2022
DOI: 10.34133/2022/9808429
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Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

Abstract: Intelligent drug delivery system based on “stimulus-response” mode emerging a promising perspective in next generation lipid-based nanoparticle. Here, we classify signal sources into physical and physiological stimulation according to their origin. The physical signals include temperature, ultrasound, and electromagnetic wave, while physiological signals involve pH, redox condition, and associated proteins. We first summarize external physical response from three main points about efficiency, particle state, a… Show more

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Cited by 6 publications
(4 citation statements)
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“…These findings emphasize the importance of targeting the TCF7L2-mediated pathway as a potential treatment for the management of metastatic ccRCC. Our research findings support the use of targeted delivery strategies [ 83 ] within the context of the Wnt signaling to inhibit TCF7L2 expression as a potential therapeutic approach for treating ccRCC.…”
Section: Discussionsupporting
confidence: 79%
“…These findings emphasize the importance of targeting the TCF7L2-mediated pathway as a potential treatment for the management of metastatic ccRCC. Our research findings support the use of targeted delivery strategies [ 83 ] within the context of the Wnt signaling to inhibit TCF7L2 expression as a potential therapeutic approach for treating ccRCC.…”
Section: Discussionsupporting
confidence: 79%
“…[97,98] Light-triggered charge conversion can be induced by various wavelengths, including visible light, ultraviolet (UV), and near-infrared (NIR) radiation. [99,100] The different wavelengths can induce NADPH production leading to reduction of sensitive groups like nitrobenzyl alcohols or azo bonds. In one example, protected amine-bridged NPs reversed their surface charge from negative to positive triggered by photolysis under UV irradiation.…”
Section: Exogenous Stimulimentioning
confidence: 99%
“…The intricate interplay between the physicochemical properties and the capability to overcome the tumor tissue barriers of nanomedicines has been reported in our previous studies. 4 The appropriate size, shape and surface charge indeed improve the tissue–cell barrier crossing efficiency of nanomedicines. Nevertheless, the existing interconnected barriers between nanomedicines and their destinations interfere with the final biological behaviors of nanomedicines (Fig.…”
Section: Introductionmentioning
confidence: 99%