Lipid-assisted PEG-<i>b</i>-PLA nanoparticles with ultrahigh SN38 loading capability for efficient cancer therapy

Huang, Xiaoyi; Li, Jieyi; Yang, Yanfang; Wang, Zi-Lu; Yang, Xian-Zhu; Lu, Zi-Dong; Xu, Cong-Fei

doi:10.1039/d3bm01469j

Biomater. Sci.

2023

DOI: 10.1039/d3bm01469j

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Lipid-assisted PEG-b-PLA nanoparticles with ultrahigh SN38 loading capability for efficient cancer therapy

Xiaoyi Huang,

Jieyi Li,

Yanfang Yang

et al.

Abstract: Lipid-assisted PEG-b-PLA nanoparticles achieve stable and ultrahigh SN38 entrapment through attenuating intermolecular π–π stacking of SN38 for efficient cancer therapy.

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2024

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Nanomaterial-based cancer immunotherapy: enhancing treatment strategies

Tian,

Liu,

Pei

2024

Front. Chem.

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Cancer immunotherapy has emerged as a pivotal approach for treating various types of cancer, incorporating strategies such as chimeric antigen receptor T-cell (CAR-T) therapy, immune checkpoint blockade therapy, neoantigen peptides, mRNA vaccines, and small molecule modulators. However, the clinical efficacy of these therapies is frequently constrained by significant adverse effects and limited therapeutic outcomes. In recent years, the integration of nanotechnology into cancer immunotherapy has gained considerable attention, showcasing notable advantages in drug delivery, targeted accumulation, controlled release, and localized administration. This review focuses on nanomaterial-based immunotherapeutic strategies, particularly the development and application of nanocarriers such as liposomes, lipid nanoparticles, polymeric nanoparticles, and self-assembling scaffolds. We examine how these strategies can enhance the efficacy of cancer immunotherapy while minimizing adverse effects and analyze their potential for clinical translation.

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Nanomaterial-based cancer immunotherapy: enhancing treatment strategies

Tian,

Liu,

Pei

2024

Front. Chem.

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Lipid-assisted PEG-b-PLA nanoparticles with ultrahigh SN38 loading capability for efficient cancer therapy

Abstract: Lipid-assisted PEG-b-PLA nanoparticles achieve stable and ultrahigh SN38 entrapment through attenuating intermolecular π–π stacking of SN38 for efficient cancer therapy.

Cited by 1 publication

References 47 publications

Nanomaterial-based cancer immunotherapy: enhancing treatment strategies

Nanomaterial-based cancer immunotherapy: enhancing treatment strategies

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