Lipid and hormonal profile of Panamanian women during the menstrual cycle

León, Roquebert; Austin, Kathryn; Richards, Laura Rypstat; Guerrero, François

doi:10.1016/0020-7292(92)90660-b

Cited by 19 publications

(11 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our finding of a decline in total cholesterol and LDL-C over the course of the menstrual cycle is consistent with previous studies by Kim and Kalkhoff, 25 who reported values for both parameters, and Jones et al, 26 Lussier-Cacan et al, 27 Tangney et al, 28 and De Leon et al, 29 who reported only total cholesterol concentrations. Lebech and Kjoer, 30 Woods et al, 31 and Karpanou et al 32 did not, however, observe changes in total and LDL-C during the menstrual cycle in healthy women.…”

Section: Discussionsupporting

confidence: 82%

Increases in Dietary Cholesterol Are Associated With Modest Increases in Both LDL and HDL Cholesterol in Healthy Young Women

Ginsberg

Karmally

Siddiqui

et al. 1995

ATVB

View full text Add to dashboard Cite

We studied the effects of dietary cholesterol intake on lipid and lipoprotein levels in healthy young women (n = 13) who were otherwise eating an American Heart Association (AHA) diet. The study used a randomized, three-way crossover design to determine the effects of 0, 1, or 3 eggs added per day (dietary cholesterol range, 108 to 667 mg/d). Each of the three diets was eaten for 8 weeks, with a washout period between diets. Three fasting blood samples were obtained during the last 3 weeks of each diet period to observe changes in fasting plasma lipid levels associated with the menstrual cycle. We also obtained blood just before and 4 and 8 hours after the subjects ingested a standard high-fat formula. During the menstrual cycle, total cholesterol and LDL cholesterol levels fell by 0.051 mmol/L (1.99 mg/dL) and 0.064 mmol/L (2.48 mg/dL) per week, respectively. HDL cholesterol concentrations increased by 0.060 mmol/L (2.3 mg/dL) per week during the first half of the cycle and then fell by 0.050 mmol/L (1.94 mg/dL) per week during the second half. Therefore, all statistical analyses were performed on values adjusted to midcycle. Total fasting cholesterol concentrations increased by 0.073 mmol/L (2.81 mg/dL) per 100 mg dietary cholesterol added to the diet per day (P=.001). LDL cholesterol increased by 0.054 mmol/ L (2.08 mg/dL) per 100 mg/d dietary cholesterol (P=.003); this accounted for about 75% of the rise in total cholesterol. HDL cholesterol concentrations increased by 0.015 mmol/L (0.57 mg/dL) per 100 mg/d dietary cholesterol (P<.04). There was a wide range of responses among the women. Plasma apoB levels increased significantly, 0.93 mg/dL per 100 mg/d dietary cholesterol (P=. 025), whereas apoA-I levels tended to rise (1.35 mg/dL per 100 mg/d, P=.056). Increases in dietary cholesterol did not produce any observable effects on fasting plasma cholesteryl ester transfer protein levels and had no effect on the response to a standard high-fat formula. Although menstrual-cycle changes in plasma total, LDL, and HDL cholesterol levels were observed, the effects of the diets were similar in the follicular and luteal phases of the menstrual cycle. Additionally, despite changes associated with the menstrual cycle, within-subject variation in plasma total cholesterol was actually smaller in this study than in our study of young men. Keywords plasma lipids; dietary fatty acids; menstrual cycle; lipoproteinsIn a recent study in healthy young men of the effects of increases in dietary cholesterol on plasma lipids and lipoproteins, we demonstrated that plasma total cholesterol levels © 1995 American Heart Association, Inc. Women were not included in our study or in the studies of several others. 2-4 Zanni et al 6 studied the effects of dietary cholesterol in only women, but in that investigation diets were fed for only 15 days. 6 Both men and women have been included in several more recent studies that focused on the effects of dietary cholesterol, 7-9 but only in one 9 were the data analyzed by the sex of the su...

show abstract

Section: Discussionsupporting

confidence: 82%

Increases in Dietary Cholesterol Are Associated With Modest Increases in Both LDL and HDL Cholesterol in Healthy Young Women

Ginsberg

Karmally

Siddiqui

et al. 1995

ATVB

View full text Add to dashboard Cite

show abstract

“…Several studies report no significant differences in plasma TG concentration at various time points during a menstrual cycle (8,32,33), whereas in other studies plasma TG concentration was found to be lower during the luteal phase (LP) than during the follicular phase (FP) (13,42). Some of the discrepancy between findings from different studies may be due to differences in timing within each cycle phase; both plasma estradiol and progesterone concentrations vary markedly within the FP and LP.…”

mentioning

confidence: 97%

No effect of menstrual cycle phase on basal very-low-density lipoprotein triglyceride and apolipoprotein B-100 kinetics

Magkos¹,

Patterson²,

Mittendorfer³

2006

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

(TG), increased total and LDL-cholesterol concentrations and decreased HDL-cholesterol concentration, is an important risk factor for cardiovascular disease. Premenopausal women have a less atherogenic plasma lipid profile and a lower risk of cardiovascular disease than men, but this female advantage disappears after menopause. This suggests that female sex steroids affect lipoprotein metabolism. The impact of variations in the availability of ovarian hormones during the menstrual cycle on lipoprotein metabolism is not known. We therefore investigated whether very-low-density lipoprotein (VLDL)-TG and VLDL-apolipoprotein B-100 (apoB-100) kinetics are different during the follicular (FP) and luteal phases (LP) of the menstrual cycle. We studied seven healthy, premenopausal women (age 27 Ϯ 2 yr, BMI 25 Ϯ 2 kg/m 2 ) once during FP and once during LP. We measured VLDL-TG, VLDL-apoB-100, and plasma free fatty acid (FFA) kinetics by using stable isotope-labeled tracers, VLDL subclass profile by nuclear magnetic resonance spectroscopy, whole body fat oxidation by indirect calorimetry, and the plasma concentrations of lipoprotein lipase (LPL) and hepatic lipase (HL) by ELISA. VLDL-TG and VLDLapoB-100 concentrations in plasma, VLDL-TG and VLDL-apoB-100 secretion rates and mean residence times, VLDL subclass distribution, FFA concentration and rate of appearance in plasma, whole body substrate oxidation, and LPL and HL concentrations in plasma were not different during the FP and the LP. We conclude that VLDL-TG and VLDL-apoB-100 metabolism is not affected by menstrual cycle phase. sex hormones; stable isotope; lipid DYSLIPIDEMIA, characterized by increased plasma triglyceride (TG), increased total and LDL-cholesterol, and reduced HDLcholesterol concentrations, is a major risk factor for cardiovascular disease (41). Premenopausal women have a lesser risk of developing cardiovascular disease than age-matched men, but the "female advantage" disappears after menopause (26). Differences in plasma lipid concentrations, particularly plasma TG concentration, between men and women and pre-and postmenopausal women are likely responsible for this phenomenon. The increase in cardiovascular disease risk resulting from a given rise in plasma TG concentration is more than twofold higher for women than for men (23). Premenopausal women have lower plasma TG concentration than men (55); this difference between the sexes is abolished after menopause because of an increase in plasma TG concentration that coincides with the onset of menopause (10). This suggests a beneficial effect of ovarian hormones on plasma TG metabolism. Findings from studies in postmenopausal women receiving hormone replacement therapy and premenopausal women taking hormonal contraceptives indicate that this is likely due to the lack of progesterone rather than estradiol.Hormone replacement therapy providing progestins alone to postmenopausal women decreases fasting plasma TG concentration, whereas estrogens increase fasting plasma TG concentration (19). Also, estroge...

show abstract

“…Levels of FSH, LH, E2, and P4 are dramatically different at the different phases of the menstrual cycle, which causes greater variation than diurnal variation. 35,36 Prolactin levels are little affected by the menstrual cycle, but are affected by the time of day, relatively high in the evening, relatively low during the day, and close to average in the morning. 37 Serum testosterone level is the highest at around 11:00 AM and the lowest at midnight at around 2:00 AM.…”

Section: Discussionmentioning

confidence: 97%

Health Effects of Electromagnetic Fields on Reproductive-Age Female Operators of Plastic Welding Machines in Fuzhou, China

Zhang

Chen

et al. 2016

Journal of Occupational &Amp; Environmental Medicine

View full text Add to dashboard Cite

show abstract

Lipid and hormonal profile of Panamanian women during the menstrual cycle

Cited by 19 publications

References 9 publications

Increases in Dietary Cholesterol Are Associated With Modest Increases in Both LDL and HDL Cholesterol in Healthy Young Women

Increases in Dietary Cholesterol Are Associated With Modest Increases in Both LDL and HDL Cholesterol in Healthy Young Women

No effect of menstrual cycle phase on basal very-low-density lipoprotein triglyceride and apolipoprotein B-100 kinetics

Health Effects of Electromagnetic Fields on Reproductive-Age Female Operators of Plastic Welding Machines in Fuzhou, China

Contact Info

Product

Resources

About