Lipid-based nanosuspensions for oral delivery of peptides, a critical review

Dumont, Camille; Bourgeois, Sandrine; Fessi, Hatem; Jannin, Vincent

doi:10.1016/j.ijpharm.2018.02.038

Cited by 87 publications

(49 citation statements)

References 139 publications

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“…Peptelligence®, Robotic pill®, Nanocells® are other technology platforms currently in use by pharmaceutical industries to boost oral delivery of peptides [ 77 ]. Similarly, lipid-based nano-suspensions are becoming popular delivery agents for in vitro and in vivo administration and have been studied extensively to develop an improved carrier system for clinical settings [ 78 ].…”

Section: Therapeutic Applications Of Peptidesmentioning

confidence: 99%

Antiviral peptides against Enterovirus A71 causing hand, foot and mouth disease

2021

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Section: Therapeutic Applications Of Peptidesmentioning

confidence: 99%

Antiviral peptides against Enterovirus A71 causing hand, foot and mouth disease

2021

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“…They can entrap hydrophobic as well as hydrophilic proteins. SLN protects the peptides from proteolytic degradation and makes them able to cross the epithelial membrane and increase their bioavailability 61…”

Section: Sln For Proteins and Peptides Deliverymentioning

confidence: 99%

Solid lipid nanoparticles: a promising technology for delivery of poorly water-soluble drugs

Bhatt¹,

Sharma²,

Singh³

et al. 2018

actapharm

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Oral administration of drugs having low water solubility is hampered by various enzymatic barriers present in gastrointestinal (GI) tract. Lipid nanoparticles based on solid matrix have emerged as a potential drug delivery system to improve the absorption and bioavailability of several drugs, especially lipophilic compounds. Solid lipid nanoparticles (SLN) are reported as the most promising technology for oral administration and offered several advantages over conventional dosages formulations including, enhancement in solubility, stability, permeability, and bioavailability with minimal side effects. In this review, we have highlighted recent advances in the development of SLN for the oral, parenteral, rectal, and topical administration of various drugs. We have also summarized the applications of SLN in the treatment of various diseases like tuberculosis, cancer, diabetes, and several nervous system related disorders. sustained release, timed release, extended release, and targeted release of a drug. The predominance of nanoparticles over the other drug delivery systems enables them to use for drug targeting. Nanoparticles are 10-100nm in size in which drug is either dispersed or entrapped in a matrix, encapsulated as the solid solution or may be adsorbed on the surface 2 .The nanoparticles are designed to provide intimate contact with GI epithelium, prolong residence time and allow permeation across the cell membrane. A pre-systemic metabolism of a drug can be avoided by using nanoparticles 3 . Lipid nanoparticles are safe to use as they contain lipids, which are included in the category of generally recognized as safe (GRAS). Solid Lipid NanoparticlesSolid lipid nanoparticles are an advanced and rapidly budding field of nanotechnology with several applications in pharmaceutical science. SLN were developed first in 1991. These are the colloidal carriers possesses an average diameter of 10 to 1000nm. They composed of single lipid core matrix dispersed in an aqueous surfactant solution. The carriers like liposomes, polymeric micelles, and porous solids can also be used to enhance the aqueous solubility of a drug. But SLN not only helps to increase the solubility of a drug but also offers target release of drugs. SLN can be used as a carrier for lipophilic as well as hydrophilic drugs 4 . SLN provides stability to the solid lipid matrix and overcomes the disadvantages of liposomes, which includes stability problems 5 . Instead of polymeric nanoparticles, SLN are found to be more compatible with the biological system. Exclusive properties of SLN such as smaller size, larger surface area and interaction of phases at the interface make them valuable candidate 2 . The release of encapsulated compounds is controlled by solid lipid matrix, which also improves the stability of incorporated lipophilic ingredients. The type of lipids, surfactants and their concentration in the formulation of SLN adjust the particle size, drug loading, and release behavior of drugs 5 . The physicochemical characteristics of the solid lipid...

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“…The delivery features of these drug delivery systems could be tailored to achieve either immediate or sustained release properties depending on the appropriate selection of lipid composition. Most of lipids employed in the formulation are generally recognized as safe (GRAS), biocompatible and biodegradable [3]. LBDDs can enhance both transcellular and paracellular transport of drugs by transient disruption of lipid bilayer cells and alteration of tight junction by products of lipid digestion, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, they could permeate challenging physiological barriers such as blood brain barrier without surface modification due to their lipophilic nature [4]. Further, they are promising carriers for protection of therapeutic peptides against harsh GI environment [3]. Ease of preparation, cost effectiveness and possibility of large-scale production make LBDDs more attractive compared to polymeric nanoparticulate delivery systems [5].…”

Section: Introductionmentioning

confidence: 99%

Self-Emulsifying Drug Delivery Systems: Easy to Prepare Multifunctional Vectors for Efficient Oral Delivery

AboulFotouh¹,

Allam²,

El-Badry³

2020

Current and Future Aspects of Nanomedicine

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Self-emulsifying drug delivery systems (SEDDS) have been mainly investigated to enhance the oral bioavailability of drugs belonging to class II of the Biopharmaceutics Classification System. However, in the past few years, they have shown promising outcomes in the oral delivery of various types of therapeutic agents. In this chapter, we discuss the recent progress in the application of SEDDS for oral delivery of protein therapeutics and genetic materials. The role of SEDDS in enhancing the oral bioavailability of P-glycoprotein and cytochrome P450 3A4 substrate drugs is also highlighted. Also, we discuss the most critical evaluation criteria of SEDDS. Additionally, we summarize various solidification techniques employed to transform liquid SEDDS to the more stable solid self-emulsifying drug delivery systems (s-SEDDS) that are associated with high patient compliance. This chapter provides a comprehensive approach to develop high utility SEDDS and their further transformation into s-SEDDS.

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Lipid-based nanosuspensions for oral delivery of peptides, a critical review

Cited by 87 publications

References 139 publications

Antiviral peptides against Enterovirus A71 causing hand, foot and mouth disease

Antiviral peptides against Enterovirus A71 causing hand, foot and mouth disease

Solid lipid nanoparticles: a promising technology for delivery of poorly water-soluble drugs

Self-Emulsifying Drug Delivery Systems: Easy to Prepare Multifunctional Vectors for Efficient Oral Delivery

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