Lipid and C-Reactive Protein Levels, Cardiovascular Disease Risk Factors and Simvastatin Treatment in Brazilian Individuals

Abstract

Considering that some works have shown CRP as an independent risk factor of CV and that statins could reduce CRP levels and prevent CV events, our findings show that some people that might benefit from the pleiotropic effect of statin remain without treatment if the decision is based only in those classical risk factors present in FRS.

Association of Hydroxylmethyl Glutaryl Coenzyme A Reductase Inhibitors, L-Type Calcium Channel Antagonists, and Biguanides With Rates of Psychiatric Hospitalization and Self-Harm in Individuals With Serious Mental Illness

“…Statins are anti-inflammatory, with effects on levels of interleukin-1β, interleukin-6, tumor necrosis factor, and C-reactive protein. 18 , 19 Extensive evidence suggests that systemic and neuroinflammatory processes are involved in the pathophysiology of psychiatric disorders. 4 Alternatively (or synergistically), HMG-CoA RIs may interact with other substrates for P-glycoprotein (including antipsychotic medications).…”

Interoceptive pathways to understand and treat mental health conditions

“…In a recent demonstration of this in 142 691 patients with bipolar disorder, schizophrenia, or nonaffective psychosis, exposure to hydroxylmethyl glutaryl coenzyme A reductase inhibitors (statins, used to reduce cholesterol and heart disease), L-type calcium channel antagonists (used to reduce blood pressure), and biguanides (used to treat diabetes) were all associated with reduced rates of psychiatric hospitalisation, and in some cases reduced rates of self-harm compared with unexposed periods [93]. These effects may be due to modulation of key physiological systems, for example, statins have anti-inflammatory effects on levels of IL-1β, IL-6, tumour necrosis factor, and CRP [18,19,[93][94][95] in addition to significant effects on the cardiovascular system.…”

Recent Developments in Treating Cognitive Impairment Associated with Schizophrenia

“…Simvastatin is used to treat hyperlipidemia and has additionally demonstrated pleiotropic effects including the decrease of pro-inflammatory cytokines and the amelioration of both cognitive and positive symptoms in patients with schizophrenia [478][479][480][481]. Celecoxib, a cyclo-oxygenase-2-(COX-2)-inhibitor has also been shown to improve cognition in patients with schizophrenia [482].…”