Lipid abnormalities in end stage renal disease

Oda, Hiroaki

doi:10.1093/ndt/13.suppl_1.45

Cited by 60 publications

(33 citation statements)

References 35 publications

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“…6 Abnormal oxidative stress and impaired antioxidant defense are responsible for characteristic dyslipidemia, consisting of hypertriglyceridemia and low HDL cholesterol levels. 7 This may contribute to the accelerated atherogenesis associated with uremia. 8 In dialysis patients abnormal carnitine metabolism may be associated with clinical problems such as skeletal myopathies, intradialytic symptoms, and reduced cardiac function.…”

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confidence: 99%

Dyslipidemia, Oxidative Stress and Cardiac Dysfunction in Children with Chronic Renal Failure: Effects of L-Carnitine Supplementation

2003

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Background: Secondary carnitine deficiency may develop in chronic renal failure (CRF) patients undergoing longterm hemodialysis (HD), with a resulting higher incidence of cardiovascular diseases, dyslipidemia and oxidative stress. We studied the efficacy of 12 months of L-carnitine supplementation on the amelioration of dyslipidemia, oxidative stress and cardiac dysfunction in 24 CRF children undergoing long-term HD compared with 24 age-and sex-matched controls. Methods: Plasma samples were analyzed spectrophotometerically before and after dialysis sessions and after 2-month supplementation with oral L-carnitine (50 mg/kg/day) for free carnitine (FC), the lipid profile, and oxidative stress markers. Echocardiography the day following dialysis measured cardiac diameters, wall thicknesses, left ventricular mass index (Ml), end diastole and systole volume indices and functions. Results: The pre-dialysis FC concentration was substantially lower than controls and decreased significantly at the end of the dialysis session. Pre-and post-dialysis plasma levels of free fatty acids (FFAs), trigyleride (TG), total cholesterol (TC) and oxidative stress markers significantly increased while high-density lipoprotein cholesterol (HDL-C) and phospholipids significantly decreased compared to controls. Echocardiography detected a significant increase in cardiac diameters and thickness, and systolic and diastolic cardiac dysfunction. After L-carnitine supplementation, plasma levels of FC increased to normal levels. FFAs, TC and HDL-C returned to control levels while TG, phospholipids, and the oxidative stress markers decreased but remained significantly higher than controls. There was a significant decrease in cardiac diameters and an increase in left ventricular diastolic function (E/A ratio), but no correlation between FC levels and echocardiographic parameters. Pre-dialysis, post-dialysis and after treatment, plasma FC level showed a significant positive correlation with HDL-C and phospholipids and a significant negative correlation with each of oxidative stress markers, FFAs, TG and TC. On the other hand, FFAs showed a significant positive correlation with TG, TC, DC, NO and a significant negative correlation with HDL-C and phospholipids. Conclusion: This study demonstrates that CRF children under regular HD suffer from a decrease in the level of plasma FC, dyslipidemia, oxidative stress, and an increase in cardiac diameters and thickness with impairment of cardiac functions. Oral L-carnitine supplementation at a dose of 50 mg/kg for 2 months can increase plasma FC level, improve dyslipidemia, decrease oxidative stress with reduction of cardiac diameters and increase in diastolic function.

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confidence: 99%

Dyslipidemia, Oxidative Stress and Cardiac Dysfunction in Children with Chronic Renal Failure: Effects of L-Carnitine Supplementation

2003

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“…With the progression of kidney injury, patients develop lipid abnormalities, which are characterized by the accumulation of partially metabolized triglyceride-rich particles resulting in the production of predominantly very-low-density lipoprotein and intermediate-density lipoprotein remnants [48]. …”

Section: Management Of CV Risk Factors In Crs Typementioning

confidence: 99%

Cardiorenal Syndrome Type 4: Management

et al. 2013

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Cardiorenal syndrome (CRS) type 4, or chronic renocardiac syndrome, has been defined as ‘chronic abnormalities in renal function leading to cardiac disease' and recognizes the extreme burden of cardiovascular (CV) disease (CVD) risk in patients with chronic kidney disease (CKD). CKD is common and increasingly recognized as a risk factor for CVD. Although during the past 10 years CV morbidity and mortality have decreased markedly in the general population, their rates still remain high among CKD patients. For this reason, CKD patients should be evaluated thoroughly for CV risk factors which require an aggressive management, given the significant implications of CRS type 4 at both individual and societal level. We will review the management of the most important conventional and nonconventional CVD risk factors related to CKD.

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“…Risk of death with CCVD is 20 fold higher in CRF patients compare to general population. [3] CRF induces various metabolic and endocrinal disorders which in turn produce dyslipidaemis along with other omplications. [3,4] Patients of CRF also encountered increased oxidative stress due to decrease antioxidant levels and increased antioxidant level.…”

Section: Introductionmentioning

confidence: 99%

“…[3] CRF induces various metabolic and endocrinal disorders which in turn produce dyslipidaemis along with other omplications. [3,4] Patients of CRF also encountered increased oxidative stress due to decrease antioxidant levels and increased antioxidant level. [5] Name & Address of Corresponding Author Dr. Prem Narayan Vais, Assistant Professor, Department of General Medicine, FH Medical College, Tundla, Uttar Pradesh, India.…”

Section: Introductionmentioning

confidence: 99%

A Study Oxidative Stress and its Correlation with Lipid Profile in Chronic Renal Failure Patients

Goyal¹,

Vais²

2018

AIMDR

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Background: Chronic Renal Failure (CRF) is characterized by gradual, progressive and permanent decrease in the renal functions. Moreover, CRF adversely effects the functioning of the various other organs. Dyslipidemia is the characteristic of the CRF, moreover lipid profile disorder appear from the onset of the CRF. However, severity of disturbance depends on the stage of CRF. MDA one of the important marker of oxidative stress is the product of lipid peroxidation, which is produced by oxidation of poly unsaturated fatty acid. Increased oxidative stress leads to distruction of bio-molecules, protein, DNA and RNA of the cells. Methods: This was a cross sectional type of study conducted in the TMMC & RC, Moradabad (U.P.). Total sixty patients of CRF patients > 20 years were included in the study. Lipid profile which included serum concentration of total cholesterol (TC), triglycerides (TG) and high density lipoprotein (HDL) were calculated enzymatic method CHOD-POD method, GPO-PAP method, CHOD-POD/ Phosphotungstate method respectively Results: There was a significant difference between the mean values of TC (< 0.001), TG (< 0.001), LDL (< 0.001), VLDL (< 0.001) of CRF patients and Control group III. MDA level was significantly high in group I and group II compare to group III. Further, the levels of MDA were significantly high in group I CRF patients on dialysis when compared to group II conservatively managed patients (p < 0.001). Conclusion: Findings of the present study showed that there is increased oxidative stress level as well elevated risk of CVD in CRF patients on dialysis. More of altered level of lipids induces atherosclerosis in CRF patients. Therefore, the present study suggest that management lipids and oxidative stress should be included during the treatment of CRF patients.

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Lipid abnormalities in end stage renal disease

Cited by 60 publications

References 35 publications

Dyslipidemia, Oxidative Stress and Cardiac Dysfunction in Children with Chronic Renal Failure: Effects of L-Carnitine Supplementation

Dyslipidemia, Oxidative Stress and Cardiac Dysfunction in Children with Chronic Renal Failure: Effects of L-Carnitine Supplementation

Cardiorenal Syndrome Type 4: Management

A Study Oxidative Stress and its Correlation with Lipid Profile in Chronic Renal Failure Patients

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