels of B12 inhibit LRRK2 kinase activity, their work suggests that low B12 levels may directly contribute to PD pathogenesis by allowing for increased LRRK2 activity [21].…”

Section: Discussionmentioning

confidence: 99%

Vitamin B12 measurements across neurodegenerative disorders

et al. 2020

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Background: Vitamin B12 deficiency causes a number of neurological features including cognitive and psychiatric disturbances, gait instability, neuropathy, and autonomic dysfunction. Clinical recognition of B12 deficiency in neurodegenerative disorders is more challenging because it causes defects that overlap with expected disease progression. We sought to determine whether B12 levels at the time of diagnosis in patients with Parkinson's disease (PD) differed from those in patients with other neurodegenerative disorders. Methods: We performed a cross-sectional analysis of B12 levels obtained around the time of diagnosis in patients with PD, Multiple System Atrophy (MSA), Dementia with Lewy Bodies (DLB), Alzheimer's disease (AD), Progressive Supranuclear Palsy (PSP), Frontotemporal Dementia (FTD), or Mild Cognitive Impairment (MCI). We also evaluated the rate of B12 decline in PD, AD, and MCI. Results: In multivariable analysis adjusted for age, sex, and B12 supplementation, we found that B12 levels were significantly lower at time of diagnosis in patients with PD than in patients with PSP, FTD, and DLB. In PD, AD, and MCI, the rate of B12 decline ranged from − 17 to − 47 pg/ml/year, much greater than that reported for the elderly population. Conclusions: Further studies are needed to determine whether comorbid B12 deficiency affects progression of these disorders.

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Parkinson's disease and vitamins: a focus on vitamin B12

Rekik,

Santoro,

Poplawska-Domaszewicz

et al. 2024

J Neural Transm

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Parkinson’s disease (PD) has been linked to a vast array of vitamins among which vitamin B12 (Vit B12) is the most relevant and often investigated specially in the context of intrajejunal levodopa infusion therapy. Vit B12 deficiency, itself, has been reported to cause acute parkinsonism. Nevertheless, concrete mechanisms through which B12 deficiency interacts with PD in terms of pathophysiology, clinical manifestation and progression remains unclear. Recent studies have suggested that Vit B12 deficiency along with the induced hyperhomocysteinemia are correlated with specific PD phenotypes characterized with early postural instability and falls and more rapid motor progression, cognitive impairment, visual hallucinations and autonomic dysfunction. Specific clinical features such as polyneuropathy have also been linked to Vit B12 deficiency specifically in context of intrajejunal levodopa therapy. In this review, we explore the link between Vit B12 and PD in terms of physiopathology regarding dysfunctional neural pathways, neuropathological processes as well as reviewing the major clinical traits of Vit B12 deficiency in PD and Levodopa-mediated neuropathy. Finally, we provide an overview of the therapeutic effect of Vit B12 supplementation in PD and posit a practical guideline for Vit B12 testing and supplementation.

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Linking vitamin B12 and a trembling disorder

Cited by 4 publications

References 8 publications

Relationship of Cerebrospinal Fluid Vitamin B12 Status Markers With Parkinson's Disease Progression

Relationship of Cerebrospinal Fluid Vitamin B12 Status Markers With Parkinson's Disease Progression

Vitamin B12 measurements across neurodegenerative disorders

Parkinson's disease and vitamins: a focus on vitamin B12

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