Lipid Accumulation Product and Hypertension Related to Stroke: a 9.2-Year Prospective Study Among Mongolians in China

Zhong, Chongke; Xia, Wei; Zhong, Xiaoyan; Xu, Tian; Li, Hongmei; Zhang, Mingzhi; Wang, Aili; Xu, Tan; Sun, Yingxian; Zhang, Younghong

doi:10.5551/jat.33514

Cited by 27 publications

(23 citation statements)

References 44 publications

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“…It is confirmed by research regarding other ethnic groups [5,25,26]. Some papers report a positive relation between HT occurrence and the value of LAP [11,27]. In our study, hypertensive patients also had a significantly higher LAP compared to people without hypertension.…”

Section: Discussionsupporting

confidence: 88%

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Lipid Accumulation Product (LAP) as an Index of Metabolic and Hormonal Disorders in Aging Men

Rotter

Rył

Szylińska

et al. 2016

Exp Clin Endocrinol Diabetes

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Lipid accumulation product (LAP) is an index used for evaluating lipid overaccumulation in adults. Our study aimed at assessing associations between LAP and metabolic syndrome (MetS) and its components, age-related testosterone deficiency syndrome (TDS), low-density cholesterol (LDL), as well as HOMA-IR (insulin resistance ratio), insulin level in non-diabetics and total testosterone (TT), estradiol E, dehydroepiandrosterone sulphate (DHEAs) and sex hormone-binding globulin (SHBG) in aging men.313 men aged 50-75 were surveyed with regard to the prevalence of diabetes (T2DM) and hypertension (HT). Anthropometric measurements, including waist circumference and arterial pressure, were performed. We also determined the levels of fasting plasma glucose (FPG), total cholesterol (TC), high-density cholesterol (HDL), low-density cholesterol (LDL), triglyceride (TG), insulin, TT, SHBG, DHEAs, and E.Patients with diagnosed MetS, T2DM, HT, obesity, overweight and TDS had a significantly higher LAP compared to those without these conditions. LAP was significantly positively correlated with serum TC, FPG, insulin, DHEAs, as well as APB-systolic concentration, and negatively correlated with HDL, TT, and SHBG.LAP may then be used as a simple and inexpensive biomarker of metabolic disorders, and in risk assessment related to testosterone deficiency in aging men.

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Section: Discussionsupporting

confidence: 88%

“…This confirmed the results obtained on a bigger population by Wakabayashi [28], who studied over 36 000 middle-aged men. Zhong et al [27] suggest that reducing LAP has an anti-hypertensive effect on people with arterial hypertension.…”

Section: Discussionmentioning

confidence: 99%

Lipid Accumulation Product (LAP) as an Index of Metabolic and Hormonal Disorders in Aging Men

Rotter

Rył

Szylińska

et al. 2016

Exp Clin Endocrinol Diabetes

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“…LAP, a new obesity index computed from WC and triglyceride (TG), is a useful indicator of visceral fat,12 as demonstrated by Kahn in 2005 13. Some studies suggest that LAP can also be used to identify metabolic syndromes,14 15 type 2 diabetes mellitus,16 stroke17 and arterial stiffness 18. Additionally, several cross-sectional studies conducted in Japan,19 India14 and Brazil indicate that LAP significantly associated with cardiovascular disease and is a better indicator than BMI for identifying cardiovascular risk 13 20.…”

Section: Introductionmentioning

confidence: 99%

Interaction of lipid accumulation product and family history of hypertension on hypertension risk: a cross-sectional study in the Southern Chinese population

et al. 2019

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ObjectivesThis study aimed at investigating the applicability of a novel index based on waist circumference (WC) and triglyceride (TG) which was named lipid accumulation product (LAP) in the Southern Chinese population, and compared the predictive effects of LAP and other obesity indicators on hypertension risk. Moreover, this study investigated the interactive effects of LAP and family history of hypertension.MethodsA total number of 2079 of community-dwelling adults in Southern China were enrolled in this cross-sectional study. The participants underwent questionnaire surveys, anthropometric tests and laboratory examinations. Themultinomial logistic regression model and receiver operating characteristic curves, including LAP, body mass index (BMI), waist-to-hip ratio (WHR), WC and TG, were used to assess the association between hypertension risk and obesity indexes. The interaction effects were evaluated by relative excess risk of interaction (RERI), attributable proportion due to interaction (AP) and synergy index (SI).ResultsHigher LAP levels have a relatively higher risk of having hypertension in both sexes (males: adjusted OR=2.79 per SD increase, 95% CI 1.43 to 5.44, p<0.001; females: adjusted OR=3.15, 95% CI 1.56 to 6.39, p<0.001). LAP (area under the curve=0.721; 95% CI 0.680 to 0.761) is a better indicator in identifying hypertension risk than BMI, WHR and TG in females, but WC performed better in males. A significant interaction between LAP and family history of hypertension was observed in males (RERI=1.652, 95% CI 0.267 to 3.037; AP=0.516, 95% CI 0.238 to 0.794; SI=3.998, 95% CI 0.897 to 17.820), but there is no statistically significant difference in females.ConclusionsLAP significantly associates with hypertension risk in the Southern Chinese population. It has better performance than BMI, WHR and TG on predicting hypertension risk of the Southern Chinese female population. Moreover, LAP and family history of hypertension might synergistically increase the risk of hypertension.

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“…Lipid accumulation product (LAP), which is calculated as a combination of waist circumference (WC) and fasting plasma triglyceride (TG) levels, has been proposed as an alternative measure of excessive lipid accumulation [ 12 ]. Recently, a growing number of studies have shown that LAP is a powerful marker for diabetes [ 13 ], metabolic syndrome [ 14 , 15 ], and insulin resistance [ 16 ] in the general population and associated with risk of cardiovascular diseases [ 17 – 19 ]. Given the close associations between diabetes, metabolic syndrome, insulin resistance, and hepatic steatosis [ 20 ], these findings inspired us to explore whether LAP could also be a powerful index for identifying NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Lipid accumulation product is a powerful tool to predict non-alcoholic fatty liver disease in Chinese adults

et al. 2017

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BackgroundNon-alcoholic fatty liver disease (NAFLD), recognized as the liver manifestation of metabolic syndrome, is highly prevalent in the general population. Recent studies suggest that lipid accumulation product is significantly associated with metabolic abnormalities. The aim of this study was to assess the accuracy of lipid accumulation product (LAP) as an effective screening tool for diagnosing NAFLD in the general population.MethodsA total of 40,459 subjects aged ≥18 years were enrolled in this cross-sectional study. LAP was calculated as [waist circumference (cm) – 65] × triglyceride concentration (mmol//L) in men and [waist circumference (cm) – 58] × triglyceride concentration (mmol/L) in women. Multiple logistic regression and receiver operating characteristic (ROC) analyses were performed.ResultsAccording to multiple logistic regression analyses, LAP was significantly associated with a higher prevalence and severity of NAFLD in both men and women. When assessed using ROC curve analyses, LAP exhibited high diagnostic accuracy for identifying NAFLD, and the areas under the curves (AUC) in men and women were 0.843 (95% CI 0.837, 0.849) and 0.887 (95% CI 0.882, 0.892), respectively. After further analyzed in different age groups, the diagnostic accuracy of LAP was found to be significantly better in younger age groups (aged 18-34 for men; aged 18-34 and 35-44 years for women) for both sexes.ConclusionsLAP is significantly associated with the presence and severity of NAFLD, and has a high diagnostic accuracy for identifying NAFLD in the general population. The diagnostic accuracy of LAP was especially high among younger age groups.Electronic supplementary materialThe online version of this article (doi:10.1186/s12986-017-0206-2) contains supplementary material, which is available to authorized users.

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Lipid Accumulation Product and Hypertension Related to Stroke: a 9.2-Year Prospective Study Among Mongolians in China

Cited by 27 publications

References 44 publications

Lipid Accumulation Product (LAP) as an Index of Metabolic and Hormonal Disorders in Aging Men

Lipid Accumulation Product (LAP) as an Index of Metabolic and Hormonal Disorders in Aging Men

Interaction of lipid accumulation product and family history of hypertension on hypertension risk: a cross-sectional study in the Southern Chinese population

Lipid accumulation product is a powerful tool to predict non-alcoholic fatty liver disease in Chinese adults

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