Lipid-based Biomimetics in Drug and Vaccine Delivery

Carmona-Ribeiro, Ana Maria

doi:10.5772/8792

Cited by 4 publications

(5 citation statements)

References 135 publications

(179 reference statements)

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“…In this case, the effective concentrations in the nanostructured assemblies not only protected Gr from the outer medium but also achieved a high organization level, minimizing the microbicidal dose of DODAB required [137]. Self-assembled antimicrobial nanomaterials, in general, and nanoparticles, in particular, with emphasis on biomimetic ones [138][139][140][141][142], will become very important in drug delivery against pathogens; peptide-based drugs, such as antimicrobial peptides, cyclopeptides, and glycopeptides, play important roles in the treatment of drug-resistant bacterial infections due to their unique lower resistance antibacterial mechanism [38,143]. In the next section, recent advances in formulations for AMPs are discussed.…”

Section: Figurementioning

confidence: 99%

Antimicrobial Peptides and Their Assemblies

Carmona-Ribeiro

2023

Future Pharmacology

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Antibiotic resistance requires alternatives to fight multi-drug resistant strains. Antimicrobial peptides (AMPs) act by disrupting or solubilizing microbial cell walls or membranes in accordance with mechanisms difficult to counteract from the microbe’s point of view. In this review, structure–activity relationships for AMPs and their assemblies are discussed, considering not only their self-assembly but also their interactions with their carriers for optimal delivery or their combinations with other complementary antimicrobials or moieties covalently bound to their chemical structure. The effect of the formulations on AMP activity is also evaluated, revealing a myriad of possibilities. Depending on the interaction forces between the AMP, the carrier, or the elements added to the formulations, AMP activity can be reduced, enhanced, or remain unaffected. Approaches protecting AMPs against proteolysis may also reduce their activity.

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Section: Figurementioning

confidence: 99%

Antimicrobial Peptides and Their Assemblies

Carmona-Ribeiro

2023

Future Pharmacology

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“…Particularly important are the cationic lipids or surfactants such as DODAB and cetyltrimethylammonium bromide (CTAB) [63][64][65][66]. Synthetic or natural polymers such as PDDA, PEI, poly(lactide-co-glycolide) acid (PLGA) and chitosan [67][68][69][70][71][72] allow a broad range of sizes for producing cationic NPs in combinations with DODAB; silica and DODAB or polymers and DODAB can also yield a range of controllable nanometric sizes [73,74]. The cationic nature of these NPs enhances their interaction with negatively charged biological molecules and cellular membranes, making them particularly effective for delivering genetic material and antigens into cells.…”

Section: How Particle Size and Positive Charge Drive The Immune Respo...mentioning

confidence: 99%

Emerging Cationic Nanovaccines

Carmona-Ribeiro,

Pérez-Betancourt

2024

Preprint

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Nanovaccines are able to deliver antigen(s) and immunomodulator(s) directly to antigen-presenting cells (APCs) of the lymphatic system. Positive charges improve their uptake by APCs and often drive a Th-1 biased immune response so necessary against infectious diseases caused by intracellular pathogens and cancers. However, cationic compounds often display a dose-dependent toxicity so that systematic evaluation of cytotoxicity against cells in culture is required. After the rapid evolution of nanovaccines against SARS-Covid 2, mRNA vaccines gained much strength and have been designed against several infectious diseases, often relying on cationic components for mRNA protection. Once established the limiting concentration for the cationic compound, cationic nanovaccines perform well eliciting the desired Th-1 improved immune response in most cases. Other valuable approach found in the literature has been the construction of biocompatible nanoparticles (NPs) carrying cationic lipids, polymers or surfactants so that minimization of the concentration for the cationic component led to absence of toxicity. Against cancer, recent constructions of nanovaccines in situ after cancer cell disruption in the presence of adjuvants led to systemic presentation of multiple tumoral antigens yielding, in many instances, prevention of metastasis appearance and conversion of tumors non treatable by immunotherapy into treatable ones.

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“…Other lipid-polymer hybrid nanoparticles consist of a polymer core surrounded by a lipid shell combining properties of both polymeric nanoparticles and liposomes and often referred to as biomimetic nanoparticles [14][15][16][17][18][19][20][21][22][23][55][56][57][58]. Sometimes, when the lipid has good affinity for the polymer, it can be embedded in the polymer matrix as was the case of the cationic lipid dioctadecyl dimethyl ammonium bromide (DODAB) and poly methyl methacrylate (PMMA) polymer for producing microbicidal PMMA/DODAB coatings from spin-coating [59].…”

Section: Lipid Polymer Nanoparticles: Overview On Their Applicationsmentioning

confidence: 99%

“…Cationic lipid polymer NPs and coatings are strategic for applications in antimicrobial biomimetics and vaccine design [7,8,[38][39][40][41][42][43][44][45][55][56][57][58][59]. Due to the cationic lipid, lipid polymer cationic NPs can combine effectively with antibiotics DOI: http://dx.doi.org/10.5772/intechopen.84618 like amphotericin B or miconazole [39,[68][69][70], rifampicin [71], clarithromycin [72], anti-inflammatory hydrophobic drugs like indomethacin [32], nucleic acids [21], oligonucleotides [35,73,74], proteins in general including serum proteins, transmembrane proteins, receptors and toxins [75][76][77][78], antigens [9,20,22,[34][35][36][37], peptides [23,[43][44][45] or polymers [79,80].…”

Section: Cationic Lipid Polymer Nanoparticles Coatings and Applicatimentioning

confidence: 99%

Biomimetic Nanomaterials from the Assembly of Polymers, Lipids, and Surfactants

Carmona-Ribeiro¹

2019

Surfactants and Detergents

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Nanostructured materials require evaluation at a molecular level to become controllable and useful in drug and vaccine delivery. Over the years self-assembled nanomaterials such as nanoparticles and thin films have been prepared, characterized and used for biomedical applications. In this review meaningful examples of biomimetic nanomaterials and their construction based on intermolecular interactions such as the electrostatic attraction or the hydrophobic effect will be discussed. Emphasis will be placed on the interactions between polymers, lipids, surfactants and surfaces leading to bioactive supramolecular assemblies such as nanoparticles and coatings. Among the important applications of the self-assembled nanostructures and films to be reviewed are their antimicrobial effect and their adjuvant activity for vaccine delivery.

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Lipid-based Biomimetics in Drug and Vaccine Delivery

Cited by 4 publications

References 135 publications

Antimicrobial Peptides and Their Assemblies

Antimicrobial Peptides and Their Assemblies

Emerging Cationic Nanovaccines

Biomimetic Nanomaterials from the Assembly of Polymers, Lipids, and Surfactants

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