Lipases in Esterification Reactions: A Review

Gamayurova, V. S.; Зиновьева, М. Е.; Шнайдер, К Л; Davletshina, G. A.

doi:10.1134/s2070050421010025

Cited by 19 publications

(6 citation statements)

References 58 publications

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“…A potential route for the enzymatic derivatization of FA resulting in enhancement of antiviral properties is via (trans)esterification. Triaglycerol lipases (EC 3.1.1.3) are most commonly used due to their broad specificity toward lipids and extraordinary robustness in low water media, the latter being required for the formation of esters over hydrolysis (118). There are various reports on the synthesis of FA-based esters employing lipases, including the acylation of FA with ethanol (119), trinolein or trilinolenin (120), glycerol (121,122), arbutin (123), vitamin E (124), phytosterols (125), quercetin (126) and β-sitosterol (127).…”

Section: Potential For Enzymatic Derivatizationmentioning

confidence: 99%

Ferulic Acid From Plant Biomass: A Phytochemical With Promising Antiviral Properties

2022

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Plant biomass is a magnificent renewable resource for phytochemicals that carry bioactive properties. Ferulic acid (FA) is a hydroxycinnamic acid that is found widespread in plant cell walls, mainly esterified to polysaccharides. It is well known of its strong antioxidant activity, together with numerous properties, such as antimicrobial, anti-inflammatory and neuroprotective effects. This review article provides insights into the potential for valorization of FA as a potent antiviral agent. Its pharmacokinetic properties (absorption, metabolism, distribution and excretion) and the proposed mechanisms that are purported to provide antiviral activity are presented. Novel strategies on extraction and derivatization routes, for enhancing even further the antiviral activity of FA and potentially favor its metabolism, distribution and residence time in the human body, are discussed. These routes may lead to novel high-added value biorefinery pathways to utilize plant biomass toward the production of nutraceuticals as functional foods with attractive bioactive properties, such as enhancing immunity toward viral infections.

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Section: Potential For Enzymatic Derivatizationmentioning

confidence: 99%

Ferulic Acid From Plant Biomass: A Phytochemical With Promising Antiviral Properties

2022

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“…The growing need to look for processes at an industrial level that provide higher yields and are more selective, while allowing for a lower expenditure of energy, less organic solvents and reducing the disposal of waste has encouraged the use of enzymes and their immobilized biocatalysts to develop processes under the principles of Green Chemistry [6,7]. Thus, lipases stand out to develop transesterification reactions in which lipid composition could be modified.…”

Section: Introductionmentioning

confidence: 99%

Biocatalysts Based on Immobilized Lipases for the Production of Ethyl Esters of Fatty Acids including Bioactive Gamma-Linolenic Acid from Borage Oil

Berzal,

García-González,

Castejón

et al. 2023

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In the present work, borage oil (Borago officinalis) was used as the main source of gamma linolenic acid (GLA) to obtain ethyl esters by enzymatic ethanolysis using immobilized enzymes for its application in the food industry. Commercial Thermomyces lanuginosus lipase (TLL) was compared to chemical ethanolysis in alkaline medium. In addition, TLL was immobilized by adsorption on hydrophobic porous support (Octadecyl-Sepabeads®) to compare the results. Fatty acid ethyl ester (FAEE) yields of both reactions were compared under the same conditions (25 °C and 200 rpm) and analyzed by GC-MS. Moreover, the conversion yield for borage oil ethanolysis catalyzed by TLL immobilized on C18-Sepabeads® supports was similar to the chemical pathway (93.4% and 99.5%, respectively). When this biocatalyst was used in a solvent-free system (at 40 °C and 200 rpm), it was possible to obtain a high FAEE yield of 84.3% in the first 24 h of reaction. Furthermore, it was possible to re-use the immobilized biocatalyst for the performance of five reaction cycles maintaining 68% of its initial activity. Thus, the use of immobilized enzymes in solvent-free systems is an eco-friendly alternative to obtain GLA ethyl esters for its possible application in cosmetics and food.

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“… 11 Thus, several protection and deprotection steps are necessary to achieve the selective incorporation of a single ester function, consuming a large amount of energy and/or reagents contrary to the principles defined by “Green Chemistry” that requires the development of sustainable technologies with decreased environmentally impact and lesser possibility of side products. 12 …”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, studies on enzymatic immobilization have been widely disseminated by several research group that report better robustness and stability of these biocatalysts, what are suitable for these applications. 12,19,20 …”

Section: Introductionmentioning

confidence: 99%

Lipase-catalyzed acylation of levoglucosan in continuous flow: antibacterial and biosurfactant studies

et al. 2022

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Lipases in Esterification Reactions: A Review

Cited by 19 publications

References 58 publications

Ferulic Acid From Plant Biomass: A Phytochemical With Promising Antiviral Properties

Ferulic Acid From Plant Biomass: A Phytochemical With Promising Antiviral Properties

Biocatalysts Based on Immobilized Lipases for the Production of Ethyl Esters of Fatty Acids including Bioactive Gamma-Linolenic Acid from Borage Oil

Lipase-catalyzed acylation of levoglucosan in continuous flow: antibacterial and biosurfactant studies

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