Liothyronine use in a 17 year observational population‐based study ‐ the tears study

Abstract

For patients taking long-term liothyronine we did not identify any additional risk of atrial fibrillation, cardiovascular disease or fractures. There was an increased incident use of antipsychotic medication during follow-up.

Management of Patients Symptomatically Unresponsive to Levothyroxine: Natural Desiccated Thyroid Extract or the Combination of Levothyroxine and Liothyronine? A Research Priority

“…Differences in GHQ caseness and HADS anxiety were not apparent after 12 months. A recent pharmacoepidemiological study did not identify any additional risk of atrial fibrillation, cardiovascular disease or fractures with liothyronine [20].…”

Current evidence for the treatment of hypothyroidism with levothyroxine/levotriiodothyronine combination therapy versus levothyroxine monotherapy

“…67 The only difference that reached statistical significance was an increase in the new use of antipsychotic drugs, an effect that was associated with the use of LT3 (adjusted hazard ratio, 2.26 [95% CI, 1.64-3.11]; P < .01). 67 These data suggest that long-term treatment with LT3 is generally safe although the preponderance of longterm experience in the treatment of hypothyroidism involves LT4…”

“…The results were derived from relatively short‐term trials, with the longest study extending 1 year . A large, long‐term observational study with a maximum 17‐year follow‐up evaluated morbidity and mortality in patients treated with LT3 (n = 400; 327 patients received the LT3 with LT4, and 73 patients received LT3 alone) or LT4 alone (n = 33 955) . No statistically significant between‐treatment differences were observed in the incidences of death, cardiovascular disease, atrial fibrillation, diabetes or fracture outcomes .…”

“…A large, long‐term observational study with a maximum 17‐year follow‐up evaluated morbidity and mortality in patients treated with LT3 (n = 400; 327 patients received the LT3 with LT4, and 73 patients received LT3 alone) or LT4 alone (n = 33 955) . No statistically significant between‐treatment differences were observed in the incidences of death, cardiovascular disease, atrial fibrillation, diabetes or fracture outcomes . The only difference that reached statistical significance was an increase in the new use of antipsychotic drugs, an effect that was associated with the use of LT3 (adjusted hazard ratio, 2.26 [95% CI, 1.64‐3.11]; P < .01) .…”

Combination Levothyroxine and Levotriiodothyronine Therapy for Hypothyroidism Treatment-Is it Worth the Risks?

“…There have been concerns regarding safety of long term LT3 use mainly due to lack of data. Leese et al [20] reported a 17yrs large observation population based study of all patients prescribed thyroid hormone replacement in Tayside Scotland from 1997 to 2014. LT3 was prescribed to 400 patient compared to 33,955 patients who were treated with LT4 monotherapy.…”