Lipid-based microtubes for topical delivery of Amphotericin B

Salerno, Claudia; Chiappetta, Diego Andrés; Arechavala, Alicia; Gorzalczany, Susana; Scioscia, Silvia L.; Bregni, Carlos

doi:10.1016/j.colsurfb.2013.02.001

Cited by 34 publications

(19 citation statements)

References 19 publications

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“…These systems can be highly biocompatible which strongly supports their applicability in customer end products [64]. Some of the systems described in this review are already studied to be used for encapsulation and drug delivery [65,66]. It is clear that a major part of self-assemblies based on fatty acids research for years to come will be focus on the use of fatty acids assemblies as soft responsive particles with specific properties.…”

Section: Summary Conclusion and Outlookmentioning

confidence: 95%

Responsive self-assemblies based on fatty acids

Fameau

Arnould

Saint‐Jalmes

2014

Current Opinion in Colloid & Interface Science

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Section: Summary Conclusion and Outlookmentioning

confidence: 95%

Responsive self-assemblies based on fatty acids

Fameau

Arnould

Saint‐Jalmes

2014

Current Opinion in Colloid & Interface Science

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“…These tubes can be used for drug delivery as illustrated in the literature. 27 Another interest of this system comes from the outstandingly stability over months of the foams produced from these 12-HSA tubes dispersions, which are even described as "ultra-stable". 28 The phase transition of tubes into micelles upon heating leads to fast foam destabilization.…”

Section: Introductionmentioning

confidence: 99%

Morphological Transition in Fatty Acid Self-Assemblies: A Process Driven by the Interplay between the Chain-Melting and Surface-Melting Process of the Hydrogen Bonds

2017

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In surfactant systems, the major role of the nature of the counterion in the surfactant behavior is well-known. However, the effect of the molar ratio between the surfactant and its counterion is less explored in the literature. We investigated the effect of the molar ratio (R) between 12-hydroxystearic acid (12-HSA) and various alkanolamines as a function of the temperature in aqueous solution from the molecular scale to the mesoscale. By coupling microscopy techniques and small-angle neutron scattering, we showed that 12-HSA self-assembled into multilamellar tubes and transitioned into micelles at a precise temperature. This temperature transition depended on both the molar ratio and the alkyl chain length of the counterion and could be precisely tuned from 20 to 75 °C. This thermal behavior was investigated by differential scanning calorimetry and wide-angle X-ray scattering. We highlighted that the transition at the supramolecular scale between tubes and micelles came from two different mechanisms at the molecular scale as a function of the molar ratio. At low R, with an excess of counterion, the transition came from the chain-melting phenomenon. At high R, with an excess of 12-HSA, the transition came from both the chain-melting process and the surface-melting process of the hydrogen bonds. At the mesoscale, this transition of supramolecular assemblies from tubes to micelles delimited a regime of high bulk viscosity, with a regime of low viscosity.

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“…9,37 The test cultures (100 µL) were inoculated into freshly prepared PDA plates (A. niger; 1× 10 5 spores/ml) and YMA plates (C. albicans; OD equivalent to MacFarland standard 0.5) using sterile cotton swabs. 9,37 The test cultures (100 µL) were inoculated into freshly prepared PDA plates (A. niger; 1× 10 5 spores/ml) and YMA plates (C. albicans; OD equivalent to MacFarland standard 0.5) using sterile cotton swabs.…”

Section: Determination Of Antifungal and Anticandidal Activitymentioning

confidence: 99%

“…6 Amphotericin B (AmB), a membrane-active polyene is considered as the most effective gold standard antifungal and is clinically used for the treatment of systemic and local fungal infections. 9 Presently, the preferred route for administration of AmB for above mentioned disease conditions is parenteral. 8 AmB can be administered both intravenously and topically.…”

Section: Introductionmentioning

confidence: 99%

Vitamin E TPGS based nanogel for the skin targeting of high molecular weight anti-fungal drug: development and in vitro and in vivo assessment

2015

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The molecules having molecular weight greater than 500 Da are considered to be ineffective in the treatment of skin diseases due to their low skin permeation. The present study entails the development of Vitamin E TPGS nanoemulsion based nanogel formulation of high molecular weight drug, Amphotericin B (AmB 923 Da), intended for effective treatment of cutaneous fungal infections. The nanoemulsion formulations were prepared in strength similar to the marketed topical formulation and optimized with respect to S mix ratio (surfactant: co-surfactant), type of surfactant, co-surfactant, globule size, size distribution, percent transmittance, dispersibility, viscosity and rheology. The optimized nanoemulsion formulation was further incorporated in gel base to form AmB nanogel formulation. As compared to marketed topical formulation, the optimized nanogel exhibited 3.9 fold higher skin deposition through porcine ear skin. Confocal laser scanning microscopy study (CLSM) showed the specific distribution of AmB in different parts of the skin and confirmed the permeation of nanogel to the deeper layers of the skin. The antifungal activity of optimized nanogel formulation tested using microdilution method was found to be 2.0 fold higher against Aspergillus niger and Candida albicans in contrast to marketed formulation. The results depicted that the prepared nanogel formulation is a better alternative for effective topical delivery of AmB.

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Lipid-based microtubes for topical delivery of Amphotericin B

Cited by 34 publications

References 19 publications

Responsive self-assemblies based on fatty acids

Responsive self-assemblies based on fatty acids

Morphological Transition in Fatty Acid Self-Assemblies: A Process Driven by the Interplay between the Chain-Melting and Surface-Melting Process of the Hydrogen Bonds

Vitamin E TPGS based nanogel for the skin targeting of high molecular weight anti-fungal drug: development and in vitro and in vivo assessment

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