Lip cancer and pre-cancerous lesions harbor TP53 mutations, exhibit allelic loss at 9p, 9q, and 17p, but no BRAFV600E mutations

Correa, Gefter Thiago Batista; Bernardes, Vanessa Fátima; Sousa, Sílvia Ferreira de; Diniz, Marina Gonçalves; Salles, José Maria Porcaro; Souza, Renan P.; De-Paula, Alfredo Maurício Batista; Gomez, Ricardo Santiago; Gomes, Carolina Cavaliéri

doi:10.1007/s13277-015-3659-9

Cited by 7 publications

(6 citation statements)

References 41 publications

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“…However, more specific studies to confirm this hypothesis are required. Correa et al (23) found TP53 missense mutations in AC, including CC>TT transitions, a marker of UV damage. The loss of heterozygosity and TP53 mutations detected in AC may therefore be associated with tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of and Factors Associated with Actinic Cheilitis in Extractive Mining Workers

et al. 2018

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The objective of the present study was to determine the prevalence of actinic cheilitis among extractive mining workers and factors associated with the condition, especially the relationship between clinical appearance and the length of occupational exposure to sunlight. A cross-sectional study was performed in Dona Inês, Paraíba, Brazil between 2014 and 2015. A clinical examination, clinical photography and a questionnaire were applied to 201 extractive mining workers. The T-student's, ANOVA one-way, Fisher's exact and Pearson chi-squared tests were performed and the significance level was set at 5%. A high prevalence of actinic cheilitis was observed (38.8%). Length of occupational exposure to sunlight in months (169.63±112.68, p=0.002) was associated with actinic cheilitis. Most workers were Caucasian (p<0.001) and aged 37.41±12.15 years (p=0.004). The time of occupational exposure to sunlight was significant in relation to the following clinical features: atrophy (225.75±97.31; p=0.024); blurred demarcation between the vermilion border of the lip and the skin (186.68±113.15; p=0.032); vertical fissures (210.09±123.07; p=0.046); white and red spotting (199.51±91.80; p=0.004); hard consistency of the lip (225.81±122.34; p=0.012). A high prevalence of actinic cheilitis was found. Age and ethnicity were associated with the presence of AC. Severe clinical presentations of actinic cheilitis were found among participants who had worked for at least 185 months (approximately 15 years) exposed to the sun.

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Section: Discussionmentioning

confidence: 99%

Prevalence of and Factors Associated with Actinic Cheilitis in Extractive Mining Workers

et al. 2018

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“…Tokman and colleagues investigated p16 INK4a and p53 expression in oral SCC. [20] Squamous cell carcinomas of the lip, which they investigated as a sub-group in their study, were found to manifest positive staining with p16 INK4a at a rate of 58%. [26] Similarly, in our study, 63% of cases of SCC of the lip demonstrated positive staining.…”

Section: Resultsmentioning

confidence: 99%

“…[17] Although many studies have inspected the effect of UV light on the skin, very few studies have investigated the mechanisms of AC and SCC development. [18][19][20][21][22] Thus, it is important to understand the mechanism underlying the development of SCC. This study aims to investigate nuclear expressions of p16 INK4a , p14 ARF , and p53 in normal lip mucosa, AC, and SCC of the lip, and therefore, to determine the potential importance of these markers in early carcinogenesis, as well as their relationship with histopathological prognostic factors.…”

Section: Introductionmentioning

confidence: 99%

p16 INK4a , and p14 ARF Expressions in Carcinogenesis of Squamous Cell Carcinoma of the Lip

Akatlı¹,

Ayva²,

Bozdoğan³

2022

Clin Cancer Investig J

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The goal of this study was to clarify the role of p16 INK4a , p14 ARF, and p53 protein expressions in carcinogenesis in squamous cell carcinomas of the lip. The expressions of the p53, p16 INK4a , and p14 ARF proteins were examined in 46 formaline-fixed paraffin embedded tissue specimens, which included 19 cases of squamous cell carcinoma of the lip, 14 cases of actinic cheilitis, and 13 cases of normal mucosa. Immunoreactivity in the peritumoral epithelium adjacent to squamous cell carcinomas was also evaluated. p16 INK4a expression was increased in actinic cheilitis in comparison with normal mucosa (p=0.001). p14 ARF expression progressively increased from normal mucosa to actinic cheilitis (p=0.001) and was observed to decrease significantly during the process of transition from actinic cheilitis to carcinoma (p=0.003). p53 values progressively increased from normal mucosa to actinic cheilitis (p=0.001) and carcinoma (p=0.008). A significant positive correlation was found between p14 ARF and p53 in the peritumoral epithelium adjacent to carcinomas. Our findings indicated that p16 INK4a and p14 ARF immunohistochemistry does not determine whether or not actinic cheilitis has the potential to develop carcinoma. The p14 ARF /p53 pathway is activated in the peritumoral epithelium adjacent to carcinoma; however, this activation would not be adequate to prevent carcinogenesis.

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“…Similar studies conducted by Metgud et al 10 reported an increase in mean serum CRP levels (12.06+1.9 mg/l) in patients suffering from OSCC. [15][16][17][18]…”

Section: Discussionmentioning

confidence: 99%

Correlation of serum biomarker (LDH, CRP, IL-8) levels in pre-malignant and malignant lesions of head and neck

Faiz,

Singh,

Parveen

et al. 2024

PJMS

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A precancerous lesion is often defined as morphologically altered tissue during which the occurrence of carcinoma is more likely than its normal counterpart. Head and neck cancers include cancers of the mouth and therefore the larynx, also as some rarer cancers like cancer of the sinuses, salivary glands, nose, and tympanic cavity. Head and neck cancers are often described as consistent with the sort of cell they begin with. A biomarker could be defined and interpreted as biological molecule which is mostly found in body fluids, blood or even tissues that indicates abnormalities of our body. Here we've taken three biomarkers (LDH, CRP, IL-8) to gauge their level rise in pre-malignant and malignant lesions which are present in our head and neck. Patients attending ENT OPD with primary symptoms indicating premalignant and malignant lesions in the region of head and neck had been included for the analytical study. Complete ENT examination followed by biopsy of the suspicious lesion and blood sample collection was done. A complete of 30 patients were included in each group of premalignant and malignant lesions. No mean serum rise of serum LDH was noted in premalignant and malignant lesions. A mean serum rise of serum CRP was noted in premalignant lesions but was not noted in malignant lesions. However, both premalignant and malignant lesions noted a mean serum rise of IL-8. From a future perspective serum evaluation of biomarkers can become a replacement diagnostic modality for the early evaluation of premalignant lesions and malignant lesions and for monitoring the prognosis of an equivalent.

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Lip cancer and pre-cancerous lesions harbor TP53 mutations, exhibit allelic loss at 9p, 9q, and 17p, but no BRAFV600E mutations

Cited by 7 publications

References 41 publications

Prevalence of and Factors Associated with Actinic Cheilitis in Extractive Mining Workers

Prevalence of and Factors Associated with Actinic Cheilitis in Extractive Mining Workers

p16 INK4a , and p14 ARF Expressions in Carcinogenesis of Squamous Cell Carcinoma of the Lip

Correlation of serum biomarker (LDH, CRP, IL-8) levels in pre-malignant and malignant lesions of head and neck

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