Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia

Kushairi, Naufal; Phan, Chia Wei; Sabaratnam, Vikineswary; David, Pamela; Naidu, Murali

doi:10.3390/antiox8080261

Cited by 55 publications

(32 citation statements)

References 93 publications

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“…Mushrooms through their powerful antioxidant characteristics have the potential to protect neurons in mitochondrial dysfunctions-associated aging and neurological disorders [204].…”

Section: Mushrooms and Neurological Disordersmentioning

confidence: 99%

Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa

et al. 2021

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The defining characteristics of the traditional Sub-Saharan Africa (SSA) cuisine have been the richness in indigenous foods and ingredients, herbs and spices, fermented foods and beverages, and healthy and whole ingredients used. It is crucial to safeguard the recognized benefits of mainstream traditional foods and ingredients, which gradually eroded in the last decades. Notwithstanding poverty, chronic hunger, malnutrition, and undernourishment in the region, traditional eating habits have been related to positive health outcomes and sustainability. The research prevailed dealing with food availability and access rather than the health, nutrition, and diet quality dimensions of food security based on what people consume per country and on the missing data related to nutrient composition of indigenous foods. As countries become more economically developed, they shift to “modern” occidental foods rich in saturated fats, salt, sugar, fizzy beverages, and sweeteners. As a result, there are increased incidences of previously unreported ailments due to an unbalanced diet. Protein-rich foods in dietary guidelines enhance only those of animal or plant sources, while rich protein sources such as mushrooms have been absent in these charts, even in developed countries. This article considers the valorization of traditional African foodstuffs and ingredients, enhancing the importance of establishing food-based dietary guidelines per country. The crux of this review highlights the potential of mushrooms, namely some underutilized in the SSA, which is the continent’s little exploited gold mine as one of the greatest untapped resources for feeding and providing income for Africa’s growing population, which could play a role in shielding Sub-Saharan Africans against the side effects of an unhealthy stylish diet.

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“…Mushrooms through their powerful antioxidant characteristics have the potential to protect neurons in mitochondrial dysfunctions-associated aging and neurological disorders [204].…”

Section: Mushrooms and Neurological Disordersmentioning

confidence: 99%

Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa

et al. 2021

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“…In detail, common antioxidant properties of these compounds consist of reducing the levels of reactive oxygen and nitrogen species (ROS and RNS, respectively), enhancing superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GSH-Px) and catalase (CAT) activities along with heat shock proteins 70 (HSP70), heme oxygenase-1 (HO-1) and thioredoxin levels, and eventually, decreasing lipid peroxidation assessed as reduction of malondialdehyde (MDA) content and lipoxygenase (LPX) inhibition [6,7,12,17,[26][27][28]69,70,73,75,78,79,81,[85][86][87]. They also counteract mitochondrial alterations, endoplasmic reticulum (ER) stress, and apoptosis by improving mitochondrial membrane potential (MMP) depolarization and ATP production while promoting mitophagy and mitochondrial biogenesis, and by decreasing the levels of C/EBP Homologous Protein (CHOP), pJNK, p-p38, Bax/Bcl-2 ratio, caspases 3, 6 and 9, and cytochrome-c release [12,16,51,68,69,71,73,75,77,78,81,83].…”

Section: Common Neuroprotective Effects Of S Baicalensis H Erinacementioning

confidence: 99%

“…We chose these specific herbs in order to analyse both their overlapping and complementary properties, posing the provocative issue of whether their combined administration may yield synergistic antidepressant-like effects. The general health-promoting effects of S. baicalensis, H. erinaceus and R. rosea in humans and animals are mainly attributable to anti-inflammatory and antioxidant properties [6][7][8][16][17][18][19][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

et al. 2020

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Recent studies focused on the pharmacology and feasibility of herbal compounds as a potential strategy to target a variety of human diseases ranging from metabolic to brain disorders. Accordingly, bioactive ingredients which are found within a variety of herbal compounds are reported to produce both neuroprotective and psychotropic activities which may help to combat mental disorders such as depression, anxiety, sleep disturbances and cognitive alterations. In the present manuscript, we focus on three herbs which appear effective in mitigating anxiety or depression with favourable risk-benefit profiles, namely Scutellaria baicalensis (S. baicalensis), Hericium erinaceus (H. erinaceus) and Rhodiola rosea (R. rosea). These three traditional folk medicinal herbs target the main biochemical events that are implicated in mental disorders, mimicking, to some extent, the mechanisms of action of conventional antidepressants and mood stabilizers with a wide margin of tolerability. In detail, they rescue alterations in neurotransmitter and neuro-endocrine systems, stimulate neurogenesis and the synthesis of neurotrophic factors, and they counteract oxidative stress, mitochondrial dysfunction and inflammation. Albeit the encouraging results that emerge from both experimental and clinical evidence, further studies are needed to confirm and better understand the mental-health promoting, and specifically, the antidepressant effects of these herbs.

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“…15 It is the ability to regrow Myelin the fatty substance around nerve cells this mushroom could be very helpful in treating degenerative nerve conditions in the future. 16 Other The role of lion's mane mushroom mane in diabetes meletus…”

Section: The Role Of Lion Mane Mushroom Mane In Alzheimer's Diseasementioning

confidence: 99%

“…37 Another study conducted in Malaysia in 2019 reported that H. Erinaceous could have a significant neuroprotective effect and anti-inflammatory effect in the neuronglia environment inH2O2-Induced Oxidative stress and LPS-Induced Inflammation in cell model. 38 Older research suggests that extracts of lion's mane mushrooms may encourage nerve cells to grow and repair more quickly. 39 These findings similar to our results that intake of lion's mane for more than 3 months can have neuroprotective effects and assist in the treatment of different neural diseases, feedback satisfaction of H. Erinaceous intake was (18.2%) 7 out of 10.…”

Section: The Role Of Lion's Mane Mushroom In the Nervous Systemmentioning

confidence: 99%

Online Survey for Patient Outcomes on Hericium Erinaceous Mushroom

Younis¹

2020

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Hericium Erinaceous (Lion's Mane) mushroom is steadfast becoming one of the most widespread and familiar of medicinal mushrooms currently available worldwide, this could be due to its many surprising health benefits and it is the ability to treat various ailments. In our study, we connected a questionnaire to the largest internet portal for Hericium Erinaceous (H.Erinaceous) consumers to measure respondents' feedback. The questionnaire addresses the attitude and potential benefits of respondents towards H.Erinaceousintake by using a numeric rating scale (NRS),97respondents took part in our study. The most frequently used of H. Erinaceousin our sample were in the treatment of neural diseases, enhance memory and GI disorders. The benefits and satisfied outcomes were highest with participants who use H. Erinaceous in a dose of 2-3 tablets (3g) twice/day to improve memory and cognitive properties and lowest in the treatment of autism even with high doses. 69.9%of participants did not discuss consuming this mushroom with their physician. Objectives for the study to determine the prevalence and purposes of using the mushroom in different diseases and to predict the outcomes, side effects and the most effective dose taken by participants.

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Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia

Cited by 55 publications

References 93 publications

Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa

Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa

Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

Online Survey for Patient Outcomes on Hericium Erinaceous Mushroom

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