Lipid accumulation product and incident cardiovascular events in a normal weight population: Tehran Lipid and Glucose Study

Hosseinpanah, Farhad; Barzin, Maryam; Mirbolouk, Mohammadhassan; Abtahi, Hayedeh; Cheraghi, Leyla; Azizi, Fereidoun

doi:10.1177/2047487314558771

Cited by 55 publications

(41 citation statements)

References 38 publications

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“…Other groups such as Depres [25] reported that WC in combination with fasting triglycerides can be used to identify people with "hypertriglyceridemia-waist phenotype", the results of which are in agreement with other researchers who have demonstrated a strong association between the aforementioned phenotype and the risk of coronary artery disease [26,27].…”

Section: Introductionsupporting

confidence: 86%

Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) a Simple and Clinically Useful Surrogate Marker for Metabolic Syndrome and Cardiovascular Disease Predictor in Non-diabetic Venezuelan Adults

Velasco¹

2017

J.Pharm Pharm Scien

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Objective: To evaluate and compare the relationship between Lipid Accumulation Product (LAP) and Visceral Adiposity index (VAI) with the components of the metabolic syndrome (MetS) in Venezuelan adults. Methods:Cross-sectional, observational analytical study, comprising 332 individuals selected at the Endocrine Service of the Hospital Militar "Dr Carlos Arvelo". Anthropometry (BMI, WC) and fasting biochemical parameters (TG, HDLcholesterol) were measured and the LAP and VAI (fats indexes) were estimated. Patients were classified into 3 groups with and without Metabolic Syndrome following the ATPIII criteria and a group with Cardiovascular Disease (CVD).Results: 73.17% of the individuals were female and 26.82% were male, with 123 (37.04%) individuals without Metabolic Syndrome (non-MetS), 137 (41.27%) with Metabolic Syndrome and 72 (21.68%) with CVD. In the group without Metabolic Syndrome, we found: LAP (6.72 -26.28) and VAI (0.71 -1.85), for the group with Metabolic Syndrome: LAP (42.09 -108.57) and VAI (1.11 -4.15), with significant differences between groups (p <0.005) and in the CVD group and .Discussion: the results obtained agreed with studies carried out in different populations and ethnic groups (Asia, Middle East and Latin America), indicating that the LAP index obtained better precision for MetS screening, regardless of gender and BMI, the VAI index was best predictor of Cardiovascular Disease.

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Section: Introductionsupporting

confidence: 86%

Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) a Simple and Clinically Useful Surrogate Marker for Metabolic Syndrome and Cardiovascular Disease Predictor in Non-diabetic Venezuelan Adults

Velasco¹

2017

J.Pharm Pharm Scien

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“…In addition, it has been reported that although LAP was an independent predictor of cardiovascular events even in normal weight subjects, it had no advantageous capabilities over other anthropometrics indices . Similarly, Dai et al .…”

Section: Discussionmentioning

confidence: 97%

“…Even though a large number of studies in adult population indicate VAI and LAP as reliable markers of cardiometabolic risk advantageous over BMI and WC, there are another ones that report the opposite …”

Section: Introductionmentioning

confidence: 97%

Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?

Kavarić

Klisić

Ninić

2017

Clinical Laboratory Analysis

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“…Chiang et al16 reported that LAP had significantly higher predictability than other obesity indices for prediction of metabolic syndrome among Taiwanese population older than 50 years of age. Additionally, Hosseinpanah et al36 concluded that LAP was an independent predictor of cardiovascular disease among individuals with normal BMI. Conversely, BMI, high C-reactive protein, and insulin resistance were better than LAP for the prediction of prediabetic status and cardiovascular risk in women with polycystic ovary syndrome 37.…”

Section: Discussionmentioning

confidence: 99%

Anthropometric and central obesity indices as predictors of long-term cardiometabolic risk among Saudi young and middle-aged men and women

Abulmeaty

Almajwal

Almadani

et al. 2017

SMJ

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Objectives:To investigate the prediction of long-term cardiometabolic risk using anthropometric and central obesity parameters.Methods:A total of 390 Saudi subjects (men 42.8%) aged 18-50 years were enrolled in a cross-sectional study in King Saud University, Riyadh, Kingdom of Saudi Arabia between August 2014 and January 2016. All participants were instructed to fast for 12 hours before taking blood samples for glucose and lipid panel analyses. A full anthropometric measurement and bioelectric impedance analysis was performed. The anthropometric and central obesity parameters were used for correlation with 30-year Framingham and life-time American College of Cardiology/American Heart Association risk scores. We used receiver operator characteristic curves to select the best predictors with the highest sensitivity and specificity.Results:The best discriminators of the long-term cardiometabolic risk among all the studied variables in men were the visceral adiposity index (VAI) (AUC=0.767), conicity index (CI) (AUC=0.817), and mid-arm muscular area (MAMA) (AUC=0.639). The best predictors for women were body mass index (AUC=0.912), waist circumference (AUC=0.752), and lipid accumulation product (AUC=0.632). The Kappa coefficient and 95% confidence interval ranged from 0.1 to 0.35, which suggests that there is a poor to fair agreement between these indices and cardiovascular risk scores.Conclusion:Long-term cardiometabolic risk can be predicted using simple anthropometric and central obesity indices, and these discriminators were not the same in Saudi men and women.

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Lipid accumulation product and incident cardiovascular events in a normal weight population: Tehran Lipid and Glucose Study

Abstract: LAP is an independent predictor of cardiovascular events in normal BMI subjects, but is not superior over other anthropometrics indices.

Cited by 55 publications

References 38 publications

Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) a Simple and Clinically Useful Surrogate Marker for Metabolic Syndrome and Cardiovascular Disease Predictor in Non-diabetic Venezuelan Adults

Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) a Simple and Clinically Useful Surrogate Marker for Metabolic Syndrome and Cardiovascular Disease Predictor in Non-diabetic Venezuelan Adults

Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?

Anthropometric and central obesity indices as predictors of long-term cardiometabolic risk among Saudi young and middle-aged men and women

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