Lipid-based Nanocarriers for Cancer and Tumor Treatment

Abstract

: Cancer and tumor has been major reasons for numerous deaths in this century across the world. Many strategies have been designed to treat, diagnose or prevent cancer. The success of the chemotherapy largely depends on the drug targeting. The advent of nanotechnology has vastly improved the drug delivery for targeting and diagnosis. Nevertheless, the accuracy of drug targeting with polymeric nanoparticles has always been questionable. The polymeric nanoparticles synthesised from varieties of lipid based compounds or combined with vectors such as liposomes, ethosomes, and transferosomes may allow the drug to overcome the issue of resistance to drug absorption in biological membranes. The combined effects of lipid based nanocarriers is known to improve the efficacy and accuracy of polymeric nanoparticles. The present review explores the application of lipid based nano carriers in treatment. A special focus is given to the use of lipid based nanocarriers in the treatment, diagnosis and mitigation of cancer located in blood, brain, lung and colon. The treatment of these cancers has always been questionable as the chances of relapse is very high. The review encompasses the use of lipid based nanocarriers in targeting tissue specific cancer cells.

Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo

“…Another major hurdle in the successful implementation of novel therapeutics for brain tumors is the delivery of these therapeutics across the blood-brain barrier (BBB) and into brain tumor cells. In recent years, nanoparticle-based therapeutic platforms have demonstrated promise in delivering novel drugs directly to the cells within the tumor [5]. This not only makes the drug exert its full impact, but also minimizes toxic side effects to the developing brain.…”

Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system

“… 80 As a biodegradable polymer, GLIADEL wafer can load multiple therapeutic agents for the treatment of malignant glioma in an animal model. 81 The critical property of the biological activity of polymers (such as cyclodextrin, 82 pluronic 85, 83 pluronic 123, 84 and pluronic F127 (ref. 85 )) is that they can bind to RVG peptides and then deliver agents into the CNS to achieve therapeutic purposes.…”

Nanocarriers Used in Drug Delivery to Enhance Immune System in Cancer Therapy

“…The formulation of a liposomal drug improves the biodistribution and pharmacokinetics of a drug. This means that a higher concentration of the drug can be achieved within the tumors, while reducing the concentration of the drug in normal tissue [ 34 , 35 ]. Lipid-based nanocarriers include liposomes, nanoemulsions, solid lipid nanoparticles, and phospholipid micelles.…”