Lipid-Based Drug Delivery Systems for Cancer Treatment

Arias, José L.; Clares, Beatriz; Morales, María Encarnación; Gallardo, V.; Ruíz, M. A.

doi:10.2174/138945011795906570

Cited by 81 publications

(43 citation statements)

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“…The profit of this kind of drug delivery systems is that the nanoparticle core can be within the nanostructure without being affected by possible external modifications via standard liposomal functionalization techniques (Arias et al, 2011a). Another example of magnetoliposomes includes those synthesized thanks to magnetotactic bacteria, and they are also called magnetosomes, having a typical size of ≈ 35 nm (Lang et al, 2007).…”

Section: Stabilization Methodsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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In this paper we describe the preparation and characterization of magnetic nanocomposites designed for applications in targeted drug delivery. Combining superparamagnetic behavior with proper surface functionalization in a single entity makes it possible to have altogether controlled location and drug loading, and release capabilities. The colloidal vehicles consist of maghemite (γ-Fe2O3) cores surrounded by a gold shell through an intermediate silica coating. The external Au layer confers the particles a high degree of biocompatibility and reactive sites for the transported drug binding. In addition, it permits to take advantage of the strong optical resonance, making it easy to visualize the particles or even control their payload release through temperature changes. The results of the analysis of relaxivity demonstrate that these nanostructures can be used as T 2 contrast agents in magnetic resonance imaging (MRI), but the magnetic cores will be mainly useful in manipulating the particles using external magnetic fields. We describe how optical absorbance and electrokinetic data provide a followup of the progress of the nanostructure formation. Additionally, these techniques, together with confocal microscopy, are employed to demonstrate that the component nanoparticles are capable of loading significant amounts of the antitumor drug doxorubicin, very efficient in the chemotherapy of a wide range of tumors. Colon adenocarcinoma cells were used to test the in vitro release capabilities of the drug-loaded nanocomposites.

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Section: Stabilization Methodsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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“…The hydrophilic and hydrophobic bilayer cores entrap hydrophilic and lipophilic drugs, respectively. Liposomes have been demonstrated to prolong the blood-circulation time of drugs, to alter the pharmacokinetics and distribution of P-gp inhibitors in vivo, and to increase the drug concentration in the tumor cells, while reducing the impact on normal tissues, thus exerting toxicity to enhance the effects of chemotherapy (15)(16)(17)(18)(19)(20)(21). A study by Zhou et al (22), which investigated MDR reversal using doxorubicin (DOX) liposomes in vitro, demonstrated that DOX liposomes were mainly detected in the nucleus of human breast cancer P-gp overexpression cells (MCF-7/Adr) with an increased toxicity, and exhibited a stronger cellular retention capacity in human carcinoma KBv200 cells.…”

Section: Liposomesmentioning

confidence: 99%

Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer

et al. 2016

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Abstract. Multidrug resistance (MDR) to chemotherapy presents a major obstacle in the treatment of cancer patients, which directly affects the clinical success rate of cancer therapy. Current research aims to improve the efficiency of chemotherapy, whilst reducing toxicity to prolong the lives of cancer patients. As with good biocompatibility, high stability and drug release targeting properties, nanodrug delivery systems alter the mechanism by which drugs function to reverse MDR, via passive or active targeting, increasing drug accumulation in the tumor tissue or reducing drug elimination. Given the potential role of nanodrug delivery systems used in multidrug resistance, the present study summarizes the current knowledge on the properties of liposomes, lipid nanoparticles, polymeric micelles and mesoporous silica nanoparticles, together with their underlying mechanisms. The current review aims to provide a reliable basis and useful information for the development of new treatment strategies of multidrug resistance reversal using nanodrug delivery systems. IntroductionAt present, chemotherapy remains the optimal choice for cancer therapy, and tumor multidrug resistance (MDR) is a major factor that reduces the efficacy of chemotherapy (1). MDR is a phenotype that tumor cells acquire, which confers resistance to certain chemotherapy drugs, as well as concurrent cross-resistance to additional antitumor drugs that have different structures or mechanisms of action (2,3). The complexity of MDR has impeded the study of reversal agents (3-5). In recent years, the application of nanotechnology for drug carrier design has resulted in the development of novel nanoparticle drug delivery systems that aim to reverse MDR (6-8). Inorganic nanodrug delivery systems, lipid-based systems and polymer nanodrug delivery systems are the most common nanodrug delivery systems, which exhibit non-toxic, biocompatible and highly stable properties (8,9). The application of nanoparticle drug delivery systems is increasing due to their advantage of controlled and targeted drug release (9,10). Studies have demonstrated that entrapped small molecule drugs (10-200 nm in diameter) are more conducive to drug uptake and efflux; these nanodrug particles function via passive and active mechanisms, whereas in the systemic blood circulation they exhibit sustained release that subsequently enhances intracellular drug accumulation in tumor cells, yielding an improved effect (1,(11)(12)(13)(14). In the present review, the application of nanoparticle drug delivery systems in reversing the MDR of tumors is reviewed, which may provide an improved understanding of novel strategies for cancer therapy. Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer (Review)YINGHONG HUANG 1 , SUSAN P.C. COLE 2 , TIANGE CAI 3 , and YU CAI

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“…The first is usually referred to as "passive targeting", suggesting that the drug-loaded nanocarrier is passively retained in areas with increased microvascular permeability. 7,8 The second is known as "active targeting", which may result in an even greater gradient of drug concentration between the intact and injured tissue due to the specific interaction of the tissue-recognition ligand engrafted on the surface of the carrier and a unique disease marker expressed either on the cell membrane or inside the cell. 9 This interaction results in accumulation of the drug-enriched nanocarrier in the tissue of interest with subsequent release of the drug during biodegradation of the particle coating.…”

Section: Introductionmentioning

confidence: 99%

Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles

Galagudza¹,

Королев²,

Постнов³

et al. 2012

IJN

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Pharmacological agents suggested for infarct size limitation have serious side effects when used at cardioprotective doses which hinders their translation into clinical practice. The solution to the problem might be direct delivery of cardioprotective drugs into ischemic-reperfused myocardium. In this study, we explored the potential of silica nanoparticles for passive delivery of adenosine, a prototype cardioprotective agent, into ischemic-reperfused heart tissue. In addition, the biodegradation of silica nanoparticles was studied both in vitro and in vivo. Immobilization of adenosine on the surface of silica nanoparticles resulted in enhancement of adenosine-mediated infarct size limitation in the rat model. Furthermore, the hypotensive effect of adenosine was attenuated after its adsorption on silica nanoparticles. We conclude that silica nanoparticles are biocompatible materials that might potentially be used as carriers for heart-targeted drug delivery.

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Lipid-Based Drug Delivery Systems for Cancer Treatment

Cited by 81 publications

References 0 publications

Maghemite Functionalization for Antitumor Drug Vehiculization

Maghemite Functionalization for Antitumor Drug Vehiculization

Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer

Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles

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