This chapter covers statistical data and initiatives related to the challenges and achievements of road safety in Lithuania. After providing an overview and an evaluation of previous programs to improve road safety in Lithuania, we discuss a selection of various improvements and assessment of safe traffic measures and their efficiency through relevant information from research and statistical data analysis. Priorities to achieve safer behavior of road users, safer streets and roads, safer vehicles, safer rail transport, and higher survival rates after accidents are discussed in more detail. The country-specific issues of pedestrian fatalities in dark hours, intensive land transportation due to geographical location, and accidents related to railway level crossings are also presented.